公开(公告)号：US08846383B2

公开(公告)日：2014-09-30

申请号：US10521387

申请日：2003-06-21

申请人： Reiner Luttmann ,  Wilfried Kappel ,  Toralf Gliem ,  Mohammad Saeed Ajam ,  Lars Boettcher ,  Bernd-Ulrich Wilhelm ,  Wolfgang Rietschel

发明人： Reiner Luttmann ,  Wilfried Kappel ,  Toralf Gliem ,  Mohammad Saeed Ajam ,  Lars Boettcher ,  Bernd-Ulrich Wilhelm ,  Wolfgang Rietschel

IPC分类号： C12M1/12 ,  B01D61/14 ,  B01D61/22 ,  C12P21/00 ,  C12M1/00 ,  C12M1/34

CPC分类号： B01D61/147 ,  B01D61/142 ,  B01D61/145 ,  B01D61/22 ,  C12M29/04 ,  C12M29/18 ,  C12M41/36 ,  C12P21/00

摘要： Disclosed are a method and a device for the biotechnological production of valuable products, in which a medium is fed to a bioreactor and is subjected to a fermentation process, the valuable product is gathered as a filtered permeate and/or concentrated retentate via a cross-flow filtration system that is mounted downstream thereof, and residues are once again fed to the bioreactor until being gathered as a retentate. Other materials can be fed to the bioreactor in a controlled manner in addition to the medium while the concentrated retentate and permeate can be gathered in a controlled manner. The fermentation process and the filtration process are regulated in a synchronized manner in an integrated system via a digital control unit.

摘要翻译： 公开了一种用于生物技术生产有价值产品的方法和装置，其中将培养基进料到生物反应器并进行发酵过程，有价值的产物通过交联物质作为过滤的渗透物和/或浓缩滞留物收集， 流动过滤系统，其安装在其下游，并且残余物再次进料至生物反应器，直到作为滞留物收集。 除了介质之外，其它材料可以以受控的方式进料到生物反应器中，同时可以以受控的方式收集浓缩的滞留物和渗透物。 发酵过程和过滤过程通过数字控制单元以同步方式在集成系统中调节。

公开(公告)号：US20060014239A1

公开(公告)日：2006-01-19

申请号：US10521387

申请日：2003-06-21

申请人： Reiner Luttmann ,  Wilfried Kappel ,  Toralf Gliem ,  Mohammad Ajam ,  Lars Boettcher ,  Bernd-Ulrich Wilhelm ,  Wolfgang Rietschel

发明人： Reiner Luttmann ,  Wilfried Kappel ,  Toralf Gliem ,  Mohammad Ajam ,  Lars Boettcher ,  Bernd-Ulrich Wilhelm ,  Wolfgang Rietschel

IPC分类号： C12P1/00

CPC分类号： B01D61/147 ,  B01D61/142 ,  B01D61/145 ,  B01D61/22 ,  C12M29/04 ,  C12M29/18 ,  C12M41/36 ,  C12P21/00

摘要： Disclosed are a method and a device for the biotechnological production of valuable products, in which a medium is fed to a bioreactor and is subjected to a fermentation process, the valuable product is gathered as a filtered permeate and/or concentrated retentate via a cross-flow filtration system that is mounted downstream thereof, and residues are once again fed to the bioreactor until being gathered as a retentate. Other materials can be fed to the bioreactor in a controlled manner in addition to the medium while the concentrated retentate and permeate can be gathered in a controlled manner. The fermentation process and the filtration process are regulated in a synchronized manner in an integrated system via a digital control unit.

摘要翻译： 公开了一种用于生物技术生产有价值产品的方法和装置，其中将培养基进料到生物反应器并进行发酵过程，有价值的产物通过交联物质作为过滤的渗透物和/或浓缩滞留物收集， 流动过滤系统，其安装在其下游，并且残余物再次进料至生物反应器，直到作为滞留物收集。 除了介质之外，其它材料可以以受控的方式进料到生物反应器中，同时可以以受控的方式收集浓缩的滞留物和渗透物。 发酵过程和过滤过程通过数字控制单元以同步方式在集成系统中调节。