公开(公告)号：US5453447A

公开(公告)日：1995-09-26

申请号：US769025

申请日：1991-10-01

申请人： Lutz End ,  Dieter Horn ,  Erik Lueddecke ,  Jachim U. Schneider ,  Peter P. Hoppe ,  Friedrich-Wilhelm Rensmann

发明人： Lutz End ,  Dieter Horn ,  Erik Lueddecke ,  Jachim U. Schneider ,  Peter P. Hoppe ,  Friedrich-Wilhelm Rensmann

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K9/107 ,  A61K31/015 ,  A61K31/07 ,  A61K47/14 ,  A61P15/00 ,  B01F3/08 ,  B01F17/00 ,  C07B63/04 ,  C07C403/24 ,  A61K38/00 ,  B01J13/02

CPC分类号： C07C403/24 ,  A61K31/07 ,  A61K9/0019 ,  A61K9/1075 ,  A61K47/14

摘要： A process for the continusous preparation of Beta-carotene together with an emulsifier by briefly heating Beta-carotene together with an emulsifier to give a homogeneous solution, rapidly cooling the latter to below 100.degree. C. by adding water, and subsequently adjusting to the required final concentration of Beta-carotene, comprises pumping a suspension, which has been preheated from 20.degree. to 80.degree. C., of 1 to 40% by weight of Beta-carotene in an emulsifier through a heating coil located in a heat transfer oil, where the solubilization mixture is at from 120.degree. to 180.degree. C. and the residence time is from 10 to 300 seconds, and subjecting the homogenous solution to turbulent mixing in a mixing chamber with an amount of water at from 10.degree. to 80.degree. C. to result in a solubilizate which contains from 0.5 to 6% by weight of Beta-carotene and is, if necessary, diluted to the required final concentration.

摘要翻译： 通过将β-胡萝卜素与乳化剂一起短暂加热以连续制备β-胡萝卜素与乳化剂一起产生均匀的溶液，通过加入水将其快速冷却至低于100℃，随后调节至所需的 β-胡萝卜素的最终浓度包括在乳化剂中通过位于传热油中的加热盘管将已经预热至20℃至80℃的悬浮液泵入1至40重量％的β-胡萝卜素， 其中溶解混合物为120-180℃，停留时间为10-300秒，并将均匀溶液在混合室中与10至80℃的水进行湍流混合 导致含有0.5至6重量％的β-胡萝卜素的增溶剂，如果需要，将其稀释至所需的最终浓度。