公开(公告)号：US06566538B1

公开(公告)日：2003-05-20

申请号：US10185178

申请日：2002-06-27

申请人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

发明人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

IPC分类号： C07D30512

CPC分类号： C07D307/33 ,  C07D307/12 ,  C07D309/06 ,  C07D313/04

摘要： The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

公开(公告)号：US06433197B1

公开(公告)日：2002-08-13

申请号：US09969681

申请日：2001-10-02

申请人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

发明人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

IPC分类号： C07D30702

CPC分类号： C07D307/33 ,  C07D307/12 ,  C07D309/06 ,  C07D313/04

摘要： The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

公开(公告)号：US06306895B1

公开(公告)日：2001-10-23

申请号：US09347113

申请日：1999-07-02

申请人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

发明人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

IPC分类号： A01N4302

CPC分类号： C07D307/33 ,  C07D307/12 ,  C07D309/06 ,  C07D313/04

摘要： The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

摘要翻译： 本发明提供了制备环氧化合物的新方法，包括2,5-二取代的四氢呋喃，2,6-二取代的四氢吡喃，2,7-二取代氧杂环庚烷和2,8-氧代山梨糖醇。 本发明还提供新的环氧化合物和包含这些化合物的药物组合物和治疗方法。

公开(公告)号：US06310221B1

公开(公告)日：2001-10-30

申请号：US09347087

申请日：1999-07-02

申请人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

发明人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

IPC分类号： C07D30512

CPC分类号： C07D307/14 ,  C07D307/12 ,  C07D307/32

摘要： The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.

摘要翻译： 本发明尤其包括制备药学活性化合物2-（4-氟苯氧基甲基）-5-（4-N-羟基脲基-1-丁炔基） - 四氢呋喃及其前体的新方法。

公开(公告)号：US06541647B2

公开(公告)日：2003-04-01

申请号：US09969799

申请日：2001-10-02

申请人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

发明人： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

IPC分类号： C07D30733

CPC分类号： C07D307/14 ,  C07D307/12 ,  C07D307/32

摘要： The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1 -butynyl)-tetrahydrofuran and precursors thereof.

摘要翻译： 本发明尤其包括制备药学活性化合物2-（4-氟苯氧基甲基）-5-（4-N-羟基脲基-1-丁炔基） - 四氢呋喃及其前体的新方法。