公开(公告)号：US20070149573A1

公开(公告)日：2007-06-28

申请号：US11318236

申请日：2005-12-23

申请人： Lidija Savanovic ,  Dejan Mandic ,  Renata Casar

发明人： Lidija Savanovic ,  Dejan Mandic ,  Renata Casar

IPC分类号： A61K31/4439 ,  C07D403/02

CPC分类号： C07D401/12

摘要： The present invention discloses a process for preparing a magnesium salt of S-omeprazole. The S-omeprazole salt preferably has a water content below about 4.8% by weight, a magnesium content of about 3.4-4.0% by weight, calculated on the weight of anhydrous, solvent free S-omeprazole magnesium, and has an optical purity of at least about 85% entantiomeric excess (“e.e.”). In addition, the present invention provides a magnesium salt of S-omeprazole which is substantially free of neutral omeprazole, meaning that the product contains less than about 3% by weight of a-sum of neutral S-omeprazole and neutral omeprazole. Moreover, the S-omeprazole magnesium according to the invention preferably has assay of related substances and degradation products of less than about 0.1 % by weight as determined by high performance liquid chromatography (HPLC).

摘要翻译： 本发明公开了一种制备S-奥美拉唑镁盐的方法。 S-奥美拉唑盐的水含量优选低于约4.8重量％，镁含量为约3.4-4.0重量％，以无水，无溶剂的S-奥美拉唑镁的重量计，其光学纯度为 至少约85％的对映异构体过量（“ee”）。 此外，本发明提供了基本上不含中性奥美拉唑的S-奥美拉唑镁盐，意味着该产品含有小于约3重量％的中和S-奥美拉唑和中性奥美拉唑的总和。 此外，根据本发明的S-奥美拉唑镁优选具有通过高效液相色谱（HPLC）测定的相关物质和降解产物的测定值小于约0.1重量％。

公开(公告)号：US20080045602A1

公开(公告)日：2008-02-21

申请号：US11793850

申请日：2005-12-22

申请人： Renata Casar

发明人： Renata Casar

IPC分类号： C07C215/54 ,  A61K31/10 ,  C07C317/14 ,  A61K31/135

CPC分类号： C07C309/65 ,  C07C213/02 ,  C07C309/73 ,  C07C215/54

摘要： A new process for preparation of 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine from 3,4-dihydro-6-methyl-4-phenyl-2-benzopyran-2-one is characterized by intermediates such as 3-(2-hydroxy-5-methylphenyl)-3-phenylpropanol and its sulphonated derivatives and amination in presence of sodium iodide

摘要翻译： 从3,4-二氢-6-甲基-4-苯基-2-苯并吡喃-2-酮制备3-（2-羟基-5-甲基苯基）-N，N-二异丙基-3-苯基丙胺的新方法是 其特征在于中间体如3-（2-羟基-5-甲基苯基）-3-苯基丙醇及其磺化衍生物，并在碘化钠存在下胺化