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公开(公告)号:US20140105915A1
公开(公告)日:2014-04-17
申请号:US14122391
申请日:2012-05-24
申请人: Paul Algate , Stephanie Jane Clegg , Jennifer L. Craigen , Paul Andrew Hamblin , Alan Peter Lewis , Patrick Mayes , Radha Shah Parmar , Trevor Anthony Kenneth Wattam
发明人: Paul Algate , Stephanie Jane Clegg , Jennifer L. Craigen , Paul Andrew Hamblin , Alan Peter Lewis , Patrick Mayes , Radha Shah Parmar , Trevor Anthony Kenneth Wattam
IPC分类号: C07K16/28
摘要: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
摘要翻译: 本发明涉及特异性结合B细胞成熟抗原(BCMA),特别是人BCMA(hBCMA)并且抑制BAFF和APRIL与BCMA受体结合的抗原结合蛋白及其片段。 进一步公开的是药物组合物,筛选和治疗方法。
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公开(公告)号:US20120070439A1
公开(公告)日:2012-03-22
申请号:US13322224
申请日:2010-05-26
CPC分类号: C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要: The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译: 本发明涉及适用于抗原结合蛋白的接头,某些抗原结合蛋白及其制备方法。
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公开(公告)号:US20110305693A1
公开(公告)日:2011-12-15
申请号:US13202998
申请日:2010-02-23
IPC分类号: A61K39/395 , C12N15/13 , C12N5/10 , C12N1/21 , C12N1/19 , A61P35/02 , C12P21/00 , A61P19/02 , A61P19/10 , A61P19/08 , A61P35/00 , C07K19/00 , C12N1/15
CPC分类号: C07K16/2875 , C07K16/248 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要: The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VHNL domain, methods of making such constructs and uses thereof.
摘要翻译: 本发明涉及RANKL拮抗剂与TNF-α拮抗剂的组合,并提供与RANKL结合的抗原结合构建体,其包含与一个或多个表位结合结构域连接的蛋白质支架,其中所述抗原结合构建体具有至少两个抗原结合 其中至少一个来自表位结合结构域并且其中至少一个来自配对VHNL结构域的位点,制备此类构建体的方法及其用途。
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公开(公告)号:US20110305692A1
公开(公告)日:2011-12-15
申请号:US13202996
申请日:2010-02-23
IPC分类号: A61K39/395 , C07K14/00 , A61K39/00 , A61P19/10 , A61P19/02 , C12N1/19 , A61P19/00 , C07H21/04 , C12P21/06 , C12N5/10 , C12N1/21 , C07K16/42 , A61P19/08
CPC分类号: C07K16/2875 , C07K16/241 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要: The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译: 本发明涉及RANKL拮抗剂与TNF-α拮抗剂的组合,并提供与RANKL结合的抗原结合构建体,其包含与一个或多个表位结合结构域连接的蛋白质支架,其中所述抗原结合构建体具有至少两个抗原结合 其中至少一个来自表位结合结构域并且其中至少一个来自配对的VH / VL结构域的位点,制备此类构建体的方法及其用途。
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公开(公告)号:US09394374B2
公开(公告)日:2016-07-19
申请号:US13322224
申请日:2010-05-26
CPC分类号: C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要: The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译: 本发明涉及适用于抗原结合蛋白的接头,某些抗原结合蛋白及其制备方法。
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公开(公告)号:US20130236467A1
公开(公告)日:2013-09-12
申请号:US13988375
申请日:2011-11-23
IPC分类号: C07K16/28
CPC分类号: C07K16/2863 , C07K16/22 , C07K16/247 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The invention relates to combinations of HGF-antagonists with VEGF antagonists, and provides antigen-binding proteins which bind to HGF comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding protein has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译: 本发明涉及HGF拮抗剂与VEGF拮抗剂的组合,并且提供与HGF结合的抗原结合蛋白,其包含与一个或多个表位结合结构域连接的蛋白质支架,其中所述抗原结合蛋白具有至少两个抗原结合 其中至少一个来自表位结合结构域并且其中至少一个来自配对的VH / VL结构域的位点,制备此类构建体的方法及其用途。
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公开(公告)号:US20110305694A1
公开(公告)日:2011-12-15
申请号:US13203003
申请日:2010-02-23
IPC分类号: A61K39/395 , C12N15/13 , C12N5/10 , C12N1/21 , A61P19/02 , C12N1/15 , C12P21/00 , A61P35/00 , A61P19/08 , C07K19/00 , C12N1/19
CPC分类号: C07K16/22 , C07K16/2875 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要: The invention relates to a combination of RANKL antagonists with OSM antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof
摘要翻译: 本发明涉及RANKL拮抗剂与OSM拮抗剂的组合,并提供与RANKL结合的抗原结合构建体,其包含与一个或多个表位结合结构域连接的蛋白质支架,其中所述抗原结合构建体具有至少两个抗原结合 其中至少一个来自表位结合结构域并且其中至少一个来自配对的VH / VL结构域的位点,制备此类构建体的方法及其用途
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