公开(公告)号：US08399433B2

公开(公告)日：2013-03-19

申请号：US12791047

申请日：2010-06-01

Applicant: Rama Devi Appari ,  Xin Chen ,  Ramesh Chilukuri ,  Andrew P. Crew ,  Hanqing Dong ,  Caterina Ferraro ,  Kenneth Foreman ,  Ramesh C. Gupta ,  An-Hu Li ,  Dan Sherman ,  Kathryn M. Stolz ,  Brian Volk ,  Robert Zahler

Inventor： Rama Devi Appari ,  Xin Chen ,  Ramesh Chilukuri ,  Andrew P. Crew ,  Hanqing Dong ,  Caterina Ferraro ,  Kenneth Foreman ,  Ramesh C. Gupta ,  An-Hu Li ,  Dan Sherman ,  Kathryn M. Stolz ,  Brian Volk ,  Robert Zahler

IPC: A61K31/675 ,  C07D279/10 ,  C07D413/12 ,  C07F9/08

CPC classification number: C07F9/65583 ,  A61K31/497 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07F9/6512 ,  C07F9/6544

Abstract: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

公开(公告)号：US20090274746A1

公开(公告)日：2009-11-05

申请号：US12401175

申请日：2009-03-10

Applicant: Ramesh C. Gupta ,  Manicka V. Vadhanam

Inventor： Ramesh C. Gupta ,  Manicka V. Vadhanam

IPC: A61K9/00 ,  A61K31/12 ,  A61K31/05 ,  A61K31/404 ,  A61K31/497 ,  A61K31/355 ,  A61K31/122 ,  A61K31/352 ,  A61K31/01 ,  A61K38/43 ,  A61K36/00 ,  A61P35/00 ,  A61M1/00

CPC classification number: A61M31/00 ,  A61K9/0024 ,  A61K9/0036 ,  A61K9/204 ,  A61K9/205 ,  A61K31/01 ,  A61K31/05 ,  A61K31/121 ,  A61K31/366 ,  A61K31/404 ,  A61K31/497

Abstract: The presently-disclosed subject matter provides compositions and methods for treating a cancer by providing a composition comprising a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and a chemotherapeutic agent. Further, provided is a device for uterine cervical insertion for local delivery.

Abstract translation: 目前公开的主题提供了通过提供包含有效量的植物化学试剂，植物化学试剂或植物化学试剂和化学治疗剂的组合的生物相容性聚合物基质的组合物来治疗癌症的组合物和方法。 此外，提供了用于子宫颈插入用于局部递送的装置。

公开(公告)号：US08858995B2

公开(公告)日：2014-10-14

申请号：US13429601

申请日：2012-03-26

Applicant: Ramesh C. Gupta ,  Manicka V. Vadhanam ,  Farrukh Aqil

Inventor： Ramesh C. Gupta ,  Manicka V. Vadhanam ,  Farrukh Aqil

IPC: A61K9/26 ,  A61K47/40 ,  A61K45/06 ,  A61K31/121 ,  A61K9/00 ,  A61K36/82 ,  A61K31/05 ,  A61K31/366 ,  A61K36/235 ,  A61K47/10 ,  A61K47/34 ,  A61K31/404 ,  A61K31/01 ,  A61K36/9066 ,  A61K31/497

CPC classification number: A61K9/0036 ,  A61K9/0024 ,  A61K31/01 ,  A61K31/05 ,  A61K31/121 ,  A61K31/366 ,  A61K31/404 ,  A61K31/497 ,  A61K36/235 ,  A61K36/82 ,  A61K36/9066 ,  A61K45/06 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K2300/00

Abstract: Compositions are provided that comprises a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and one or more additional therapeutic agents. Methods of treating a cancer using the compositions are further provided.

