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公开(公告)号：US20170121421A1
公开(公告)日：2017-05-04
申请号：US15333285
申请日：2016-10-25
申请人： Alex CORTEZ , Bernhard Hubert GEIERSTANGER , Timothy Z. HOFFMAN , Shailaja KASIBHATLA , Tetsuo UNO , Xing WANG , Tom Yao-Hsiang WU
发明人： Alex CORTEZ , Bernhard Hubert GEIERSTANGER , Timothy Z. HOFFMAN , Shailaja KASIBHATLA , Tetsuo UNO , Xing WANG , Tom Yao-Hsiang WU
IPC分类号： C07K16/32 , C07K16/28 , C07H15/26 , A61K47/48 , C07D487/04
摘要： Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.
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2.发明申请COMPOUNDS (CYSTEIN BASED LIPOPEPTIDES) AND COMPOSITIONS AS TLR2 AGONISTS USED FOR TREATING INFECTIONS, INFLAMMATIONS, RESPIRATORY DISEASES ETC. 有权化合物（基于CYSTEIN的脂质体）和组合物作为用于治疗感染，炎症，呼吸系统疾病的TLR2激动剂。公开(公告)号：US20130065861A1
公开(公告)日：2013-03-14
申请号：US13636328
申请日：2011-03-23
申请人： Tom Yao-Hsiang Wu , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan
发明人： Tom Yao-Hsiang Wu , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan
IPC分类号： A61K31/23 , A61P11/06 , A61P11/00 , A61P1/04 , A61P1/00 , A61P35/00 , A61P19/02 , C07F9/40 , A61P31/18 , A61K31/662 , C07D213/56 , A61K31/4402 , C07C237/06 , C07D265/30 , A61K31/5375 , C07D233/61 , A61K31/4164 , C07C237/04
CPC分类号： C07C323/60 , C07C2601/02 , C07D213/56 , C07F9/3808 , C07K5/00
摘要： The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物， 通常，脂肽如Pam3CSK4，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体相关的疾病或病症的方法2.一方面，该化合物可用作增强疫苗有效性的佐剂 。
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公开(公告)号：US20110053893A1
公开(公告)日：2011-03-03
申请号：US12874153
申请日：2010-09-01
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
IPC分类号： A61K31/675 , C07F9/38 , C07F9/42 , A61P31/00 , A61P11/00 , A61P17/00 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US07205328B2
公开(公告)日：2007-04-17
申请号：US10690802
申请日：2003-10-21
申请人： Yun He , Tao Jiang , Kelli L. Kuhen , David Archer Ellis , Baogen Wu , Tom Yao-Hsiang Wu , Badry Bursulaya
发明人： Yun He , Tao Jiang , Kelli L. Kuhen , David Archer Ellis , Baogen Wu , Tom Yao-Hsiang Wu , Badry Bursulaya
IPC分类号： A61K31/405 , C07D209/96
CPC分类号： C07D401/04 , C07D209/34 , C07D209/54 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04
摘要： The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
摘要翻译： 本发明涉及使用羟吲哚和与羟吲哚有关的化合物来抑制病毒，例如HIV。 本发明还涉及用于鉴定和使用试剂的方法，包括抑制细胞中HIV的小分子化学组合物; 以及与艾滋病毒感染和相关疾病状态如艾滋病相关的预防和治疗方法。
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公开(公告)号：US20170044168A1
公开(公告)日：2017-02-16
申请号：US15307510
申请日：2015-04-29
申请人： Alex CORTEZ , Timothy HOFFMAN , Yongkai LI , Tom Yao-Hsiang WU , Xiaoyue ZHANG
发明人： Alex CORTEZ , Timothy HOFFMAN , Yongkai LI , Tom Yao-Hsiang WU , Xiaoyue ZHANG
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.
摘要翻译： 本发明提供了包含这些化合物的化合物，免疫原性组合物和药物组合物以及使用这些化合物治疗与Toll样受体7活性相关的疾病或病症的方法。
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公开(公告)号：US09315530B2
公开(公告)日：2016-04-19
申请号：US13820370
申请日：2011-09-01
申请人： Manmohan Singh , David A. G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
发明人： Manmohan Singh , David A. G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
IPC分类号： A61K39/39 , C07F9/6561 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/095 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/6558 , A61K39/00
CPC分类号： A61K39/39 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/13 , A61K39/145 , A61K39/292 , A61K2039/55505 , A61K2039/55511 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/65583 , C07F9/6561 , C07F9/65616 , Y02A50/466
摘要： Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
摘要翻译： 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。
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公开(公告)号：US08889714B2
公开(公告)日：2014-11-18
申请号：US12990927
申请日：2009-05-04
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号： A61K31/4545 , C07D401/14 , C07D417/14 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04 , C07D417/14
摘要： The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位氧代吡啶上具有式（I）的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US08076359B2
公开(公告)日：2011-12-13
申请号：US12312454
申请日：2007-11-14
申请人： Daniel Dube , Michel Gallant , Erich L. Grimm , Helene Juteau , Sebastien Laliberte , Tom Yao-Hsiang Wu
发明人： Daniel Dube , Michel Gallant , Erich L. Grimm , Helene Juteau , Sebastien Laliberte , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4545 , A61K31/451 , C07D211/60
CPC分类号： C07D211/60 , C07D401/04
摘要： The present invention relates to disubstituted piperidinyl renin inhibitor compounds having the structure (Formula I) and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有结构（式I）的二取代哌啶肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US20110081365A1
公开(公告)日：2011-04-07
申请号：US12921129
申请日：2009-02-27
申请人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
发明人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
IPC分类号： A61K39/00 , C07D471/04 , C07D495/04 , C07D413/14 , C07D239/70 , A61K31/438 , A61K31/4985 , A61K31/5377 , A61K31/519 , A61P37/02 , A61P11/06 , A61P37/04
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US10973826B2
公开(公告)日：2021-04-13
申请号：US15333285
申请日：2016-10-25
申请人： Alex Cortez , Bernhard Hubert Geierstanger , Timothy Z. Hoffman , Shailaja Kasibhatla , Tetsuo Uno , Xing Wang , Tom Yao-Hsiang Wu
发明人： Alex Cortez , Bernhard Hubert Geierstanger , Timothy Z. Hoffman , Shailaja Kasibhatla , Tetsuo Uno , Xing Wang , Tom Yao-Hsiang Wu
摘要： Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.
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