公开(公告)号：US20120034235A1

公开(公告)日：2012-02-09

申请号：US13145773

申请日：2010-01-22

Applicant: Kee Ho Lee ,  Eun Ran Park ,  Pu Hyeon Cha ,  Sang Bum Kim ,  Sun Hoo Park ,  Dong Hyoung Lee ,  Seon Rang Woo ,  Chul Ju Han ,  Yong Ho Ham ,  Eun Ju Lee ,  Myoung Jin Park ,  Sang Gu Hwang ,  Hyun Jin Shin

Inventor： Kee Ho Lee ,  Eun Ran Park ,  Pu Hyeon Cha ,  Sang Bum Kim ,  Sun Hoo Park ,  Dong Hyoung Lee ,  Seon Rang Woo ,  Chul Ju Han ,  Yong Ho Ham ,  Eun Ju Lee ,  Myoung Jin Park ,  Sang Gu Hwang ,  Hyun Jin Shin

IPC: A61K39/395 ,  C12Q1/26 ,  A61P35/00 ,  C40B40/10 ,  C40B30/04 ,  C12Q1/68 ,  G01N33/573

CPC classification number: G01N33/57438 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14

Abstract: A composition for detecting a marker for the diagnosis or prognosis of liver cancer is disclosed. The composition includes an agent capable of assessing the expression level of UQCRH (ubiquinol-cytochrome c reductase hinge protein). In addition, a kit having the composition, a microarray for the diagnosis of liver cancer using the marker, and a method for detecting the marker, and predicting recurrence following surgery in liver cancer patients are disclosed. The marker is able to contribute to the early diagnosis of liver cancer and prediction of recurrence following surgery and survival of liver cancer patients who have undergone hepatic resection, and also is significant for being a promising therapeutic target for liver cancer.

Abstract translation: 公开了一种用于检测肝癌诊断或预后的标志物的组合物。 该组合物包括能够评估UQCRH（ubiquinol-cytochrome c还原酶铰链蛋白）的表达水平的试剂。 此外，公开了具有该组成的试剂盒，使用该标记物诊断肝癌的微阵列，以及用于检测标志物的方法，以及预测肝癌患者手术后的复发。 该标记能够有助于肝癌的早期诊断和手术后的复发预测以及经过肝切除术的肝癌患者的生存，并且对于成为有希望的肝癌治疗靶标也是重要的。

公开(公告)号：US20160038555A1

公开(公告)日：2016-02-11

申请号：US14758053

申请日：2012-03-30

Applicant: Kang Yell Choi ,  Pu Hyeon Cha

Inventor： Kang Yell Choi ,  Pu Hyeon Cha

IPC: A61K36/72 ,  A61K31/235 ,  A23L1/30 ,  A61K31/353

CPC classification number: A61K36/72 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/235 ,  A61K31/353 ,  A23V2200/306 ,  A23V2250/21

Abstract: The invention relates to a composition containing extracts of the fruit of Hoveniadulcis Thunb., gallocatechin, and methyl vanillate as active ingredients for preventing and treating bone disease. The extracts of the fruit of Hoveniadulcis Thunb., the gallocatechin, and the methyl vanillate according to the present invention are natural materials and thus cause no side effects, and may activate the Wnt/β-catenin pathway to promote bone formation rather than inhibiting bone decomposition, and therefore may be effective in treating osteoporosis and related diseases. In addition, the extracts of the fruit of Hoveniadulcis Thunb., the gallocatechin, and the methyl vanillate according to the present invention may have the effects regrowing hair and preventing and treating wounds and metabolic diseases related to the activation of Wnt/β-catenin pathway.

Abstract translation: 本发明涉及含有Hoveniadulcis Thunb。，果前the素和香草酸甲酯作为预防和治疗骨病的活性成分的果实提取物的组合物。 Hoveniadulcis Thunb。，gallocatechin，以及根据本发明的香草酸甲酯的果实的提取物是天然物质，因此不会引起副作用，并且可以激活Wnt / b-cadherin途径以促进骨形成而不是抑制 骨分解，因此可能有效治疗骨质疏松症及相关疾病。 此外，根据本发明的葫芦果甙果实，果酸姜酯和香草酸甲酯的提取物可以具有再生毛发和预防和治疗与Wnt / bgr-catenin的活化相关的伤口和代谢疾病的作用 途径。