公开(公告)号：US07893223B2

公开(公告)日：2011-02-22

申请号：US11165793

申请日：2005-06-24

申请人： Giovanni Battista Giovenzana ,  Giovanni Palmisano ,  Massimo Sisti ,  Camilla Cavallotti ,  Silvio Aime ,  Luisella Calabi ,  Rolf Swenson ,  Ramalingam Kondareddiar ,  Luciano Lattuada ,  Pierfrancesco Morosini

发明人： Giovanni Battista Giovenzana ,  Giovanni Palmisano ,  Massimo Sisti ,  Camilla Cavallotti ,  Silvio Aime ,  Luisella Calabi ,  Rolf Swenson ,  Ramalingam Kondareddiar ,  Luciano Lattuada ,  Pierfrancesco Morosini

IPC分类号： C07F13/00

CPC分类号： C07C209/62 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/106 ,  A61K49/122 ,  A61K49/14 ,  A61K51/088 ,  C07D243/08 ,  C07D243/14 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/4816 ,  C07F9/645 ,  C07C211/50

摘要： Compounds of general formula (I): with substituents as defined herein and their chelates with bi-trivalent ions of the metal elements of atomic numbers 20 to 31, 39, 42, 43, 44, 49, and 57 to 83, and radioisotopes chosen among 203Pb, 67Ga, 68Ga, 72As, 111In, 113In, 90Y, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 140La, 175Yb, 153Sm, 166Ho, 149Pm, 177Lu, 142Pr, 159Gd, 212Bi, 47Sc, 149Pm, 67Cu, 111Ag, 199Au, 161Tb, 51Cr, 167Tm, 141Ce, 168Yb, 88Y, 165Dy, 166Dy, 97Ru, 103Ru, 186Re, 99mTc, 211Bi, 213Bi, 214Bi, 105Rh, 109Pd, 177mSn, 177Sn and 199Au, as well as the salts thereof with physiologically compatible bases or acids.

摘要翻译： 通式（I）的化合物：具有如本文所定义的取代基及其与原子序数为20至31,39,42,43,44,49和57至83的金属元素的双三价离子的螯合物和选择的放射性同位素 在203Pb，67Ga，68Ga，72As，111In，113In，90Y，97Ru，62Cu，64Cu，52Fe，52mMn，140La，175Yb，153Sm，166Ho，149Pm，177Lu，142Pr，159Gd，212Bi，47Sc，149Pm，67Cu，111Ag ，199Au，161Tb，51Cr，167Tm，141Ce，168Yb，88Y，165Dy，166Dy，97Ru，103Ru，186Re，99mTc，211Bi，213Bi，214Bi，105Rh，109Pd，177mSn，177Sn和199Au， 生理相容的碱或酸。

公开(公告)号：US20060034773A1

公开(公告)日：2006-02-16

申请号：US11165793

申请日：2005-06-24

申请人： Giovanni Giovenzana ,  Giovanni Palmisano ,  Massimo Sisti ,  Camilla Cavallotti ,  Silvio Aime ,  Luisella Calabi ,  Rolf Swenson ,  Ramalingam Kondareddiar ,  Luciano Lattuada ,  Pierfrancesco Morosini

发明人： Giovanni Giovenzana ,  Giovanni Palmisano ,  Massimo Sisti ,  Camilla Cavallotti ,  Silvio Aime ,  Luisella Calabi ,  Rolf Swenson ,  Ramalingam Kondareddiar ,  Luciano Lattuada ,  Pierfrancesco Morosini

IPC分类号： A61K49/10 ,  C07F9/22

CPC分类号： C07C209/62 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/106 ,  A61K49/122 ,  A61K49/14 ,  A61K51/088 ,  C07D243/08 ,  C07D243/14 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/4816 ,  C07F9/645 ,  C07C211/50

摘要： Compounds of general formula (I): in which: R1 through R5 are as defined in the specification FG, which can be the same or different, are carboxy, —PO3H2 or —RP(O)OH groups, wherein R is hydrogen, or an optionally substituted group selected from C1-C20 alkyl, C3-C10 cycloalkyl, C4-C20 cycloalkylalkyl, aryl, arylalkyl, a group bearing an acidic moiety, and a group bearing an amino moiety, each of which may be further optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203Pb, 67Ga, 68Ga, 72As, 111In, 113In, 90Y, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 140La, 175Yb, 153Sm, 166Ho, 149Pm, 177Lu, 142Pr, 159Gd, 212Bi, 47Sc, 149Pm, 67Cu, 111Ag, 199Au, 161Tb, 51Cr, 167Tm, 141Ce, 168Yb, 88Y, 165Dy, 166Dy, 97Ru, 103Ru, 186Re, 188Re, 99mTc, 211Bi, 212Bi, 213Bi, 214Bi, 105Rh, 109Pd, 117mSn, 177Sn and 199Au, as well as the salts thereof with physiologically compatible bases or acids.