公开(公告)号：US20110046074A1

公开(公告)日：2011-02-24

申请号：US12745692

申请日：2008-12-04

Applicant: Manish Kumar ,  Mark Clark ,  Julie M. Zilles ,  Mariusz Grzelakowski ,  Rainer Nehring ,  WolfGang Meier

Inventor： Manish Kumar ,  Mark Clark ,  Julie M. Zilles ,  Mariusz Grzelakowski ,  Rainer Nehring ,  WolfGang Meier

IPC: A61K38/17 ,  C08G77/20 ,  C08L89/00 ,  C02F1/68

CPC classification number: B01D71/78 ,  B01D67/0006 ,  B01D69/144 ,  B01D71/58 ,  B01D71/70 ,  B01D71/80 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2323/345

Abstract: Provided are substantially flat membranes that include a block or graft co-polymer and a water transport protein, such as Aquaporin-Z, or a synthetic mimic of such proteins. Also provided are methods of removing contaminants from a liquid, by contacting the liquid with a substantially flat membrane that includes a block or graft co-polymer and a water transport protein or synthetic mimic thereof. Also provided are methods of making such membranes. Further provided are compositions that include at least one active ingredient and vesicles surrounding the active ingredient, where the vesicles include a block or graft copolymer and a water transport protein or synthetic mimic surrounding the active ingredient. Also provided are methods that include administering such compositions to patients.

Abstract translation: 提供了基本上平坦的膜，其包括块或接枝共聚物和水输送蛋白，例如水通道蛋白-Z，或这种蛋白质的合成模拟物。 还提供了通过使液体与包括嵌段或接枝共聚物和水输送蛋白质或其合成模拟物的基本上平坦的膜接触来从液体中除去污染物的方法。 还提供制造这种膜的方法。 还提供了包含至少一种活性成分和围绕活性成分的囊泡的组合物，其中囊泡包括嵌段或接枝共聚物，水运输蛋白或围绕活性成分的合成模拟物。 还提供了包括向患者施用这样的组合物的方法。

公开(公告)号：US08378003B2

公开(公告)日：2013-02-19

申请号：US12745692

申请日：2008-12-04

Applicant: Kumar Manish ,  Clark Mark ,  Zilles L. Julie ,  Mariusz Grzelakowski ,  Rainer Nehring ,  WolfGang Meier

Inventor： Kumar Manish ,  Clark Mark ,  Zilles L. Julie ,  Mariusz Grzelakowski ,  Rainer Nehring ,  WolfGang Meier

IPC: C08F2/46 ,  C08F2/42 ,  C08J3/28 ,  B01D39/14

CPC classification number: B01D71/78 ,  B01D67/0006 ,  B01D69/144 ,  B01D71/58 ,  B01D71/70 ,  B01D71/80 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2323/345

Abstract: Provided are substantially flat membranes that include a block or graft co-polymer and a water transport protein, such as Aquaporin-Z, or a synthetic mimic of such proteins. Also provided are methods of removing contaminants from a liquid, by contacting the liquid with a substantially flat membrane that includes a block or graft co-polymer and a water transport protein or synthetic mimic thereof. Also provided are methods of making such membranes. Further provided are compositions that include at least one active ingredient and vesicles surrounding the active ingredient, where the vesicles include a block or graft copolymer and a water transport protein or synthetic mimic surrounding the active ingredient. Also provided are methods that include administering such compositions to patients.

Abstract translation: 提供了基本上平坦的膜，其包括块或接枝共聚物和水输送蛋白，例如水通道蛋白-Z，或这种蛋白质的合成模拟物。 还提供了通过使液体与包括嵌段或接枝共聚物和水输送蛋白质或其合成模拟物的基本上平坦的膜接触来从液体中除去污染物的方法。 还提供制造这种膜的方法。 还提供了包含至少一种活性成分和围绕活性成分的囊泡的组合物，其中囊泡包括嵌段或接枝共聚物以及围绕活性成分的水转运蛋白或合成的模拟物。 还提供了包括向患者施用这样的组合物的方法。