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公开(公告)号:US20230167085A1
公开(公告)日:2023-06-01
申请号:US17920943
申请日:2021-05-07
申请人: Wei LAN , John S. Debenham , Amjad Ali , Ying-Duo Gao , Lan Wei , Dexi Yang , Rongze Kuang , Alan Hruza , Peter Nizner , Daniel A. Tatosian , Merck Sharp & Dohme LLC
发明人: Jacqueline D. HICKS , John S. Debenham , Amjad Ali , Ying-Duo Gao , Lan Wei , Dexi Yang , Rongze Kuang , Alan Hruza , Peter Nizner , Daniel A. Tatosian
IPC分类号: C07D401/14 , C07D417/14
CPC分类号: C07D401/14 , C07D417/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.