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    2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent DPP-IV inhibitors
    2.
    发明授权
    2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent DPP-IV inhibitors 失效
    2-氨基-2- [8-（二甲基氨基甲酰基）-8-氮杂 - 双环[3.2.1]辛-3-基] - 异 - 乙酰基衍生物作为有效的DPP-IV抑制剂

    公开(公告)号：US08748457B2

    公开(公告)日：2014-06-10

    申请号：US13378941

    申请日：2009-09-01

    申请人： Neelima Sinha ,  Prathap Nair ,  Navnath Karche ,  Nabendu Saha ,  Rajan Goel ,  Rajender Kumar Kamboj

    发明人： Neelima Sinha ,  Prathap Nair ,  Navnath Karche ,  Nabendu Saha ,  Rajan Goel ,  Rajender Kumar Kamboj

    IPC分类号： C07D451/02 ,  A61K31/46

    CPC分类号： A61K31/46 ,  C07D451/02

    摘要： The present invention is related to novel 2-Amino-2-[8-(dimethyl carbamoyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-exo-ethanoyl derivatives of the general formula (A), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors, which are useful in the treatment or prevention of diseases particularly Type II diabetes, other complications related to diabetes and other pathogenic conditions in which DPP IV enzyme is involved.

    摘要翻译： 本发明涉及通式（A）的新型2-氨基-2- [8-（二甲基氨基甲酰基）-8-氮杂 - 双环[3.2.1]辛-3-基] - 异 - 乙酰基衍生物， 它们的互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，制备上述化合物的方法，以及它们作为二肽基肽酶-IV（DPP-IV）抑制剂的用途，其可用于治疗或预防疾病 特别是II型糖尿病，与糖尿病有关的其他并发症和涉及DPP IV酶的其他致病条件。

    Novel antimycobacterial compounds
    5.
    发明申请
    Novel antimycobacterial compounds 失效
    新型抗分枝杆菌复合物

    公开(公告)号：US20050192275A1

    公开(公告)日：2005-09-01

    申请号：US11082947

    申请日：2005-03-18

    申请人： Sudershan Arora ,  Vijaykumar Patil ,  Prathap Nair ,  Prasad Dixit ,  Shankar Ajay ,  Rakesh Sinha

    发明人： Sudershan Arora ,  Vijaykumar Patil ,  Prathap Nair ,  Prasad Dixit ,  Shankar Ajay ,  Rakesh Sinha

    IPC分类号： A61P31/00 ,  C07D263/20 ,  C07D413/10 ,  C07D413/14 ,  A61K31/541 ,  A61K31/422 ,  A61K31/496 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02

    CPC分类号： C07D263/20 ,  C07D413/10 ,  C07D413/14

    摘要： Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai. The compound and its pharmaceutically acceptable salts thereof act as antibacterial agents. Also disclosed is a method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial conditions such as Mycobacterium tuberculosis, drug resistant Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai, comprising administering an antimycobacterially effective amount of the said compound and/or pharmaceutically acceptable salts thereof. There is also disclosed a process for the manufacture of the said compound or its pharmaceutically acceptable salts.

    摘要翻译： 属于恶唑烷酮类的新型化合物具有强效的抗分支杆菌特性，特别适用于治疗结核分枝杆菌，鸟分枝杆菌 - 细胞内复合物，偶然遗传和关西等酸性快速生物。 该化合物及其药学上可接受的盐作为抗菌剂。 还公开了一种抑制分枝杆菌细胞生长的方法以及治疗结核分枝杆菌，耐药性结核分枝杆菌，鸟分枝杆菌 - 细胞内复合物，偶发性偶联菌和关西氏菌等分枝杆菌病症的方法，其包括施用抗分枝杆菌有效量 的所述化合物和/或其药学上可接受的盐。 还公开了制备所述化合物或其药学上可接受的盐的方法。