Treatment of myocardial injury with humanin analogs
    4.
    发明授权
    Treatment of myocardial injury with humanin analogs 有权
    用人类类似物治疗心肌损伤

    公开(公告)号:US09034825B2

    公开(公告)日:2015-05-19

    申请号:US14186331

    申请日:2014-02-21

    IPC分类号: A61K38/17 C07K14/47

    摘要: Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.

    摘要翻译: 提供使用人源和人源化合物类似物来治疗显示或处于胰岛素抵抗风险的哺乳动物的方法,增加显示或有胰岛素抵抗风险的哺乳动物的胰岛素敏感性,治疗2型糖尿病,代谢综合征和神经变性,治疗和 预防心肌损伤,并确定寿命。

    Humanin Decreases Liver Fat and Visceral Fat Accumulation
    6.
    发明申请
    Humanin Decreases Liver Fat and Visceral Fat Accumulation 审中-公开
    人体减少肝脏脂肪和内脏脂肪积累

    公开(公告)号:US20130109635A1

    公开(公告)日:2013-05-02

    申请号:US13694176

    申请日:2012-11-02

    申请人: Radhika Muzumdar

    发明人: Radhika Muzumdar

    IPC分类号: A61K38/17

    摘要: Methods are provided for reducing visceral fat or reducing accumulation of visceral fat in a subject, or of reducing fat in a liver or reducing accumulation of fat in a liver of a subject, comprising administering a humanin or an active analog of humanin to the subject. Methods are also provided of increasing hepatic triglyceride secretion in a subject or of increasing hepatic microsomal triglyceride transfer protein (MTTP) expression in a subject.

    摘要翻译: 提供了用于减少内脏脂肪或减少受试者内脏脂肪积累或减少肝脏中脂肪或减少受试者肝脏中脂肪积累的方法,其包括对受试者施用人源激素或人类活性类似物。 还提供了在受试者中增加肝脏甘油三酯分泌或在受试者中增加肝微粒体甘油三酯转运蛋白(MTTP)表达的方法。