公开(公告)号：US06979740B2

公开(公告)日：2005-12-27

申请号：US10737589

申请日：2003-12-15

申请人： Rahul Jain ,  Meenakshi Jain ,  Prati Pal Singh ,  Sacita Singh ,  Sandeep Sachdeva ,  Vijai Misra ,  Poduri Ramarao ,  Chaman Lal Kaul ,  Kulbhushan Tikoo

发明人： Rahul Jain ,  Meenakshi Jain ,  Prati Pal Singh ,  Sacita Singh ,  Sandeep Sachdeva ,  Vijai Misra ,  Poduri Ramarao ,  Chaman Lal Kaul ,  Kulbhushan Tikoo

IPC分类号： C07D215/40 ,  C07D215/38 ,  A61K31/47

CPC分类号： C07D215/40

摘要： The present invention is concerned with the development of novel 8-aminoquinoline analogs in the treatment and prevention of malaria and the said compound has broad spectrum of activity against the blood as well as tissue stages of the human malaria parasites makes these compounds very attractive in the cure and prevention of malaria caused by drug-sensitive and multidrug resistant strains and also it is expected that development of these compounds as ideal antimalarial agents may lead to suppression as well as radical cure of the malaria infection with single drug therapy.

摘要翻译： 本发明涉及新型8-氨基喹啉类似物在治疗和预防疟疾方面的发展，并且所述化合物具有广泛的针对血液的活性以及人类疟疾寄生虫的组织阶段，使得这些化合物在 治疗和预防由药物敏感和多药耐药菌株引起的疟疾，并且预期这些化合物作为理想抗疟药物的发展可能导致抑制以及用单一药物治疗疟疾感染的根本治愈。