公开(公告)号：US08399433B2

公开(公告)日：2013-03-19

申请号：US12791047

申请日：2010-06-01

Applicant: Rama Devi Appari ,  Xin Chen ,  Ramesh Chilukuri ,  Andrew P. Crew ,  Hanqing Dong ,  Caterina Ferraro ,  Kenneth Foreman ,  Ramesh C. Gupta ,  An-Hu Li ,  Dan Sherman ,  Kathryn M. Stolz ,  Brian Volk ,  Robert Zahler

Inventor： Rama Devi Appari ,  Xin Chen ,  Ramesh Chilukuri ,  Andrew P. Crew ,  Hanqing Dong ,  Caterina Ferraro ,  Kenneth Foreman ,  Ramesh C. Gupta ,  An-Hu Li ,  Dan Sherman ,  Kathryn M. Stolz ,  Brian Volk ,  Robert Zahler

IPC: A61K31/675 ,  C07D279/10 ,  C07D413/12 ,  C07F9/08

CPC classification number: C07F9/65583 ,  A61K31/497 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07F9/6512 ,  C07F9/6544

Abstract: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.