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    Process for coating active principles using a pH-sensitive polymer
    1.
    发明授权
    Process for coating active principles using a pH-sensitive polymer 失效
    使用pH敏感聚合物涂覆活性成分的方法

    公开(公告)号：US5296219A

    公开(公告)日：1994-03-22

    申请号：US17445

    申请日：1993-02-12

    申请人： Pierre Ardaillon ,  Christian Prud'Homme

    发明人： Pierre Ardaillon ,  Christian Prud'Homme

    IPC分类号： A61K9/00 ,  A23K1/00 ,  A23K1/16 ,  A23K1/18 ,  A23K1/20 ,  A23P1/08 ,  A61K9/30 ,  A61K9/32 ,  A61K9/50 ,  A61K9/52 ,  A61K9/58 ,  A61K47/32 ,  A61K9/24

    CPC分类号： A61K9/5026 ,  A23K40/35 ,  A61K9/5089 ,  Y10S514/964

    摘要： A process for coating at least one medicinal and/or foodstuff active principle useful for ruminants. At least one monomer is polymerized in an oil-in-water emulsion in the presence of a surfactant to synthesize a pH-sensitive-polymer composition, the composition being obtained in an oil-in-water emulsion. Without isolation of the pH-sensitive polymer, the oil-in-water emulsion is used to coat the active principle, preferably methionine or lysine or a derivative thereof. The pH-sensitive polymer is not dissolved in an organic solvent(s) in either the polymerization or coating steps. The pH-sensitive polymer is stable at pH 6 but at pH 2, the coated active principle is released.

    摘要翻译： 用于涂覆至少一种可用于反刍动物的药物和/或食品活性成分的方法。 在表面活性剂存在下，将至少一种单体在水包油乳液中聚合以合成pH敏感聚合物组合物，该组合物以水包油乳液获得。 不分离pH敏感聚合物时，水包油乳液用于涂覆活性成分，优选甲硫氨酸或赖氨酸或其衍生物。 在聚合或涂布步骤中，pH敏感聚合物不溶于有机溶剂中。 pH敏感聚合物在pH6下是稳定的，但是在pH2时，涂布的活性成分被释放。

    Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated
    5.
    发明授权
    Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated 失效
    用于涂覆反刍动物和饲料添加剂的饲料添加剂的组合物

    公开(公告)号：US4877621A

    公开(公告)日：1989-10-31

    申请号：US92139

    申请日：1987-09-02

    申请人： Pierre Ardaillon ,  Pierre Autant ,  Paul Bourrain ,  Andre Cartillier

    发明人： Pierre Ardaillon ,  Pierre Autant ,  Paul Bourrain ,  Andre Cartillier

    IPC分类号： A23K1/16 ,  A23K1/00 ,  A23K1/18 ,  A61K9/42 ,  A61K9/50

    CPC分类号： A61K9/5026 ,  A23K40/35 ,  A23K50/10 ,  A61K9/5015

    摘要： A composition for coating a biologically active substance, which is stable in a medium with a pH greater than or equal to 5 and which enables the active substance to be released in a medium with a pH less than or equal to 3.5, consisting of a basic amino copolymer (preferably vinyl-pyridine/styrene copolymer) and a hydrophobic substance with a melting point greater than 60.degree. C. (preferably stearic acid), the hydrophobic substance content being between 50 and 90% of the total mass of the coating, and granules comprising a nucleous containing the biologically active substance, coated with this composition.

    摘要翻译： 一种用于涂覆生物活性物质的组合物，其在pH大于或等于5的介质中是稳定的，并且其能够使活性物质在pH小于或等于3.5的介质中释放，所述介质由碱性 氨基共聚物（优选乙烯基 - 吡啶/苯乙烯共聚物）和熔点大于60℃的疏水物质（优选硬脂酸），疏水物质含量在涂层总质量的50-90％之间，和 包含含有该组合物的生物活性物质的核的颗粒。