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1.发明授权公开(公告)号：US08828717B2
公开(公告)日：2014-09-09
申请号：US12946381
申请日：2010-11-15
发明人： Syed Kashmiri , Jeffrey Schlom , Eduardo A. Padlan
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
摘要翻译： 本公开提供与亲本抗体相比保留CEA结合亲和力的人源化COL-1单克隆抗体。 本文还公开了与亲本抗体相比具有降低的免疫原性的人源化COL-1单克隆抗体。 公开的人源化COL-1抗体包括用来自同源人序列的相应位置的残基取代框架残基。 在几个实施方案中，公开了使用人源化COL-1抗体检测或治疗受试者中表达CEA的肿瘤或细胞的方法。 还公开了包含本文所述的人源化COL-1抗体的试剂盒。
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公开(公告)号：US20110053264A1
公开(公告)日：2011-03-03
申请号：US12946381
申请日：2010-11-15
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
摘要翻译： 本公开提供与亲本抗体相比保留CEA结合亲和力的人源化COL-1单克隆抗体。 本文还公开了与亲本抗体相比具有降低的免疫原性的人源化COL-1单克隆抗体。 公开的人源化COL-1抗体包括用来自同源人序列的相应位置的残基取代框架残基。 在几个实施方案中，公开了使用人源化COL-1抗体检测或治疗受试者中表达CEA的肿瘤或细胞的方法。 还公开了包含本文所述的人源化COL-1抗体的试剂盒。
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3.发明申请公开(公告)号：US20080274055A1
公开(公告)日：2008-11-06
申请号：US11813092
申请日：2005-12-30
IPC分类号： A61K39/395 , C07K16/30 , G01N33/574 , A61K49/00 , C12N15/13 , C12N15/79 , C12N5/10 , A61P35/00
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
摘要翻译： 本公开提供与亲本抗体相比保留CEA结合亲和力的人源化COL-1单克隆抗体。 本文还公开了与亲本抗体相比具有降低的免疫原性的人源化COL-1单克隆抗体。 公开的人源化COL-1抗体包括用来自同源人序列的相应位置的残基取代框架残基。 在几个实施方案中，公开了在检测或治疗受试者中表达CEA的肿瘤或细胞的情况下使用人源化COL-1抗体的方法。 还公开了包含本文所述的人源化COL-1抗体的试剂盒。
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4.发明授权公开(公告)号：US07855276B2
公开(公告)日：2010-12-21
申请号：US11813092
申请日：2005-12-30
发明人： Syed Kasmiri , Jeffrey Schlom , Eduardo A. Padlan
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00 , G01N33/53
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
摘要翻译： 本公开提供与亲本抗体相比保留CEA结合亲和力的人源化COL-1单克隆抗体。 本文还公开了与亲本抗体相比具有降低的免疫原性的人源化COL-1单克隆抗体。 公开的人源化COL-1抗体包括用来自同源人序列的相应位置的残基取代框架残基。 在几个实施方案中，公开了使用人源化COL-1抗体检测或治疗受试者中表达CEA的肿瘤或细胞的方法。 还公开了包含本文所述的人源化COL-1抗体的试剂盒。
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