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公开(公告)号：US09090922B2
公开(公告)日：2015-07-28
申请号：US13990220
申请日：2011-11-30
申请人： Sandro Mauro , Daniela Fattori , Piero D'Andrea , Amalia Cipollone , Enzo D'Andrea , Carmela Ercolano
发明人： Sandro Mauro , Daniela Fattori , Piero D'Andrea , Amalia Cipollone , Enzo D'Andrea , Carmela Ercolano
IPC分类号： C12P17/16 , C07D311/58
CPC分类号： C12P17/162 , C07D311/58
摘要： The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
摘要翻译： 本发明涉及一种合成方案1中描述的奈比洛尔产物的新方法，其包括减少数量的高产率步骤，并且特征在于色满酸酯前体的酶拆分。
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2.发明申请Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them 审中-公开羟肟酸盐作为组蛋白脱乙酰酶抑制剂和含有它们的药物制剂公开(公告)号：US20080207694A1
公开(公告)日：2008-08-28
申请号：US11886160
申请日：2006-03-14
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D405/06 , C07B2200/11 , C07D211/34 , C07D211/96 , C07D401/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： Compounds of structure (I) having histone deacetylase (HDAC) inhibitor activity are described. The compounds are chemically characterised by the presence of hydroxamic acid, with zinc as chelator, and an aromatic nucleus connected by a linker in which either a bicyclic aromatic system or a piperidino ring are present.
摘要翻译： 描述了具有组蛋白脱乙酰酶（HDAC）抑制剂活性的结构（I）的化合物。 化合物的化学特征在于存在异羟肟酸，锌作为螯合剂，以及通过其中存在双环芳族体系或哌啶子基环的连接体连接的芳香核。
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