公开(公告)号：US20060110801A1

公开(公告)日：2006-05-25

申请号：US09970076

申请日：2001-10-03

申请人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

发明人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

IPC分类号： C07H21/04 ,  C12N15/74 ,  C12N1/21 ,  C07K14/32 ,  C07K14/705

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

公开(公告)号：US20060083746A1

公开(公告)日：2006-04-20

申请号：US11047224

申请日：2005-01-31

申请人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

发明人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

IPC分类号： A61K39/40 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21 ,  C07K14/32

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

公开(公告)号：US5520036A

公开(公告)日：1996-05-28

申请号：US152984

申请日：1993-11-15

申请人： Michael R. Collier

发明人： Michael R. Collier

IPC分类号： A44B15/00

CPC分类号： A44B15/002 ,  A44D2200/12 ,  Y10S24/38 ,  Y10T24/45026 ,  Y10T70/8676 ,  Y10T70/8757

摘要： A group of several identical interconnected but separable key ring support members arranged as a composite structure. Each of the support members has a respective attached key ring. Each support member has two separate attachment parts at different locations on said member for directly connecting it to one or more members of said group by manually pressing the several members together. Manually releasable interlocking attachment parts enable one or more of the key ring support members to be selectively separated from the composite structure.

摘要翻译： 一组几个相互连接但可分离的键环支撑构件，被布置为复合结构。 每个支撑构件具有相应的附接的键环。 每个支撑构件在所述构件上的不同位置具有两个单独的附接部分，用于通过手动地将多个构件压在一起而将其直接连接到所述组的一个或多个构件。 手动可释放的互锁附接部件使得一个或多个键环支撑构件能够与复合结构选择性地分离。

公开(公告)号：US5468184A

公开(公告)日：1995-11-21

申请号：US136564

申请日：1993-10-13

申请人： William R. Collier

发明人： William R. Collier

IPC分类号： F24F7/08 ,  F24F13/072

CPC分类号： F24F7/08 ,  F24F13/072 ,  F24F2007/004

摘要： A forced air circulation system for an enclosed room with a floor, room walls, and a ceiling. The system includes at least one distributor unit positioned adjacent the base of at least one of the room walls. The distributor unit has an elongated center section, an inlet opening for receiving forced circulation air, and an elongated outlet passage of smaller cross-sectional area than that of the inlet opening. The system also provides a deflector unit positioned on the room wall substantially upwardly of the distributor outlet passage. The deflector unit has surface portions approximately parallel and perpendicular to the wall surface as well as a transition portion connecting these surfaces. Supply and return conduits are provided for directing forced air to the distributor unit inlet and withdrawing the circulated air from the room.

摘要翻译： 用于带有地板，房间墙壁和天花板的封闭房间的强制空气循环系统。 该系统包括至少一个位于邻近至少一个房间壁的底部的分配器单元。 分配器单元具有细长的中心部分，用于接收强制循环空气的入口和与入口开口相比较小的横截面面积的细长出口通道。 该系统还提供了一个偏转器单元，其定位在分配器出口通道上基本向上的房间壁上。 偏转器单元具有大致平行且垂直于壁表面的表面部分以及连接这些表面的过渡部分。 供应和返回管道用于将强制空气引导到分配器单元入口并从室内排出循环空气。

公开(公告)号：US5387383A

公开(公告)日：1995-02-07

申请号：US166071

申请日：1993-12-13

申请人： John R. Collier ,  Billie J. Collier

发明人： John R. Collier ,  Billie J. Collier

IPC分类号： D01F8/02 ,  D01F8/12 ,  D01F8/14 ,  B05D3/10 ,  B05D7/02

CPC分类号： D01F8/14 ,  D01F8/02 ,  D01F8/12 ,  D06M13/1845 ,  D06M13/203 ,  D06M15/05 ,  Y10T428/2924 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2933 ,  Y10T428/2965

摘要： Rayon/nylon and other sheath/core composite fibers or other materials, with good adhesion between sheath and core resulting from an adhesion promoter. The adhesion promoter is difunctional and sterically hindered. Fumaric acid and terephthalic acid are preferred adhesion promoters for the composite fibers or other materials, because each compound has both difunctionality and steric hinderance, allowing either to form covalent bonds to both the sheath and the core. Fibers produced in accordance with this invention may be used to produce fabrics which have the strength and wrinkle resistance shown by a number of synthetic fibers, but with the water absorption characteristics of natural fibers such as cotton.

摘要翻译： 人造丝/尼龙等护套/芯复合纤维或其他材料，由粘合促进剂产生的鞘和芯之间具有良好的附着力。 粘合促进剂是双官能的并且是空间位阻的。 富马酸和对苯二甲酸是复合纤维或其他材料的优选粘合促进剂，因为每种化合物都具有双官能性和空间阻碍性，允许与鞘和芯形成共价键。 根据本发明生产的纤维可用于生产具有许多合成纤维所示的强度和抗皱性能，但具有天然纤维如棉花的吸水性能的织物。

公开(公告)号：US5261257A

公开(公告)日：1993-11-16

申请号：US828242

申请日：1992-01-30

申请人： Michael R. Collier

发明人： Michael R. Collier

IPC分类号： A44B15/00

CPC分类号： A44B15/002 ,  A44D2200/12 ,  Y10S24/38 ,  Y10T24/45026 ,  Y10T70/8676 ,  Y10T70/8757

摘要： A key holder comprising two identically shaped parts each having a retainer for a plurality of apertured keys, the holder having at least one pair of mating latching structures holding the parts together when engaged and permitting the parts to be separated by only manually pulling the parts apart. Each latching structure includes a combination of a protuberance on one part and a cooperating protuberance-retaining recess on the other part. Each part has at least three distinct layers with first and second of the layers being thin flat and parallel and defining a space therebetween and a third layer offset with respect to the first and second layers. The third layer of each part lies parallel to and between the first and second layers of the other part with each third layer having a protuberance on one or both of its opposite faces, which protuberances are received in and retained by respective recesses in opposing faces of the first and second layers of the other part.

