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    Multitarget Compounds Active at a PPAR and Cannabinoid Receptor
    1.
    发明申请
    Multitarget Compounds Active at a PPAR and Cannabinoid Receptor 审中-公开
    在PPAR和大麻素受体上活跃的多靶化合物

    公开(公告)号：US20110039808A1

    公开(公告)日：2011-02-17

    申请号：US12746008

    申请日：2008-12-22

    申请人： Pierre Desreumaux ,  Salvatore Bellinvia ,  Philippe Chavatte ,  Sergio Baroni

    发明人： Pierre Desreumaux ,  Salvatore Bellinvia ,  Philippe Chavatte ,  Sergio Baroni

    IPC分类号： A61K31/625 ,  C07D215/54 ,  C07D209/12 ,  C07D209/26 ,  A61P29/00

    CPC分类号： C07D215/58 ,  A61K31/00 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4704 ,  A61K31/60 ,  A61K31/606 ,  A61K47/55 ,  C07D209/04

    摘要： There is a need for pharmaceutical compounds which have activity at, at least one of a PPAR and a cannabinoid receptor. Thus there are provided such compounds, wherein the compound comprises: a PPAR pharmacophore and a cannabinoid pharmacophore linked together by a moiety comprising a fused bicyclic ring comprising a five membered ring fused with a six membered ring or a six membered ring fused with a six membered ring; wherein the cannabinoid pharmacophore comprises the fused bicyclic ring; and the PPAR pharmacophore comprises a salicylic acid, alkoxybenzylacetic acid or a alkoxyphenylacetic acid functionality; and wherein the PPAR pharmacophore is linked to the bicyclic ring of the cannabinoid pharmacophore through a linker comprising an amine or an amide functional group.

    摘要翻译： 需要在PPAR和大麻素受体中的至少一种具有活性的药物化合物。 因此，提供了这样的化合物，其中所述化合物包括：PPAR药效团和大麻素药效团，其通过包含稠合双环的部分连接在一起，所述稠合双环包含与六元环稠合的五元环或与六元环稠合的六元环 环; 其中所述大麻素药效团包含稠合双环; 并且PPAR药效团包含水杨酸，烷氧基苄基乙酸或烷氧基苯乙酸官能团; 并且其中所述PPAR药效团通过包含胺或酰胺官能团的接头与大麻素药效团的双环连接。

    Liquid-ink writing instrument having a reservoir fitted with a system to prevent loss of priming
    3.
    发明授权
    Liquid-ink writing instrument having a reservoir fitted with a system to prevent loss of priming 失效
    液体墨水书写工具具有一个装有系统的储存器，以防止起泡的损失

    公开(公告)号：US5865553A

    公开(公告)日：1999-02-02

    申请号：US904698

    申请日：1997-08-01

    申请人： Benoit Flye Sainte Marie ,  Jose Duez ,  Serge Romy ,  Zoltan Trajber ,  Philippe Lefebvre ,  Philippe Chavatte

    发明人： Benoit Flye Sainte Marie ,  Jose Duez ,  Serge Romy ,  Zoltan Trajber ,  Philippe Lefebvre ,  Philippe Chavatte

    IPC分类号： B43K5/12 ,  B43K8/04 ,  B43K5/00

    CPC分类号： B43K8/04 ,  B43K5/12

    摘要： A writing instrument is provided, including a writing tip, a reservoir containing a liquid ink, and a capillary transfer rod extending from a first end to a second end of the reservoir. The capillary transfer rod transfers the liquid ink from the reservoir to the writing tip. A capillary element having an orifice is slidably mounted around the capillary transfer rod so as to move freely in the reservoir. An outside edge of the capillary element comes into the immediate vicinity of an inside wall of the reservoir in such a manner that the capillary element comes substantially flush with an inside wall of the reservoir as it slides along the transfer rod.

    摘要翻译： 提供了一种书写工具，包括书写尖端，包含液体墨水的储存器和从储存器的第一端延伸到第二端的毛细管转移杆。 毛细管转移棒将液体墨水从储存器转移到书写尖端。 具有孔口的毛细管元件可滑动地安装在毛细管转移杆周围，以便在储存器中自由移动。 毛细管元件的外边缘以这样的方式进入储存器的内壁的附近，使得当毛细管元件沿着传送杆滑动时，毛细管元件基本上与储存器的内壁齐平。

    Nib and methods of treating an elongate element designed to form such a nib
    6.
    发明授权
    Nib and methods of treating an elongate element designed to form such a nib 失效
    Nib和处理设计成形成这种笔尖的细长元件的方法

    公开(公告)号：US06893181B1

    公开(公告)日：2005-05-17

    申请号：US10009885

    申请日：2000-05-12

    申请人： José Duez ,  Vincent Bedhome ,  Philippe Chavatte

    发明人： José Duez ,  Vincent Bedhome ,  Philippe Chavatte

    IPC分类号： B29C70/06 ,  B43K1/00 ,  B43K1/12 ,  B43K5/00 ,  B43K8/08 ,  B43M11/06

    CPC分类号： B43K1/12

    摘要： The nib is constituted by a segment of a coherent, elongate element of high porosity material, with at least a first end shaped to form a writing tip. The pores and/or capillaries of said material are blocked over a limited thickness e in particular in the range 0.01 mm to 1 mm, at the longitudinal outer periphery of the elongate element, with the exception of the first end forming a writing tip. In a first variant, blocking is obtained by a sealing agent and performed by continuously impregnating the elongate element with a sealing bath, and setting the agent. In a second variant, the nib is constituted by sintered microbeads and blocking is obtained by localized hot-melting of the microbeads.

