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公开(公告)号：US20250069706A1
公开(公告)日：2025-02-27
申请号：US18729385
申请日：2023-01-30
Inventor： Bo LI
Abstract: A novel framework to transform a T-cell receptor (TCR) repertoire sample into a fixed-length vector. Short peptide sequences with different lengths in each TCR may be encoded into a numeric vector with fixed dimensions. A large amount of existing TCRs from healthy individuals may be pooled to generate a distribution of the encoding vector in a high-dimensional Euclidean space. Unsupervised clustering may be performed on the “points” in this space (each point is a TCR) to group them into antigen-specific clusters. The centroid of each cluster may be defined as a repertoire functional unit (“RFU”). For a new TCR repertoire sample, each TCR may be assigned to its most similar RFU group, and the RFU counts may be normalized by the number of sequences in the repertoire. The output data may be a fixed-length RFU vector, with each number representing the relative abundance of the given RFU in the repertoire.
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公开(公告)号：US12237051B2
公开(公告)日：2025-02-25
申请号：US18505757
申请日：2023-11-09
Applicant: University of Central Florida Research Foundation, Inc. , The Board of Regents of the University of Texas System
Inventor： Degui Zhi , Shaojie Zhang , Ardalan Naseri , Ahsan Sanaullah , Erwin Holzhauser
Abstract: A system for indexing, updating, and search haplotypes for genetic genealogical discovery in genotype databases. The system includes a pool of genetic indexes, a haplotype ingestion engine, and a haplotype query engine. The haplotypes of a number of individuals in a genotype database are indexed by a pool of multiple panels, and each panel pool can be dynamically updated by the insertion or deletion of individual haplotypes. A genetic genealogical search of a query haplotype against the database is achieved by first projecting the query onto a subset of panels in the pool, then conducting long match queries over each panel, and finally aggregating the identified long matches into Identical-by-Descent segments, i.e., DNA matches, between the query and the haplotypes in the database.
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公开(公告)号：US20250043952A1
公开(公告)日：2025-02-06
申请号：US18920280
申请日：2024-10-18
Inventor： Brian H. Dennis , Frederick M. MacDonnell
Abstract: A flow restrictor for use on burners used for combusting gases includes a central disk and opposing cylindrical members extending from opposing sides of the central disk. The central disk includes a central portion having multiple inner openings extending through the central disk and a peripheral portion having multiple outer openings extending through the central disk. Each of the opposing cylindrical members surrounds the central portion and the inner openings of the central disk. The peripheral portion and the outer openings of the central disk are disposed outside of the cylindrical members. Each of the cylindrical members is designed to be attached to an open end of a pipe of a burner.
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公开(公告)号：US12202895B2
公开(公告)日：2025-01-21
申请号：US17275838
申请日：2019-09-12
Inventor： Zhiqiang An , Chengcheng Zhang , Ningyan Zhang , Xun Gui , Mi Deng , Tao Huang , Qiang Liu , X. Charlene Liao
IPC: C07K16/28 , A61K39/395 , A61K45/06 , A61K47/68 , A61K47/69 , A61K51/10 , A61P35/02 , G01N33/574
Abstract: The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.
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公开(公告)号：US12161618B2
公开(公告)日：2024-12-10
申请号：US18093840
申请日：2023-01-06
Inventor： James B. Brugarolas , Haley Hill , Tao Wang
IPC: A61K31/135 , A61K31/275 , A61P35/00 , G01N33/50 , A61K45/06
Abstract: The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.
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Patent Agency Ranking
公开(公告)号：US20240398708A1
公开(公告)日：2024-12-05
申请号：US18540656
申请日：2023-12-14
Inventor： Shao-Ling HUANG , Melvin E. KLEGERMAN , Yong-Jian GENG , Hyunggun KIM , David D. MCPHERSON
Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.
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公开(公告)号：US20240395398A1
公开(公告)日：2024-11-28
申请号：US18749146
申请日：2024-06-20
Inventor： Hari Radhakrishnan , John B. Holcomb , Charles E. Wade , Bryan Cotton , Rondel Albarado , Drew Kraus , Joel Watts , Binod Shrestha , Laura J. Moore
Abstract: Embodiments disclosed herein provide a system, method, and computer program product for providing a patient dashboard system in a patient care setting. The patient dashboard system collects and stores patient data from a variety of sources. The collected patient data is filtered, analyzed, and displayed. The patient dashboard system displays patient data that is relevant to the treatment of the patient, including recommended medical actions and pertinent positives and pertinent negatives.
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公开(公告)号：US20240383999A1
公开(公告)日：2024-11-21
申请号：US17995214
申请日：2021-04-01
Inventor： Ningyan ZHANG , Zhiqiang AN , Zhiqiang KU , Hui DENG , Lingegowda S MANGALA , Anil K. SOOD
Abstract: Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.
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公开(公告)号：US20240376199A1
公开(公告)日：2024-11-14
申请号：US18691229
申请日：2022-09-13
Inventor： Zhiqiang AN , Ningyan ZHANG , Peng ZHAO
IPC: C07K16/28
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments etc., that specifically bind a TREM2 protein or a TREM2 protein epitope, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号：US12138479B2
公开(公告)日：2024-11-12
申请号：US17597509
申请日：2020-07-13
Inventor： Weiguo Lu , Xuejun Gu , Mingli Chen , Xun Jia , Steve Bin Jiang
IPC: A61N5/10
Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.
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