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公开(公告)号：USD471971S1
公开(公告)日：2003-03-18
申请号：US29148528
申请日：2001-09-20
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公开(公告)号：US09034879B2
公开(公告)日：2015-05-19
申请号：US14343861
申请日：2012-09-14
申请人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel
发明人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel
IPC分类号： A61K31/497 , C07D417/04 , C07D413/04 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/497 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D417/04
摘要： The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供式I的吡啶并恶二唑/噻二唑衍生物，其中A为N或CR 4a; 和（ii）或（iii）其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20140228376A1
公开(公告)日：2014-08-14
申请号：US14343861
申请日：2012-09-14
申请人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel
发明人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel
IPC分类号： A61K31/497 , C07D417/04 , A61K45/06 , C07D413/04 , A61K31/4439
CPC分类号： A61K31/497 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D417/04
摘要： The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供式I的吡啶并恶二唑/噻二唑衍生物，其中A为N或CR 4a; 和（ii）或（iii）其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20090233631A1
公开(公告)日：2009-09-17
申请号：US12382320
申请日：2009-03-13
申请人： Alvin Butler, SR. , Rebecca Butler
发明人： Alvin Butler, SR. , Rebecca Butler
IPC分类号： H04W4/00
摘要： A process and system used for reporting and processing incidents of aggressive, dangerous, and discourteous drivers using Short Message Service (SMS) data, also known as “text messaging” using key words or characters. A hand held electronic device is used to send a text message location reporting emergency or non-emergency information to a central processing unit. By establishing a process and system that utilizes mobile hand held electronic devices or cell phones to report emergency and non-emergency information through text messaging and downloading that information to the central processing unit, this data is then put through a filtration process to allow the most serious road violators and those needing help to be easily retrieved. The information is then transmitted to a subscriber via text message and/or email for corrective action or for dispatching emergency help.
摘要翻译： 用于使用短消息服务（SMS）数据（也称为“文本消息”）使用关键字或字符来报告和处理侵略性，危险和不诚实的司机的事件的过程和系统。 手持式电子设备用于向中央处理单元发送报告紧急或非紧急信息的文本消息位置。 通过建立一个使用移动手持电子设备或手机通过短信来报告紧急和非紧急信息并将该信息下载到中央处理单元的过程和系统，然后将该数据通过过滤处理以允许最多 严重的道路违法者和需要帮助的人容易检索。 然后通过文本消息和/或电子邮件将信息发送给用户以进行纠正措施或发送紧急帮助。
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公开(公告)号：US20150376183A1
公开(公告)日：2015-12-31
申请号：US14767500
申请日：2014-02-11
IPC分类号： C07D471/04 , A61K31/4375
CPC分类号： C07D471/04 , A61K31/4375
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供活化IP受体的杂环衍生物。 激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US08318935B2
公开(公告)日：2012-11-27
申请号：US12451152
申请日：2008-05-05
申请人： Robin Alec Fairhurst , Rebecca Butler , Paul Oakley , Stephen Paul Collingwood , Nichola Smith , Emily Stanley , Maria Ines Rodriguez Perez
发明人： Robin Alec Fairhurst , Rebecca Butler , Paul Oakley , Stephen Paul Collingwood , Nichola Smith , Emily Stanley , Maria Ines Rodriguez Perez
IPC分类号： C07D401/14 , A61K31/497 , A61P11/06
CPC分类号： C07D401/14
摘要： A compound of formula (I), or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 and R5a are as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration.
摘要翻译： 其中M1，M2，L1，L2，W1，W2，X1，X2，Y1，Y2，A，R5和R5a为式（I）化合物或其互变异构体或立体异构体或溶剂合物或其药学上可接受的盐 如本文所定义的用于治疗可通过阻断上皮钠通道治疗的病症，特别是有益于粘膜水合的病症。
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公开(公告)号：USD471624S1
公开(公告)日：2003-03-11
申请号：US29148496
申请日：2001-09-20
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