公开(公告)号：US20240050592A1

公开(公告)日：2024-02-15

申请号：US18265376

申请日：2021-12-08

申请人： REPAIR BIOTECHNOLOGIES, INC.

发明人： Mourad Topors ,  Reason ,  Guilherme Cherman Perdigao de Oliveira ,  Marc Ridilla ,  David Mackenzie-Liu ,  Garrett Strough

IPC分类号： A61K48/00 ,  C07K14/415 ,  C07K14/705 ,  C07K14/47 ,  A61P3/06 ,  A61K38/17 ,  A61K38/44 ,  C12N15/85 ,  C12N9/02 ,  C12N5/071

CPC分类号： A61K48/0058 ,  C07K14/415 ,  C07K14/705 ,  C07K14/4705 ,  A61P3/06 ,  A61K38/1709 ,  A61K38/443 ,  C12N15/85 ,  C12N9/0081 ,  C12Y114/15006 ,  C12N5/0686 ,  C07K2319/50 ,  C12N2800/107

摘要： Disclosed herein are compositions, methods, and systems for enhancing cholesterol degradation in a cell, tissue, or organism. In many embodiments, the disclosure describes the use of one or more proteins, or sequences coding therefor, to enhance flow of cholesterol into the mitochondrion, where the cholesterol is degraded by one or more proteins comprising bacteria-related sequences. The compositions, methods, and systems disclosed herein are useful in the prevention or treatment of diseases, disorders, and conditions associated with high levels of cholesterol in the blood or cells of a patient.

公开(公告)号：US20240075108A1

公开(公告)日：2024-03-07

申请号：US18269869

申请日：2021-12-29

申请人： REPAIR BIOTECHNOLOGIES, INC.

发明人： Mourad Topors ,  Reason ,  Guilherme Cherman Perdigao de Oliveira ,  Marc Ridilla ,  David Mackenzie-Liu ,  Garrett Strough

IPC分类号： A61K38/44 ,  A61K31/44 ,  A61K31/47 ,  A61K38/17 ,  A61K38/52 ,  A61P35/00

CPC分类号： A61K38/443 ,  A61K31/44 ,  A61K31/47 ,  A61K38/17 ,  A61K38/52 ,  A61P35/00 ,  C12Y101/01146 ,  C12Y101/01147 ,  C12Y101/03006 ,  C12Y103/99004 ,  C12Y114/14001 ,  C12Y503/03001

摘要： The disclosed compositions, methods, and systems are useful in treating and preventing various cancers associated with buildup of mitochondrial cholesterol. In many embodiments, the disclosed compositions, methods, and systems may improve the efficacy and cytotoxicity of chemotherapeutic compounds, for example increasing cellular sensitivity to chemotherapy and/or reducing or preventing resistance. In many embodiments, the cancer may be early or late stage hepatocellular carcinoma.

公开(公告)号：US20210268019A1

公开(公告)日：2021-09-02

申请号：US17187509

申请日：2021-02-26

申请人： Repair Biotechnologies, Inc.

发明人： Mourad Topors ,  Reason ,  Guilherme Cherman Perdigão de Oliveira ,  Marc Ridilla ,  Jayanta Mukherjee ,  David Mackenzie-Liu ,  Garrett Strough ,  David Thomas

IPC分类号： A61K35/12 ,  C12N9/04 ,  C12N15/86 ,  C12N15/52

摘要： Disclosed herein are compositions, constructs, cassettes, vectors, cells, nucleic acids, peptides, proteins, protocols and methods for reducing cholesterol and lipid buildup in mammalian subjects, via gene and/or cell therapeutic treatments. In many embodiments, the disclosed compositions, cells, constructs, cassettes, vectors, nucleic acids, peptides, proteins, protocols and methods may help to reduce lipid levels in mammals. In one embodiment, the disclosed compositions, cells, constructs, cassettes, vectors, nucleic acids, peptides, proteins, protocols and methods are useful in reducing lipid build-up, especially cholesterol, in liver cells.