摘要翻译： 一种钥匙架，其包括两个相同形状的部件，每个部件具有用于多个有孔键的保持器，所述保持器具有至少一对配合的闩锁结构，当接合时将所述部件保持在一起，并且允许通过仅手动地将部件分开来分离部件 。 每个闩锁结构包括在一个部件上的突起和在另一部分上的配合突起保持凹部的组合。 每个部分具有至少三个不同的层，其中第一和第二层是薄平坦且平行的，并且在其间限定一个空间，并且相对于第一和第二层偏移的第三层。 每个部分的第三层平行于另一部分的第一和第二层之间并且在其中的第一和第二层之间，每个第三层在其相对的面中的一个或两个上具有突起，该突起被容纳在相应的凹槽中 另一部分的第一和第二层。

公开(公告)号：US5219508A

公开(公告)日：1993-06-15

申请号：US651667

申请日：1991-02-06

申请人： John R. Collier ,  Billie J. Collier

发明人： John R. Collier ,  Billie J. Collier

IPC分类号： D01F8/00 ,  D01F8/02

CPC分类号： D01F8/02 ,  D01F8/00 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2933 ,  Y10T428/2964 ,  Y10T428/2965 ,  Y10T428/2967 ,  Y10T428/2969 ,  Y10T428/2978

摘要： A sheath core fiber having an inner continuous core made from an oriented thermoplastic material, such as polyester, nylon, acrylic, and olefin, and a sheath made of a nonthermoplastic material, such as regenerated cellulose and protein. The fiber maintains the crease and tear resistance of the core material, yet has the water sorptivity and dyeability of the sheath material.A method of manufacturing such a fiber is also disclosed.

摘要翻译： 具有由定向热塑性材料制成的内部连续芯体（例如聚酯，尼龙，丙烯酸和烯烃）以及由非热塑性材料（例如再生纤维素和蛋白质）制成的护套的护芯芯纤维。 纤维保持芯材的折痕和抗撕裂性，但具有护套材料的水吸附性和染色性。 还公开了制造这种纤维的方法。

公开(公告)号：US4874127A

公开(公告)日：1989-10-17

申请号：US119805

申请日：1987-11-12

申请人： William R. Collier

发明人： William R. Collier

IPC分类号： F24F3/044 ,  F24F13/068

CPC分类号： F24F3/044 ,  F24F13/068 ,  H05K7/20745

摘要： A multi-level access flooring system having a work area floor and at least one intermediate floor, defining at least one isolated wireway between the intermediate floor and the work area floor, and at least one relatively unobstructed plenum, between the intermediate floor and the building floor, together with at least one HVAC inlet to such plenum and a plurality of individual outlets, with each outlet having its own flow control damper, together with a suitable control system for positioning the individual dampers and regulating the heating/cooling load of the HVAC unit to achieve localized as well as generalized control of climate within a building room.

摘要翻译： 一种具有工作区域地板和至少一个中间地板的多层通道地板系统，其在中间地板和工作区域地板之间限定至少一个隔离的线槽，以及在中间楼层和建筑物之间的至少一个相对无障碍的通风室 与至少一个HVAC入口连接到这样的集气室和多个单独的出口，每个出口具有其自己的流量控制阻尼器，以及用于定位各个阻尼器并调节HVAC的加热/冷却负载的合适的控制系统 在建筑室内实现局部化和全面控制气候的单位。

公开(公告)号：US4680156A

公开(公告)日：1987-07-14

申请号：US786441

申请日：1985-10-11

申请人： John R. Collier

发明人： John R. Collier

IPC分类号： B29C47/00 ,  B29C47/02 ,  B29C47/86

CPC分类号： B29C47/86 ,  B29C47/0004 ,  B29C47/02 ,  B29C47/822 ,  B29C47/862 ,  B29C47/864 ,  B29C47/866 ,  B29C47/0016 ,  B29K2995/005

摘要： A composite extrusion, such as a fiber, film or ribbon, having an inner core and an outer sheath, wherein the inner core is made of a molecularly oriented polymer capable of being rigidified by imposition of a temperature gradient and the sheath is made of a polymer wherein its molecules are generally not oriented. A method of making such a composite extrusion utilizing melt transformation coextrusion wherein the inner core-forming material is caused to assume a molecular orientation coaxial to the longitudinal axis of said core while in a molten state and then forced through a reducing die while being subjected to a temperature gradient while surrounded by the liquid sheath-forming material such that crystallization in at least the outer skin of said core occurs within the die but the sheath-forming material does not crystallize until the extrudate exits the die.

摘要翻译： 具有内核和外护套的复合挤出物，例如纤维，膜或带，其中内芯由能够通过施加温度梯度而被硬化的分子取向聚合物制成，并且护套由 聚合物，其中其分子通常不取向。 使用熔融相变共挤出制造这种复合挤出的方法，其中使内芯形成材料在熔融状态下呈现与所述芯的纵向轴线同轴的分子取向，然后在经受还原模的同时被迫通过还原模 温度梯度，同时被液体鞘形成材料包围，使得至少在芯中的外皮的结晶发生在模具内，但是鞘形成材料不会结晶直到挤出物离开模具。

公开(公告)号：USD325546S

公开(公告)日：1992-04-21

申请号：US321532

申请日：1989-03-09

申请人： Michael R. Collier

设计人： Michael R. Collier