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1.发明申请IMMUNOGLOBULIN CLEAVAGE FRAGMENT VACCINE COMPOSITIONS 审中-公开免疫球蛋白CLEAVAGE FRAGMENT VACCINE COMPOSITIONS公开(公告)号：US20120269834A1
公开(公告)日：2012-10-25
申请号：US13318168
申请日：2010-11-19
申请人： Robert Jordan , David M. Knight , Randall Brezski
发明人： Robert Jordan , David M. Knight , Randall Brezski
IPC分类号： A61K39/00 , A61P9/00 , A61P9/04 , A61P29/00 , A61P35/00 , A61P31/04 , A61K39/385 , A61P33/00
CPC分类号： A61K39/00 , A61K39/0005 , A61K39/0008 , A61K2039/505 , A61K2039/55 , A61K2039/58 , A61K2039/585 , C07K16/065 , C07K16/18 , C07K16/42 , C07K2317/50 , C07K2317/53 , C07K2317/734
摘要： The invention relates to methods and reagents for the preparation and use of a therapeutic immunospecific for IgG breakdown products retaining antigen binding but having lost effector functions. The reagents of the invention may be used as immunogens for the purpose of prophylactic or therapeutic vaccination of a human subject.
摘要翻译： 本发明涉及用于制备和使用保护抗原结合但具有失去效应子功能的IgG分解产物的治疗免疫特异性的方法和试剂。 本发明的试剂可以作为免疫原用于预防性或治疗性接种人类受试者的目的。
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公开(公告)号：US08871204B2
公开(公告)日：2014-10-28
申请号：US13555334
申请日：2012-07-23
申请人： Randall Brezski , Robert Jordan , William Strohl
发明人： Randall Brezski , Robert Jordan , William Strohl
CPC分类号： C07K16/30 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to modified Fc-containing molecules including modified antibodies characterized by increased resistance to host and pathogen-derived proteases, ability to interact with FcγR receptors except with FcγRI, and lack of induction of IL-10 secretion by macrophages, and methods of using and making them.
摘要翻译： 本发明涉及修饰的含Fc分子，包括特征在于对宿主和病原体衍生的蛋白酶的抗性增加，与FcγRI之外的FcγR受体相互作用的能力和由巨噬细胞诱导IL-10分泌的方法， 使用和使他们。
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公开(公告)号：US20130011386A1
公开(公告)日：2013-01-10
申请号：US13555334
申请日：2012-07-23
申请人： Randall Brezski , Robert Jordan , William Strohl
发明人： Randall Brezski , Robert Jordan , William Strohl
IPC分类号： C07K16/00 , A61P31/00 , A61P35/00 , C07K16/46 , A61K39/395
CPC分类号： C07K16/30 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to modified Fc-containing molecules including modified antibodies characterized by increased resistance to host and pathogen-derived proteases, ability to interact with FcγR receptors except with FcγRI, and lack of induction of IL-10 secretion by macrophages, and methods of using and making them.
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4.发明申请IMMUNOGLOBULIN CLEAVAGE FRAGMENTS AS DISEASE INDICATORS AND COMPOSITIONS FOR DETECTING AND BINDING SUCH 有权免疫球蛋白作为疾病指示剂的清洁片和组合物用于检测和结合公开(公告)号：US20110076264A1
公开(公告)日：2011-03-31
申请号：US12950240
申请日：2010-11-19
申请人： Robert Jordan , David Knight , Randall Brezski
发明人： Robert Jordan , David Knight , Randall Brezski
IPC分类号： A61K39/395 , C07K16/42 , C07K7/08 , C07K14/00 , C07K14/765 , A01K67/00 , A61P19/02 , A61P31/04 , A61P33/00 , A61P9/00 , A61P35/00 , A61K39/00
CPC分类号： C07K16/42 , A61K2039/505 , A61K2039/507 , C07K7/08 , C07K16/065 , C07K16/2848 , C07K16/36 , C07K2317/24 , C07K2317/34 , C07K2317/50 , C07K2317/732 , C07K2317/734 , G01N33/6854 , G01N33/6857
摘要： The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.
摘要翻译： 本发明涉及抗体组合物和该组合物用于检测与精制蛋白酶相关的疾病过程的用途。 试剂用于评估作为这种蛋白水解切割结果的IgG分解产物。 本发明还涉及用于IgG蛋白酶切割产物的治疗免疫特异性用于恢复经受蛋白酶切割的抗体组合物的效应子功能的用途。
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5.发明授权Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such 有权免疫球蛋白裂解片段作为疾病指标和用于检测和结合的组合物公开(公告)号：US08501907B2
公开(公告)日：2013-08-06
申请号：US12950240
申请日：2010-11-19
申请人： Robert Jordan , David Knight , Randall Brezski , Mary Ryan , Diane Petrone
发明人： Robert Jordan , David Knight , Randall Brezski , Mary Ryan , Diane Petrone
CPC分类号： C07K16/42 , A61K2039/505 , A61K2039/507 , C07K7/08 , C07K16/065 , C07K16/2848 , C07K16/36 , C07K2317/24 , C07K2317/34 , C07K2317/50 , C07K2317/732 , C07K2317/734 , G01N33/6854 , G01N33/6857
摘要： The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.
摘要翻译： 本发明涉及抗体组合物和该组合物用于检测与精制蛋白酶相关的疾病过程的用途。 试剂用于评估作为这种蛋白水解切割结果的IgG分解产物。 本发明还涉及用于IgG蛋白酶切割产物的治疗免疫特异性用于恢复经受蛋白酶切割的抗体组合物的效应子功能的用途。
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