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公开(公告)号：US10150524B2
公开(公告)日：2018-12-11
申请号：US15960975
申请日：2018-04-24
IPC分类号： B62D63/02 , B60L11/18 , G05D1/02 , G05D1/00 , B60L11/00 , B62D31/02 , B60L5/38 , B60M1/30 , B60F5/02 , B62D27/06 , B60P3/42 , H02J7/00 , B64C39/02
摘要： A transport system has a wheeled, steerable, self-powered, self-navigating carrier vehicle, having a substantially planar support frame, an on-board, rechargeable, battery-based power system, control circuitry, including GPS circuitry, on-board the carrier vehicle, adapted to drive and steer the carrier vehicle, and an upward-facing carrier interface adapted to the support frame, the carrier interface having first physical engagement elements, and a passenger pod adapted to carry both packages and persons, the passenger pod having a structural framework, a rechargeable, battery-based power system, and a downward-facing pod interface adapted to the structural framework, the carrier interface having second physical engagement elements. The passenger pod, placed upon the carrier vehicle, engages the downward-facing pod interface to the upward-facing carrier interface by the first and second physical engagement elements.
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公开(公告)号：US10112728B2
公开(公告)日：2018-10-30
申请号：US15950018
申请日：2018-04-10
摘要： A charging system for a drone carrying a passenger pod has a base structure connected to a power grid, a row of substantially planar wireless charging pads supported by the base structure, and a computerized controller enabled to communicate with a drone and to initiate, control and stop charging power. As a drone carrying a passenger pod approaches the charging-system, the computerized controller directs the moving drone into a path bringing a charging receiver pad of the passenger pod carried by the drone, and connected to a battery of the passenger pod, into proximity with the row of substantially planar charging pads, and directs the drone to move the carried passenger pod along the row of charging pods, managing speed and direction of the moving drome along the path, as charging of the battery of the passenger pod is accomplished.
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公开(公告)号：US20180265098A1
公开(公告)日：2018-09-20
申请号：US15982339
申请日：2018-05-17
摘要： A transport system has a first set of substantially parallel rails supported above ground level by support structures, a trolley having wheels mounted to a frame with the wheels engaging the rails, at least one wheel powered to move the trolley along the set of rails, a portion of the frame depending between the rails to a level below the rails, and a downward-facing latching interface on the depending portion of the frame, and a pod enabled to carry a passenger or parcels, or both, engaged by an upward-facing latching interface to the downward-facing latching interface of the trolley, such that, as the trolley travels along the rail set, the pod is carried along below the rail set.
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公开(公告)号：US20180229859A1
公开(公告)日：2018-08-16
申请号：US15950018
申请日：2018-04-10
CPC分类号： B64F1/362 , B64C39/024 , B64C2201/042 , B64C2201/066 , B64C2201/128 , G05D1/0027 , G08G5/0013 , G08G5/0095 , H02J7/025
摘要： A charging system for a drone carrying a passenger pod has a base structure connected to a power grid, a row of substantially planar wireless charging pads supported by the base structure, and a computerized controller enabled to communicate with a drone and to initiate, control and stop charging power. As a drone carrying a passenger pod approaches the charging-system, the computerized controller directs the moving drone into a path bringing a charging receiver pad of the passenger pod carried by the drone, and connected to a battery of the passenger pod, into proximity with the row of substantially planar charging pads, and directs the drone to move the carried passenger pod along the row of charging pods, managing speed and direction of the moving drome along the path, as charging of the battery of the passenger pod is accomplished.
