公开(公告)号：US08895577B2

公开(公告)日：2014-11-25

申请号：US13867752

申请日：2013-04-22

Applicant: Tom Yao-Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Yefen Zou ,  Pranab Mishra ,  Xiaoyue Zhang ,  Nicholas Valiante

Inventor： Tom Yao-Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Yefen Zou ,  Pranab Mishra ,  Xiaoyue Zhang ,  Nicholas Valiante

IPC: A61K31/44 ,  C07D491/056 ,  C07D495/04 ,  C07D221/12 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D221/12 ,  C07D471/14 ,  C07D491/056 ,  C07D495/04

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.

Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。

公开(公告)号：US20130253002A1

公开(公告)日：2013-09-26

申请号：US13867752

申请日：2013-04-22

Applicant: TOM YAO-HSIANG WU ,  YONGKAI LI ,  ALEX CORTEZ ,  YEFEN ZOU ,  PRANAB MISHRA ,  XIAOYUE ZHANG ,  NICHOLAS VALIANTE

Inventor： TOM YAO-HSIANG WU ,  YONGKAI LI ,  ALEX CORTEZ ,  YEFEN ZOU ,  PRANAB MISHRA ,  XIAOYUE ZHANG ,  NICHOLAS VALIANTE

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D221/12 ,  C07D471/14 ,  C07D491/056 ,  C07D495/04

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.

Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。

公开(公告)号：US08466167B2

公开(公告)日：2013-06-18

申请号：US12921129

申请日：2009-02-27

Applicant: Tom Yao Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Yefen Zou ,  Pranab Mishra ,  Xiaoyue Zhang ,  David Skibinski ,  Manmohan Singh ,  Nicholas Valiante

Inventor： Tom Yao Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Yefen Zou ,  Pranab Mishra ,  Xiaoyue Zhang ,  David Skibinski ,  Manmohan Singh ,  Nicholas Valiante

IPC: A61K31/44 ,  C07D471/00

CPC classification number: C07D471/04 ,  C07D221/12 ,  C07D471/14 ,  C07D491/056 ,  C07D495/04

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.

Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。

公开(公告)号：US06512120B1

公开(公告)日：2003-01-28

申请号：US10095674

申请日：2002-03-12

Applicant: Pranab Mishra ,  Sengen Sun ,  William V. Murray

Inventor： Pranab Mishra ,  Sengen Sun ,  William V. Murray

IPC: C07D47104

CPC classification number: C07D207/26 ,  C07D471/04 ,  C07D491/04

Abstract: This invention is directed to methods of synthesizing densely functionalized pyrrolidine compounds through the use of intramolecular Diels Alder reactions.

Abstract translation: 本发明涉及通过使用分子内狄尔斯阿尔德反应合成密实官能化的吡咯烷化合物的方法。

公开(公告)号：US20110081365A1

公开(公告)日：2011-04-07

申请号：US12921129

申请日：2009-02-27

Applicant: Alex Cortez ,  Yongkai Li ,  Pranab Mishra ,  Manmohan Singh ,  David Skibinski ,  Nicholas Valiante ,  Tom Yao-Hsiang Wu ,  Xiaoyue Zhang ,  Yefen Zou

Inventor： Alex Cortez ,  Yongkai Li ,  Pranab Mishra ,  Manmohan Singh ,  David Skibinski ,  Nicholas Valiante ,  Tom Yao-Hsiang Wu ,  Xiaoyue Zhang ,  Yefen Zou

IPC: A61K39/00 ,  C07D471/04 ,  C07D495/04 ,  C07D413/14 ,  C07D239/70 ,  A61K31/438 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/519 ,  A61P37/02 ,  A61P11/06 ,  A61P37/04

CPC classification number: C07D471/04 ,  C07D221/12 ,  C07D471/14 ,  C07D491/056 ,  C07D495/04

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.

Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。