公开(公告)号：US08338450B2

公开(公告)日：2012-12-25

申请号：US12679443

申请日：2008-09-19

申请人： Sudershan Arora ,  Neelima Sinha ,  Prathap Nair ,  Sai Kumar Chakka ,  Anil Hajare ,  Azmi Reddy ,  Pravin Patil ,  Majid Sayyed ,  Rajender Kumar Kamboj ,  K. H. Sreedhara Swamy ,  Rajan Goel

发明人： Sudershan Arora ,  Neelima Sinha ,  Prathap Nair ,  Sai Kumar Chakka ,  Anil Hajare ,  Azmi Reddy ,  Pravin Patil ,  Majid Sayyed ,  Rajender Kumar Kamboj ,  K. H. Sreedhara Swamy ,  Rajan Goel

IPC分类号： A61K31/44 ,  C07D221/02

CPC分类号： C07D451/02 ,  C07D451/14

摘要： The present invention is related to novel compounds of the general formula A, their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors, which are useful in the treatment or prevention of diseases particularly Type II diabetes, other complications related to diabetes and other pathogenic conditions in which DPP IV enzyme is involved.

摘要翻译： 本发明涉及通式A的新化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，制备上述化合物的方法及其作为二肽基肽酶-IV（DPP- IV）抑制剂，其可用于治疗或预防特别是II型糖尿病的疾病，涉及糖尿病的其它并发症以及涉及DPP IV酶的其它病原性病症。

公开(公告)号：US20100291020A1

公开(公告)日：2010-11-18

申请号：US12679443

申请日：2008-09-19

申请人： Sudershan Arora ,  Neelima Sinha ,  Prathap Nair ,  Sai Kumar Chakka ,  Anil Hajare ,  Azmi Reddy ,  Pravin Patil ,  Majid Sayyed ,  Rajender Kumar Kamboj ,  K.H. Sreedhara Swamy ,  Rajan Goel

发明人： Sudershan Arora ,  Neelima Sinha ,  Prathap Nair ,  Sai Kumar Chakka ,  Anil Hajare ,  Azmi Reddy ,  Pravin Patil ,  Majid Sayyed ,  Rajender Kumar Kamboj ,  K.H. Sreedhara Swamy ,  Rajan Goel

IPC分类号： A61K31/785 ,  A61K31/397 ,  A61K31/439 ,  C07D221/22 ,  A61P3/10 ,  A61P3/08 ,  A61P9/10 ,  A61P3/04 ,  A61P3/06 ,  A61P3/00 ,  A61P9/12 ,  A61P19/10 ,  A61P35/00 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D451/02 ,  C07D451/14

摘要： The present invention is related to novel compounds of the general formula A, their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors, which are useful in the treatment or prevention of diseases particularly Type II diabetes, other complications related to diabetes and other pathogenic conditions in which DPP IV enzyme is involved.

摘要翻译： 本发明涉及通式A的新化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，制备上述化合物的方法及其作为二肽基肽酶-IV（DPP- IV）抑制剂，其可用于治疗或预防特别是II型糖尿病的疾病，涉及糖尿病的其它并发症以及涉及DPP IV酶的其它病原性病症。