公开(公告)号：US20230192717A1

公开(公告)日：2023-06-22

申请号：US17926214

申请日：2021-05-19

申请人： RODEO THERAPEUTICS CORPORATION ,  Case Western Reserve University ,  Board of Regents of the University of Texas System

发明人： Stephen L Gwaltney ,  Joseph Ready ,  Monika Antczak ,  Sanford Markowitz ,  Amar Desai ,  Stanton Gerson

IPC分类号： C07D495/04 ,  A61K45/06 ,  C07D519/00

CPC分类号： C07D495/04 ,  A61K45/06 ,  C07D519/00

摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US20230039604A1

公开(公告)日：2023-02-09

申请号：US17296055

申请日：2019-11-21

申请人： RODEO THERAPEUTICS CORPORATION ,  Case Western Reserve University ,  Board of Regents of the University of Texas System

发明人： Sanford MARKOWITZ ,  Joseph READY ,  Stephen L. GWALTNEY, II ,  Monika ANTCZAK

IPC分类号： A61K31/4365 ,  C07D495/04 ,  C07D519/00 ,  A61K31/519 ,  A61K31/506 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/437 ,  A61K45/06

摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.