Abstract translation: 提供了组合物，其包含结合有效量的植物化学试剂，植物化学试剂或植物化学试剂和一种或多种另外的治疗剂的组合的生物相容性聚合物基质。 进一步提供使用该组合物治疗癌症的方法。

公开(公告)号：US08378104B2

公开(公告)日：2013-02-19

申请号：US13025281

申请日：2011-02-11

Applicant: Keith R. Hornberger ,  Dan M. Berger ,  Xin Chen ,  Andrew P. Crew ,  Hanqing Dong ,  Andrew Kleinberg ,  An-Hu Li ,  Lifu Ma ,  Mark J. Mulvihill ,  Bijoy Panicker ,  Kam W. Siu ,  Arno G. Steinig ,  James G. Tarrant ,  Jing Wang ,  Qinghua Weng ,  Rajaram Sangem ,  Ramesh C. Gupta

Inventor： Keith R. Hornberger ,  Dan M. Berger ,  Xin Chen ,  Andrew P. Crew ,  Hanqing Dong ,  Andrew Kleinberg ,  An-Hu Li ,  Lifu Ma ,  Mark J. Mulvihill ,  Bijoy Panicker ,  Kam W. Siu ,  Arno G. Steinig ,  James G. Tarrant ,  Jing Wang ,  Qinghua Weng ,  Rajaram Sangem ,  Ramesh C. Gupta

IPC: C07D471/02

CPC classification number: C07D491/048

Abstract: Compounds of Formula 1, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.

Abstract translation: 式1的化合物，如下文所定义：其药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括治疗癌症，例如至少部分由TAK1驱动的肿瘤，或适合于 TAK1抑制剂有效。 本发明并不限于本发明。

公开(公告)号：US20120329826A1

公开(公告)日：2012-12-27

申请号：US13581619

申请日：2011-03-03

Applicant: An-Hu Li ,  Ramesh C. Gupta ,  Mark J. Mulvihill ,  Anand Narain Rai ,  Jing Wang

Inventor： An-Hu Li ,  Ramesh C. Gupta ,  Mark J. Mulvihill ,  Anand Narain Rai ,  Jing Wang

IPC: C07D471/02 ,  A61P35/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by RON and/or MET.

Abstract translation: 式I的化合物，如下文所示和本文定义：药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括至少部分地由RON和/或MET介导的癌症。

公开(公告)号：US20120231079A1

公开(公告)日：2012-09-13

申请号：US13429601

申请日：2012-03-26

Applicant: Ramesh C. Gupta ,  Manicka V. Vadhanam ,  Farrukh Aqil

Inventor： Ramesh C. Gupta ,  Manicka V. Vadhanam ,  Farrukh Aqil

IPC: A61K31/12 ,  A61K31/404 ,  A61P35/00 ,  A61K31/497 ,  A61K31/01 ,  A61K9/00 ,  A61K31/05 ,  A61K31/7048

CPC classification number: A61K9/0036 ,  A61K9/0024 ,  A61K31/01 ,  A61K31/05 ,  A61K31/121 ,  A61K31/366 ,  A61K31/404 ,  A61K31/497 ,  A61K36/235 ,  A61K36/82 ,  A61K36/9066 ,  A61K45/06 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K2300/00

Abstract: Compositions are provided that comprises a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and one or more additional therapeutic agents. Methods of treating a cancer using the compositions are further provided.

Abstract translation: 提供了组合物，其包含结合有效量的植物化学试剂，植物化学试剂或植物化学试剂和一种或多种另外的治疗剂的组合的生物相容性聚合物基质。 进一步提供使用该组合物治疗癌症的方法。

公开(公告)号：US20110136764A1

公开(公告)日：2011-06-09

申请号：US12791047

申请日：2010-06-01

Applicant: Rama Devi APPARI ,  Xin CHEN ,  Ramesh Chllukuri ,  Andrew P. CREW ,  Hanqing DONG ,  Caterina FERRARO ,  Kenneth FOREMAN ,  Ramesh C. GUPTA ,  An-Hu LI ,  Dan SHERMAN ,  Kathryn M. STOLZ ,  Brian VOLK ,  Robert ZAHLER

Inventor： Rama Devi APPARI ,  Xin CHEN ,  Ramesh Chllukuri ,  Andrew P. CREW ,  Hanqing DONG ,  Caterina FERRARO ,  Kenneth FOREMAN ,  Ramesh C. GUPTA ,  An-Hu LI ,  Dan SHERMAN ,  Kathryn M. STOLZ ,  Brian VOLK ,  Robert ZAHLER

IPC: A61K31/675 ,  C07F9/6558 ,  C07F9/6561 ,  C07F9/6564 ,  A61P35/00

CPC classification number: C07F9/65583 ,  A61K31/497 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07F9/6512 ,  C07F9/6544