    摘要翻译： 笔尖由高孔隙率材料的相干细长元件的段构成，至少第一端成形为形成书写尖端。 除了第一端形成书写尖端之外，所述材料的孔和/或毛细管在有限厚度e，特别是在0.01mm至1mm的范围内在细长元件的纵向外周边被阻挡。 在第一种变型中，通过密封剂获得阻塞，并通过用密封浴连续浸渍细长元件并进行凝固来进行。 在第二种变型中，笔尖由烧结的微珠组成，并且通过微珠的局部热熔化获得阻挡。

    Writing implement using liquid ink, in particular a solvent-based ink
    7.
    发明授权
    Writing implement using liquid ink, in particular a solvent-based ink 失效
    使用液体油墨，特别是溶剂型油墨的书写工具

    公开(公告)号：US5971646A

    公开(公告)日：1999-10-26

    申请号：US986277

    申请日：1997-12-05

    申请人： Philippe Chavatte ,  Jose Duez

    发明人： Philippe Chavatte ,  Jose Duez

    IPC分类号： G01D15/16 ,  B43K8/06 ,  B43K8/04

    CPC分类号： B43K8/06

    摘要： A liquid ink writing implement comprises a body whose rear portion constitutes a reservoir for containing an ink, a transfer rod whose rear end opens out into the reservoir and whose front end projects out from the body and forms a writing tip, and a buffer reservoir in contact with the transfer rod. The ink has a surface tension lying in the range 21 of mN/m to 25 mN/m, and is intended for use on a non-absorbent media made of metal or of plastic. The surface tension of the material constituting the buffer reservoir is less than that of the ink by a predetermined difference which is preferably equal to or less than 4 mN/m, thereby enabling the buffer reservoir to absorb and give back any excess ink coming from the transfer rod by capillarity in the event of variation in the pressure inside the reservoir. The surface tension of the material of the buffer reservoir has been lowered by depositing an agent, whose surface tension is less than that of the ink but within the predetermined difference, e.g. fluorine, polysiloxane, or a fluorine-containing resin.

    摘要翻译： 液体墨水书写工具包括一个主体，其后部构成用于容纳墨水的储存器，一个传送杆，其后端打开到储存器中，其前端从主体伸出并形成一个书写尖端;以及缓冲储存器 与传送杆接触。 油墨的表面张力位于mN / m至25mN / m的范围内，并且用于由金属或塑料制成的非吸收性介质。 构成缓冲容器的材料的表面张力小于油墨的预定差异，优选等于或小于4mN / m，从而使缓冲液储存器能够吸收和回收来自 在储存器内压力变化的情况下，转移杆由毛细管作用。 通过沉积其表面张力小于油墨的试剂，但是在预定的差异范围内，例如缓冲储存器的材料的表面张力已降低。 氟，聚硅氧烷或含氟树脂。

    Process for manufacturing pencil by tri-extrusion and the produced pencil having an intermediate protective casing
    8.
    发明授权
    Process for manufacturing pencil by tri-extrusion and the produced pencil having an intermediate protective casing 失效
    通过三次挤出制造铅笔的方法以及具有中间保护套的生产的铅笔

    公开(公告)号：US5244297A

    公开(公告)日：1993-09-14

    申请号：US25825

    申请日：1993-03-03

    申请人： Jacques Bachelet ,  Philippe Chavatte ,  Guy Chochoy ,  Jose Duez ,  Claude Fouble ,  Didier Lange

    发明人： Jacques Bachelet ,  Philippe Chavatte ,  Guy Chochoy ,  Jose Duez ,  Claude Fouble ,  Didier Lange

    IPC分类号： B29C47/06 ,  B43K19/16

    CPC分类号： B29C47/128 ,  B43K19/16 ,  B29C47/0016

    摘要： According to the invention, the writing or coloring pencil is obtained by tri-extrusion of three thermoplastic materials forming the lead material, the expanded wood material and an intermediate protective layer, containing no expanding agent, which is compatible with the lead material and the wood material and has a melting point which is equal to or higher than the melting points of the lead material and the wood material. The three co-extruded materials all contain in particular the same basic component, such as for example a polystyrene-methacrylate copolymer. The protective layer can be of a different color from the other two layers. The writing or coloring pencil with protective casing between the lead and the expanded wood, all three being in thermoplastic material, is, in particular a pencil with soft or extra-soft lead.

    摘要翻译： 根据本发明，书写或着色铅笔是通过三种热塑性材料的三次挤出而形成的，该三种热塑性材料形成铅材料，膨胀木材和不含膨胀剂的中间保护层，其与铅材料和木材相容 并且具有等于或高于引线材料和木材材料的熔点的熔点。 三种共挤出材料都特别包含相同的基本组分，例如聚苯乙烯 - 甲基丙烯酸酯共聚物。 保护层可以是与其他两层不同的颜色。 在铅和扩展木材之间的保护套的书写或着色铅笔，全部三种是热塑性材料，特别是铅笔，软铅或超软铅笔。