-
公开(公告)号：US09150649B2
公开(公告)日：2015-10-06
申请号：US12574466
申请日：2009-10-06
CPC分类号： A61K47/48215 , A61K31/5386 , A61K47/54 , A61K47/60 , A61K47/6803 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6863 , A61K47/6889 , A61K47/6891 , C07D498/18 , C07K16/2803 , C07K16/30 , C07K2317/24 , Y02A50/491
摘要： Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment. A method for preparing maytansinoids bearing a thioether moiety and a reactive group which allows the maytansinoid to be linked to a cell-binding agent in essentially a single step is also provided.
摘要翻译： 用于将药物与细胞结合剂结合的接头通过并入聚乙二醇间隔物而被修饰成亲水接头。 细胞结合剂 - 药物偶联物的效力或功效令人惊奇地增加了多种癌细胞类型的几倍，包括在细胞表面上表达低数目抗原的那些或对治疗有抗性的癌细胞。 还提供了一种制备具有硫醚部分的美登木素生物碱和允许美登木素生物碱在基本上单一步骤中与细胞结合剂连接的反应性基团的方法。
-
公开(公告)号：US08435528B2
公开(公告)日：2013-05-07
申请号：US11778451
申请日：2007-07-16
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K31/5365 , A61K47/6803 , A61K2039/505 , C07D498/16
摘要： New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
-
公开(公告)号：US08163736B2
公开(公告)日：2012-04-24
申请号：US12174195
申请日：2008-07-16
申请人： Laurence Gauzy , Herve Bouchard , Ravi V. J. Chari , Alain Commercon , Robert Zhao , Yonghong Deng , Wei Li
发明人： Laurence Gauzy , Herve Bouchard , Ravi V. J. Chari , Alain Commercon , Robert Zhao , Yonghong Deng , Wei Li
IPC分类号： C07D519/00 , C07D487/00 , A61K31/5517
CPC分类号： C07D487/04
摘要： The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.
摘要翻译： 本发明涉及新的茅屋霉素衍生物，其制备方法及其治疗用途。
-
公开(公告)号：US08093358B2
公开(公告)日：2012-01-10
申请号：US11949351
申请日：2007-12-03
申请人： Walter Blättler , Ravi V. J. Chari
发明人： Walter Blättler , Ravi V. J. Chari
IPC分类号： C07K16/00
摘要： The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB receptor antibody-maytansinoid conjugates.
-
公开(公告)号：US20100092495A1
公开(公告)日：2010-04-15
申请号：US12574430
申请日：2009-10-06
申请人： Ravi V. J. CHARI
发明人： Ravi V. J. CHARI
IPC分类号： A61K39/395 , C07K16/18 , A61P35/04
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K47/6851 , C07K16/30 , C07K2317/73
摘要： The present invention relates to the use of about 2 to about 8 drug molecules, for example, maytansinoid, per cell binding agent, such as an antibody, and maximal efficacy as compared to a drug load of lesser or higher number of drugs linked to such a cell binding agent.
摘要翻译： 本发明涉及使用约2至约8种药物分子，例如美登木素生物碱，每种细胞结合剂，例如抗体，以及与药物负载量相关的较小或更多数量的药物相比，具有最大功效 细胞结合剂。
-
公开(公告)号：US07667054B2
公开(公告)日：2010-02-23
申请号：US11295294
申请日：2005-12-06
IPC分类号： C07D305/00
CPC分类号： C07D493/06
摘要： The invention relates to novel cytotoxic agents comprising taxanes and their therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent.
摘要翻译： 本发明涉及包含紫杉烷的新型细胞毒性剂及其治疗用途，其通过将紫杉烷与细胞结合剂化学连接而以目标方式将紫杉烷递送至特定细胞群。
-
7.发明授权Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents 有权使用免疫缀合物和化学治疗剂治疗癌症的组合物和方法公开(公告)号：US07601354B2
公开(公告)日：2009-10-13
申请号：US11453008
申请日：2006-06-15
申请人： Ravi V. J. Chari
发明人： Ravi V. J. Chari
IPC分类号： A61K39/00
CPC分类号： A61K31/337 , A61K47/6803 , A61K47/6849 , Y02A50/423 , Y02A50/491 , A61K2300/00
摘要： The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.
摘要翻译： 本发明基于这样的发现，即至少一种免疫缀合物和至少一种化学治疗剂的施用提供了对于癌症的意想不到的优异治疗。 本发明涉及包含至少一种免疫缀合物和至少一种化学治疗剂的组合物以及使用至少一种免疫缀合物和至少一种化学治疗剂治疗癌症的方法。 本发明还提供了通过施用治疗有效量的至少一种化学治疗剂和至少一种免疫缀合物来调节所选细胞群体如癌细胞的生长的方法。
-
公开(公告)号：US07585857B2
公开(公告)日：2009-09-08
申请号：US11844183
申请日：2007-08-23
IPC分类号： A61K31/30 , A61K31/337
CPC分类号： C07D305/14 , A61K31/337 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6881 , A61K2039/505 , C07K16/2863 , C07K16/32 , Y02A50/423 , Y02A50/491
摘要： A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
-
9.发明授权公开(公告)号：US07495114B2
公开(公告)日：2009-02-24
申请号：US10926192
申请日：2004-08-26
申请人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
发明人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
IPC分类号： C07D305/00
CPC分类号： C07D407/12 , A61K31/337 , C07D305/14 , C07D407/14 , C07D409/12 , Y02A50/423 , Y02A50/491
摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.
摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒量的一种或多种通过连接基团与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 包括。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。
-
公开(公告)号：US07476669B2
公开(公告)日：2009-01-13
申请号：US11785482
申请日：2007-04-18
IPC分类号： A61K38/22 , A61K39/395 , C07D413/02
CPC分类号： C07D305/14 , A61K31/337 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6881 , A61K2039/505 , C07K16/2863 , C07K16/32 , Y02A50/423 , Y02A50/491
摘要： A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
-
-
-
-
-
-
-
-
-
搜索结果
74 条记录 (耗时 0.045 秒)
