公开(公告)号：US20050169852A1

公开(公告)日：2005-08-04

申请号：US11037560

申请日：2005-01-18

申请人： Rebecca Roberge ,  Andrew Wong

发明人： Rebecca Roberge ,  Andrew Wong

IPC分类号： A61K8/34 ,  A61K8/41 ,  A61K8/49 ,  A61Q11/00 ,  A61K7/16

CPC分类号： A61K8/345 ,  A61K8/416 ,  A61K8/4926 ,  A61Q11/00

摘要： Disclosed are oral care compositions, including therapeutic rinses, especially mouthrinses and methods of use to provide significantly enhanced antimicrobial activity, thereby reducing oral bacteria and promoting overall oral health. The present compositions are formulated to deliver increased bioavailable levels of cationic antimicrobials, particularly quaternary ammonium compounds such as cetylpyridinium chloride (CPC) and are useful for preventing and treating diseases or conditions of the oral cavity including dental plaque, caries, gingivitis, periodontal disease and breath malodor. The present compositions are formulated to be essentially free of anionic, nonionic or amphoteric surfactants, which have been found to have a negative effect on bioavailability of the quaternary ammonium compounds and thus, their antimicrobial efficacy.

摘要翻译： 公开了口腔护理组合物，包括治疗性漂洗剂，特别是口服液和用于提供显着增强的抗微生物活性的方法，从而减少口腔细菌并促进总体口腔健康。 本发明的组合物被配制成递送增加的生物可利用水平的阳离子抗微生物剂，特别是季铵化合物如氯化十六烷基吡啶（CPC），并且可用于预防和治疗口腔疾病或病症，包括牙菌斑，龋齿，牙龈炎，牙周病和 呼吸恶臭 将本发明的组合物配制成基本上不含阴离子，非离子或两性表面活性剂，这些表面活性剂已被发现对季铵化合物的生物利用度具有负面影响，因此具有其抗微生物效能。