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    Emulsions for Microencapsulation Comprising Biodegradable Surface-Active Block Copolymers as Stabilizers
    1.
    发明申请
    Emulsions for Microencapsulation Comprising Biodegradable Surface-Active Block Copolymers as Stabilizers 审中-公开
    用于包含可生物降解的表面活性嵌段共聚物作为稳定剂的微胶囊化乳液

    公开(公告)号：US20110236496A1

    公开(公告)日：2011-09-29

    申请号：US13071633

    申请日：2011-03-25

    申请人： Peter Markland

    发明人： Peter Markland

    IPC分类号： A61K9/16

    CPC分类号： A61K9/1647 ,  A61K9/1694

    摘要： Disclosed herein are surface-active biodegradable block copolymers comprising one or more hydrophobic blocks and one or more hydrophilic blocks. The surface-active polymers are used as stabilizers in emulsions which are used in microencapsulation processes. Also disclosed are microparticles prepared from the emulsions.

    摘要翻译： 本文公开了包含一个或多个疏水嵌段和一个或多个亲水嵌段的表面活性生物可降解嵌段共聚物。 表面活性聚合物用作微胶囊化方法中使用的乳液中的稳定剂。 还公开了由乳液制备的微粒。

    Reduced-mass, long-acting dosage forms
    3.
    发明申请
    Reduced-mass, long-acting dosage forms 审中-公开
    减质量，长效剂型

    公开(公告)号：US20080305115A1

    公开(公告)日：2008-12-11

    申请号：US12157368

    申请日：2008-06-09

    申请人： Thomas R. Tice ,  Peter Markland ,  Jay K. Staas

    发明人： Thomas R. Tice ,  Peter Markland ,  Jay K. Staas

    IPC分类号： A61K39/395 ,  A61K31/7088

    CPC分类号： C07K16/00 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/7088 ,  A61K2039/505

    摘要： Methods and compositions are disclosed whereby free antibody or nucleic acid co-administered with a long-acting formulation, such as a microparticle or implant, containing the antibody or nucleic acid to achieve a long duration of antibody or nucleic acid release. One result is that less of the long-acting formulation excipient or polymer is needed allowing for small-volume administrations as required, for example, for ocular, intra-dermal, orthopedic, brain and spinal delivery. In one aspect, the free antibody or nucleic acid alone has efficacy for an extended period, during which time, very little or no long-acting formulation antibody or nucleic acid is released. In one aspect, after the free antibody or nucleic acid has diminished activity, is gone, or no longer has activity, the long-acting formulation antibody or nucleic acid begins to release for a desired preprogrammed duration to provide long-acting durations. Less formulation mass is needed because the entire antibody or nucleic acid is not encapsulated or implanted with encapsulation or implant excipient or polymer. In addition, more antibody or nucleic acid can be administered to afford longer-acting formulations.

    摘要翻译： 公开了方法和组合物，其中游离抗体或核酸与包含抗体或核酸的长效制剂如微粒或植入物共同施用以实现长时间的抗体或核酸释放。 一个结果是需要较少的长效制剂赋形剂或聚合物，允许根据需要进行小批量给药，例如用于眼部，皮内，矫形，脑和脊柱递送。 在一个方面，单独的游离抗体或核酸具有长时间的功效，在此期间很少或没有长效的制剂抗体或核酸被释放。 一方面，在游离抗体或核酸活性降低，消失或不再具有活性之后，长效制剂抗体或核酸开始释放所需的预编程持续时间以提供长效持续时间。 需要较少的制剂质量，因为整个抗体或核酸不被包封或植入赋形剂或聚合物包封或植入。 此外，可以施用更多的抗体或核酸以提供长效制剂。

    Injectable delivery of microparticles and compositions therefore
    4.
    发明授权
    Injectable delivery of microparticles and compositions therefore 有权
    因此可以注射微粒和组合物

    公开(公告)号：US09216152B2

    公开(公告)日：2015-12-22

    申请号：US12494174

    申请日：2009-06-29

    申请人： Peter Markland ,  Gary Anthony Winchester ,  Thomas Robert Tice ,  David P. Martin

    发明人： Peter Markland ,  Gary Anthony Winchester ,  Thomas Robert Tice ,  David P. Martin

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/50 ,  A61L27/34 ,  A61L31/10

    CPC分类号： A61K9/1647 ,  A61K9/0019 ,  A61K9/5031 ,  A61K31/485 ,  A61K38/09 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/06 ,  C08L67/04

    摘要： Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and/or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation.

    摘要翻译： 已经开发了制备和使用通过较小或小直径针提供更快流动或改善的注射性的微粒组合物的组合物和方法。 值得注意的是，微粒组合物可以通过比由生物相容或可生物降解的聚合物制备的其它微粒组合物更小直径的针头递送或施用，包括例如聚（丙交酯），聚（丙交酯 - 共 - 乙交酯），聚己内酯或聚 3-羟基丁酸酯。 与其它微粒组合物相比，微粒组合物对于给定的针头尺寸和/或针头的流速可以表现出较高的固体负载。 此外，将微粒组合物的聚合物与其它聚合物配方混合或混合可增强所得制剂的注射性。