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1.发明授权Identifying randomly distributed microparticles in images to sequence a polynucleotide 有权识别图像中随机分布的微粒以对多核苷酸进行排序公开(公告)号：US09135497B2
公开(公告)日：2015-09-15
申请号：US13359950
申请日：2012-01-27
IPC分类号： G01N33/48 , G06K9/00 , C12Q1/68 , C12M1/34 , G06K9/20 , G06K9/32 , G06K9/34 , G06K9/36 , G06F19/22
CPC分类号： G06K9/00147 , G06F19/22 , G06K9/00577
摘要： Performing sequencing of a polynucleotide. A first image of microparticles that are distributed in a random fashion on a substrate may be received. Each of the microparticles may include a plurality of similar oligonucleotides of the polynucleotide. A second image of the microparticles may be received. A plurality of first subportions of the first image may be determined. Each subportion may include a respective plurality of microparticles distributed in a random fashion. The second image may be analyzed to identify a plurality of second subportions in the second image. Each of the plurality of second subportions may correspond to a respective one of the plurality of first subportions. A plurality of the microparticles may be matched from the first and second images based on said analyzing. At least a portion of the sequence of nucleotides of the polynucleotide may be determined based on said matching.
摘要翻译： 进行多核苷酸的测序。 可以接收在衬底上以随机方式分布的微粒的第一图像。 每个微粒可以包括多个与多核苷酸相似的寡核苷酸。 可以接收微粒的第二图像。 可以确定第一图像的多个第一子部分。 每个子部分可以包括以随机方式分布的相应的多个微粒。 可以分析第二图像以识别第二图像中的多个第二子部分。 多个第二子部分中的每一个可以对应于多个第一子部分中的相应一个。 基于所述分析，可以从第一和第二图像匹配多个微粒。 可以基于所述匹配来确定多核苷酸的核苷酸序列的至少一部分。
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公开(公告)号：US07374152B2
公开(公告)日：2008-05-20
申请号：US10821987
申请日：2004-04-12
申请人： Bu Qing Ruan
发明人： Bu Qing Ruan
IPC分类号： B25B25/00
CPC分类号： B60P7/083 , B60P7/0861 , Y10T24/2175 , Y10T29/49826
摘要： A binding machine includes a tightening mechanism adapted to tension a belt and a limiting mechanism adapted to limit tensioning of the belt. The tightening mechanism includes, for example, a ratchet and a pawl coupled to a body of the tightening mechanism. A handle is adapted to rotate the ratchet in a first direction in response to a first force applied to the handle. The pawl is adapted to prevent the ratchet from returning in a second direction when the first force is released. A spring mechanism allows the handle to indicate when a second force opposing the first force achieves an established magnitude.
摘要翻译： 装订机包括适于张紧皮带的紧固机构和适于限制皮带张紧的限制机构。 紧固机构包括例如棘轮和联接到紧固机构的主体的棘爪。 手柄适于响应于施加到手柄的第一力而在第一方向上旋转棘轮。 当第一力被释放时，棘爪适于防止棘轮在第二方向上返回。 弹簧机构允许手柄指示何时与第一力相反的第二力达到建立的大小。
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3.发明申请Identifying Microparticles in a Plurality of Images to Perform Polynucleotide Sequencing 有权识别多个图像中的微粒以进行多核苷酸测序公开(公告)号：US20130196330A1
公开(公告)日：2013-08-01
申请号：US13359950
申请日：2012-01-27
CPC分类号： G06K9/00147 , G06F19/22 , G06K9/00577
摘要： Performing sequencing of a polynucleotide. A first image of microparticles that are distributed in a random fashion on a substrate may be received. Each of the microparticles may include a plurality of similar oligonucleotides of the polynucleotide. A second image of the microparticles may be received. A plurality of first subportions of the first image may be determined. Each subportion may include a respective plurality of microparticles distributed in a random fashion. The second image may be analyzed to identify a plurality of second subportions in the second image. Each of the plurality of second subportions may correspond to a respective one of the plurality of first subportions. A plurality of the microparticles may be matched from the first and second images based on said analyzing. At least a portion of the sequence of nucleotides of the polynucleotide may be determined based on said matching.
摘要翻译： 进行多核苷酸的测序。 可以接收在衬底上以随机方式分布的微粒的第一图像。 每个微粒可以包括多个与多核苷酸相似的寡核苷酸。 可以接收微粒的第二图像。 可以确定第一图像的多个第一子部分。 每个子部分可以包括以随机方式分布的相应的多个微粒。 可以分析第二图像以识别第二图像中的多个第二子部分。 多个第二子部分中的每一个可以对应于多个第一子部分中的相应一个。 基于所述分析，可以从第一和第二图像匹配多个微粒。 可以基于所述匹配来确定多核苷酸的核苷酸序列的至少一部分。
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公开(公告)号：US20080201922A1
公开(公告)日：2008-08-28
申请号：US12012649
申请日：2008-02-04
申请人： Bu Qing Ruan
发明人： Bu Qing Ruan
IPC分类号： B25B25/00
CPC分类号： B60P7/083 , B60P7/0861 , Y10T24/2175 , Y10T29/49826
摘要： A binding machine includes a tightening mechanism adapted to tension a belt and a limiting mechanism adapted to limit tensioning of the belt. The tightening mechanism includes, for example, a ratchet and a pawl coupled to a body of the tightening mechanism. A handle is adapted to rotate the ratchet in a first direction in response to a first force applied to the handle. The pawl is adapted to prevent the ratchet from returning in a second direction when the first force is released. A spring mechanism allows the handle to indicate when a second force opposing the first force achieves an established magnitude.
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