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公开(公告)号：US20060222845A1
公开(公告)日：2006-10-05
申请号：US10541731
申请日：2004-01-07
CPC分类号： C09D5/14 , A01N25/34 , A01N59/16 , Y10T428/265 , Y10T428/2826 , Y10T428/31721 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , A01N2300/00
摘要： An anti-microbial polymeric film comprising a polymeric substrate layer having a first and second surface and on a surface thereof a coating having a thickness of from about 0.01 to about 14.0 gm and comprising an anti-microbial compound in an amount of from about 0.1 to about 50% by weight of the coating layer, characterised in that (i) said coating provides a heat-seal strength of from 100 g/in to 2500 g/in when heat-sealed to itself and/or (ii) said coating provides a barrier to water vapour and/or oxygen, such that the water vapour transmission rate is in the range of 0.01 to 10 g/100 inches2/day and the oxygen transmission rate is in the range of 0.01 to 10 cm3/100 inches2/day/atm.
摘要翻译： 一种抗微生物聚合物膜，其包含具有第一和第二表面的聚合物基底层，并且在其表面上具有约0.01至约14.0gm的厚度的涂层，并且包含抗微生物化合物的量为约0.1至 涂层的约50重量％，其特征在于（i）所述涂层在热封到其本身时提供100g / in至2500g / in的热密封强度和/或（ii）所述涂层提供 水蒸汽和/或氧气的阻挡，使得水蒸汽透过率在0.01至10g / 100英寸2天的范围内，并且氧气透过率在0.01 至10cm 3/100英寸2天/天/天。
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公开(公告)号：US20060127463A1
公开(公告)日：2006-06-15
申请号：US11013131
申请日：2004-12-15
申请人： Peter Nugara , Bruce Begnoche , Stephen Franzyshen , Fenghua Deng , Daniel Sanders , Christine Creegan , Steven Cosentino
发明人： Peter Nugara , Bruce Begnoche , Stephen Franzyshen , Fenghua Deng , Daniel Sanders , Christine Creegan , Steven Cosentino
CPC分类号： A61K9/703 , A61K9/7084
摘要： A composite structure suitable for making transdermal delivery devices includes in sequence: (a) a liner film layer; (b) a containment layer having from zero to 15 wt % content of vinyl acetate repeating units, the layer including either a thermal bonding copolyester resin or a combination of an ethylene-vinyl acetate component and a nonpolar polymer; and (c) a polyester film layer less than 20 μm in thickness. A drug layer lies either between the liner film layer and the containment layer or within a concave depression in the containment layer. A composition including an ethylene-vinyl acetate component and an ABA block copolymer, wherein the A segments of the block copolymer are styrenic segments, is also provided. The composition includes between 1 and 15 wt % of vinyl acetate repeating units, based on the total weight of composition exclusive of any solvents.
摘要翻译： 适于制备透皮递送装置的复合结构包括：（a）衬垫膜层; （b）包含乙酸乙烯酯重复单元含量为零至15重量％的容纳层，所述层包括热粘合共聚酯树脂或乙烯 - 乙酸乙烯酯组分与非极性聚合物的组合; 和（c）厚度小于20μm的聚酯薄膜层。 药物层位于衬垫膜层和容纳层之间或位于容纳层中的凹陷凹陷内。 还提供了包含乙烯 - 乙酸乙烯酯组分和ABA嵌段共聚物的组合物，其中嵌段共聚物的A链段是苯乙烯链段。 基于不包括任何溶剂的组合物的总重量，该组合物包含1至15重量％的乙酸乙烯酯重复单元。
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