公开(公告)号：US5874111A

公开(公告)日：1999-02-23

申请号：US779904

申请日：1997-01-07

Applicant: Amarnath Maitra ,  Prashant Kumar Ghosh ,  Tapas K. De ,  Sanjeeb Kumar Sahoo

Inventor： Amarnath Maitra ,  Prashant Kumar Ghosh ,  Tapas K. De ,  Sanjeeb Kumar Sahoo

IPC: A61K47/30 ,  A61K9/51 ,  B01J13/04 ,  B01J13/18 ,  C08F2/32 ,  C08F2/44 ,  C08F6/16 ,  C08F26/10 ,  C08L39/06 ,  A61K47/32 ,  B01J13/20

CPC classification number: A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  B01J13/043 ,  B01J13/18

Abstract: Preparation of highly monodispersed polymeric hydrophilic nanoparticles having a size of up to 100 nm (in which may have drug substances encapsulated therein. The process comprises subjecting a mixture of an aqueous solution of a monomer or preformed polymer reverse micelles, a cross linking agent, initiator, and optionally, a drug or target substance to polymerization. The polymerized reaction product is dried for removal of solvent to obtain dried nanoparticles and surfactant employed in the process of preparing reverse micelles. The dry mass is dispersed in aqueous buffer and the surfactant and other toxic material are removed therefrom.

Abstract translation: 制备尺寸高达100nm的高度单分散的聚合物亲水性纳米颗粒（其中可以包封药物物质），该方法包括使单体水溶液或预成型聚合物反胶束，交联剂，引发剂 和任选的药物或目标物质进行聚合，将聚合的反应产物干燥除去溶剂，得到干燥的纳米颗粒和制备反胶束的方法中使用的表面活性剂，将干质量分散在水性缓冲液和表面活性剂等中 从中除去有毒物质。