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公开(公告)号：US20140205604A1
公开(公告)日：2014-07-24
申请号：US14235330
申请日：2012-07-25
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD). diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
摘要翻译： 本发明涉及包含由抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体， 包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD）的用途。 糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜新生血管形成，以及编码所述抗原结合构建体的多核苷酸序列。
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公开(公告)号：US20230015158A1
公开(公告)日：2023-01-19
申请号：US17953057
申请日：2022-09-26
摘要： A vertiport exchange station has a plurality of vertical takeoff and landing (VTOL) air taxis, a plurality of landing/takeoff pads arranged in a rectangular pattern, a passenger terminal for arrival and departure of passengers, a plurality of electric motor driven chassis each adapted to carry a pod adapted to carry one or more passengers, a transfer path guiding the chassis in a closed loop, and a control system. One or more incoming passengers enter a pod at the passenger terminal, an air taxi is guided to a specific pad, the chassis carrying the pod is transported to a point near the specific pad, is guided to stop on the specific pad, the air taxi is guided to connect to the pod, the pod is detached from the chassis, and the air taxi is guided to ascend and to proceed to a programmed destination.
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公开(公告)号：US10808040B2
公开(公告)日：2020-10-20
申请号：US14239196
申请日：2012-08-13
申请人： Claire Ashman , Mary Birchler , Rudolf M. T. De Wildt , Claire Holland , Alan Peter Lewis , Peter Morley , Thomas Sandal , Michael Steward
发明人： Claire Ashman , Mary Birchler , Rudolf M. T. De Wildt , Claire Holland , Alan Peter Lewis , Peter Morley , Thomas Sandal , Michael Steward
IPC分类号： C07K16/00 , A61K39/395 , C07K16/42 , C07K16/28 , C07K16/22
摘要： The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.
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公开(公告)号：US10759286B2
公开(公告)日：2020-09-01
申请号：US16599514
申请日：2019-10-11
IPC分类号： B64F1/31 , B60P3/00 , B61B1/02 , B62D31/00 , B61B3/02 , B61B13/00 , B62D31/02 , B62D47/00 , B60M1/30 , E04H14/00 , B60L53/30 , B60L53/14 , B60L53/00 , B60L53/53 , H02J7/00
摘要： A method for transporting a person or a parcel from a first location to a second location involves mounting a pod having a rechargeable battery and a compartment to a first vehicle, moving the first vehicle with the pod mounted to a loading position at or near the first location, loading a person or a parcel into the pod, moving the first transporter vehicle from the loading position to a first exchange point, exchanging the passenger pod from the first transporter vehicle to a second transporter vehicle at the first exchange point by de-mounting the pod from the first transporter vehicle and mounting the pod to the second transporter vehicle by a compatible physical interface between the pod and the second transporter vehicle, and transporting the second transporter vehicle with the pod to the second location.
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公开(公告)号：US20200040598A1
公开(公告)日：2020-02-06
申请号：US16599514
申请日：2019-10-11
IPC分类号： E04H14/00 , B61B1/02 , B60P3/00 , B64F1/31 , B62D47/00 , B60L53/14 , B62D31/02 , B60L53/30 , B61B13/00 , B61B3/02 , B62D31/00
摘要： A method for transporting a person or a parcel from a first location to a second location involves mounting a pod having a rechargeable battery and a compartment to a first vehicle, moving the first vehicle with the pod mounted to a loading position at or near the first location, loading a person or a parcel into the pod, moving the first transporter vehicle from the loading position to a first exchange point, exchanging the passenger pod from the first transporter vehicle to a second transporter vehicle at the first exchange point by de-mounting the pod from the first transporter vehicle and mounting the pod to the second transporter vehicle by a compatible physical interface between the pod and the second transporter vehicle, and transporting the second transporter vehicle with the pod to the second location.
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公开(公告)号：US10286925B2
公开(公告)日：2019-05-14
申请号：US15982339
申请日：2018-05-17
摘要： A transport system has a first set of substantially parallel rails supported above ground level by support structures, a trolley having wheels mounted to a frame with the wheels engaging the rails, at least one wheel powered to move the trolley along the set of rails, a portion of the frame depending between the rails to a level below the rails, and a downward-facing latching interface on the depending portion of the frame, and a pod enabled to carry a passenger or parcels, or both, engaged by an upward-facing latching interface to the downward-facing latching interface of the trolley, such that, as the trolley travels along the rail set, the pod is carried along below the rail set.
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