专利检索 ap:("Kamlesh Jagdis Bala" OR "Rebecca Butler" OR "Stephen Paul Collingwood" OR "Edward Charles Hall" OR "Lee Edwards" OR "Darren Mark Legrand" OR "Katrin Spiegel") AND inv:"Edward Charles Hall" 第 1 页

1.

发明授权
Heterocyclic compounds for the treatment of CF 有权
标题翻译：用于治疗CF的杂环化合物

公开(公告)号：US09034879B2

公开(公告)日：2015-05-19

申请号：US14343861

申请日：2012-09-14

申请人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel

发明人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel

IPC分类号： A61K31/497 , C07D417/04 , C07D413/04 , A61K31/4439 , A61K45/06

CPC分类号： A61K31/497 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D417/04

摘要： The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

摘要翻译： 本发明提供式I的吡啶并恶二唑/噻二唑衍生物，其中A为N或CR 4a; 和（ii）或（iii）其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。还包括包含这些衍生物的药物组合物。

2.

发明申请
Heterocyclic Compounds for the Treatment of CF 有权
标题翻译：用于治疗CF的杂环化合物

公开(公告)号：US20140228376A1

公开(公告)日：2014-08-14

申请号：US14343861

申请日：2012-09-14

申请人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel

发明人： Kamlesh Jagdis Bala , Rebecca Butler , Stephen Paul Collingwood , Edward Charles Hall , Lee Edwards , Darren Mark Legrand , Katrin Spiegel

IPC分类号： A61K31/497 , C07D417/04 , A61K45/06 , C07D413/04 , A61K31/4439

CPC分类号： A61K31/497 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D417/04

摘要： The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

摘要翻译： 本发明提供式I的吡啶并恶二唑/噻二唑衍生物，其中A为N或CR 4a; 和（ii）或（iii）其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。还包括包含这些衍生物的药物组合物。