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    Stable injectable .beta.-carotene micellar solutions and their preparation
    1.
    发明授权
    Stable injectable .beta.-carotene micellar solutions and their preparation 失效
    稳定的注射β-胡萝卜素胶束溶液及其制备

    公开(公告)号：US4435427A

    公开(公告)日：1984-03-06

    申请号：US329124

    申请日：1981-12-09

    申请人： Peter P. Hoppe ,  Joachim U. Schneider ,  Bernhard Schulz ,  Hubert Tiefenbacher

    发明人： Peter P. Hoppe ,  Joachim U. Schneider ,  Bernhard Schulz ,  Hubert Tiefenbacher

    IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44 ,  A61K31/015

    CPC分类号： A61K9/0019 ,  A61K9/1075 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44

    摘要： A process for the preparation of .beta.-carotene micellar solutions, wherein a non-ionic emulsifier which is suitable for the preparation of micellar solutions is heated at from 160.degree. to 180.degree. C. and a total of from 20 to 30% by weight, based on the emulsifier, of .beta.-carotene is introduced in the presence of a conventional antioxidant, the hot homogeneous mixture is cooled rapidly to below 100.degree. C. by adding water, and the formulation is brought to the desired concentration of from 3 to 6% by weight by adding further water, and the .beta.-carotene micellar solutions obtained by this process. The non-ionic emulsifiers used in this process have an HLB value of from 12 to 16, and are in particular oxyethylated triglycerides of fatty acids of 12 to 18 carbon atoms containing 20-60 oxyethylene units. Parenteral admininstration of the stable .beta.-carotene micellar solutions according to the invention to cattle relieves the disturbed estrus cycle and impaired fertility caused by .beta.-carotene deficiency.

    摘要翻译： 制备β-胡萝卜素胶束溶液的方法，其中适用于制备胶束溶液的非离子乳化剂在160℃至180℃下加热，总共加入20至30重量％ 基于乳化剂，在常规抗氧化剂存在下引入β-胡萝卜素，将热均匀混合物通过加入水快速冷却至低于100℃，并将制剂达到所需浓度为3至6 通过加入另外的水重量％，以及通过该方法获得的β-胡萝卜素胶束溶液。 在该方法中使用的非离子乳化剂具有12-16的HLB值，特别是含有20-60个氧乙烯单元的12-18个碳原子的脂肪酸的氧乙酸化甘油三酸酯。 根据本发明的稳定的β-胡萝卜素胶束溶液的肠胃外施用可以缓解由β-胡萝卜素缺乏引起的扰乱的发情周期和受损的生育力。

    Preparation of stable injectable .beta.-carotene solubilizates
    2.
    发明授权
    Preparation of stable injectable .beta.-carotene solubilizates 失效
    稳定注射β-胡萝卜素增溶剂的制备

    公开(公告)号：US5453447A

    公开(公告)日：1995-09-26

    申请号：US769025

    申请日：1991-10-01

    申请人： Lutz End ,  Dieter Horn ,  Erik Lueddecke ,  Jachim U. Schneider ,  Peter P. Hoppe ,  Friedrich-Wilhelm Rensmann

    发明人： Lutz End ,  Dieter Horn ,  Erik Lueddecke ,  Jachim U. Schneider ,  Peter P. Hoppe ,  Friedrich-Wilhelm Rensmann

    IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K9/107 ,  A61K31/015 ,  A61K31/07 ,  A61K47/14 ,  A61P15/00 ,  B01F3/08 ,  B01F17/00 ,  C07B63/04 ,  C07C403/24 ,  A61K38/00 ,  B01J13/02

    CPC分类号： C07C403/24 ,  A61K31/07 ,  A61K9/0019 ,  A61K9/1075 ,  A61K47/14

    摘要： A process for the continusous preparation of Beta-carotene together with an emulsifier by briefly heating Beta-carotene together with an emulsifier to give a homogeneous solution, rapidly cooling the latter to below 100.degree. C. by adding water, and subsequently adjusting to the required final concentration of Beta-carotene, comprises pumping a suspension, which has been preheated from 20.degree. to 80.degree. C., of 1 to 40% by weight of Beta-carotene in an emulsifier through a heating coil located in a heat transfer oil, where the solubilization mixture is at from 120.degree. to 180.degree. C. and the residence time is from 10 to 300 seconds, and subjecting the homogenous solution to turbulent mixing in a mixing chamber with an amount of water at from 10.degree. to 80.degree. C. to result in a solubilizate which contains from 0.5 to 6% by weight of Beta-carotene and is, if necessary, diluted to the required final concentration.

    摘要翻译： 通过将β-胡萝卜素与乳化剂一起短暂加热以连续制备β-胡萝卜素与乳化剂一起产生均匀的溶液，通过加入水将其快速冷却至低于100℃，随后调节至所需的 β-胡萝卜素的最终浓度包括在乳化剂中通过位于传热油中的加热盘管将已经预热至20℃至80℃的悬浮液泵入1至40重量％的β-胡萝卜素， 其中溶解混合物为120-180℃，停留时间为10-300秒，并将均匀溶液在混合室中与10至80℃的水进行湍流混合 导致含有0.5至6重量％的β-胡萝卜素的增溶剂，如果需要，将其稀释至所需的最终浓度。