Abstract: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

Abstract translation: 合成，中间体，制剂及其治疗方法，包括至少部分由FAK介导的癌症的式1化合物，如下文所定义。

公开(公告)号：US06258976B1

公开(公告)日：2001-07-10

申请号：US09272102

申请日：1999-03-19

Applicant: Francis Johnson ,  Ramesh C. Gupta

Inventor： Francis Johnson ,  Ramesh C. Gupta

IPC: C07C26100

CPC classification number: C07C279/24 ,  C07C209/48 ,  C07C209/62 ,  C07C269/06 ,  C07C335/08 ,  C07C335/26 ,  C07C381/06 ,  Y02P20/55 ,  C07C211/14 ,  C07C271/20

Abstract: Disclosed are processes for the preparation of compounds of the formula (I): H2N—(CH2)n—A—(CH2)m—NH2, or (II): H2N—(CH2)n—NH—C(═NR1)—NH—(CH2)m—NH2, wherein n and m are each independently an integer from 2 to 8; A is selected from the group consisting of —NR1—, —NR1—(CH2)r—NR1— and —NR1—(CH2)r—NR1—(CH2)z—NR1—, wherein r and z are an integer ranging from 2 to 8; and R1 is hydrogen or a protecting group having a carbonyl group.

Abstract translation: 公开了制备式（I）化合物的方法：H 2 N-（CH 2）nA-（CH 2）m -NH 2或（II）：H 2 N-（CH 2）n -NH-C（= NR 1）-NH - （CH 2）m -NH 2，其中n和m各自独立地为2至8的整数; A选自-NR1-，-NR1-（CH2）r-NR1-和-NR1-（CH2）r-NR1-（CH2）z-NR1-，其中r和z是从 2至8; 并且R 1是氢或具有羰基的保护基。

公开(公告)号：US20160264593A1

公开(公告)日：2016-09-15

申请号：US15036760

申请日：2014-11-14

Applicant: John S. Kovach ,  Francis Johnson ,  Ramakrishna Samudrala ,  Ramesh C. Gupta

Inventor： John S. Kovach ,  Francis Johnson ,  Ramakrishna Samudrala ,  Ramesh C. Gupta

IPC: C07D493/08 ,  C07F9/6561

CPC classification number: C07D493/08 ,  A61K31/4178 ,  A61K31/4433 ,  A61K31/496 ,  A61K45/06 ,  C07F9/6561 ,  A61K2300/00

Abstract: The present invention provides a method for in vivo delivery of endothal to a target cell in a subject, the method comprising administering to the subject a compound having the structure: Formula (I).

公开(公告)号：US08987481B1

公开(公告)日：2015-03-24

申请号：US14187245

申请日：2014-02-22

Applicant: Ramesh C Gupta

Inventor： Ramesh C Gupta

IPC: C07D311/76 ,  A23L1/275

CPC classification number: C07D311/76 ,  A23L5/43 ,  C07D311/62

Abstract: This invention describes a simple, rapid and cost-effective method to isolate bulk quantities of relatively pure and enriched anthocyanidins and other plant bioactives. The method is based on the principle of solubility. Some bioactives (anthocyanidins) were extracted in an aqueous solvent, transferred to a non-aqueous solvent and finally insolubilized by adding a miscible solvent in which the bioactive was insoluble. Thus, anthocyanidins were isolated from anthocyanin-enriched berries or non-enriched, dark-colored fruits, vegetables and grains by extraction of anthocyanins, acid hydrolysis, and extraction of the resulting anthocyanidins, followed by their insolubilization (precipitation). Some bioactives (hydrophobic and hydrophilic) were extracted in a solvent with high solubility and then directly insolubilized by adding a miscible solvent in which the bioactive was insoluble, for example, withaferin A from enriched Withania somnifera and punicalagins from enriched punica extract.

Abstract translation: 本发明描述了分离大量相对纯的和富集的花青素和其它植物生物活性物的简单，快速和成本有效的方法。 该方法是基于溶解度的原理。 一些生物活性物质（花色素苷）在水性溶剂中提取，转移到非水溶剂中，最后通过加入其中生物活性不溶性的混溶溶剂而不溶解。 因此，通过提取花青素，酸水解和提取所得花青素，然后使其不溶（沉淀），从花青素浓缩的浆果或非浓缩的深色水果，蔬菜和谷物中分离出花青素。 一些生物活性物质（疏水性和亲水性）在高溶解度的溶剂中提取，然后通过加入其中生物活性不溶性的可混溶溶剂直接不溶，例如来自富集的有色金属藻的嗜铬蛋白A和来自浓缩的竹提取物的刺梧桐木。