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    Antiviral oligonucleotides targeting HIV
    2.
    发明申请
    Antiviral oligonucleotides targeting HIV 审中-公开
    靶向HIV的抗病毒寡核苷酸

    公开(公告)号：US20040171568A1

    公开(公告)日：2004-09-02

    申请号：US10661099

    申请日：2003-09-12

    申请人： Replicor, Inc.

    发明人： Andrew Vaillant ,  Jean-Marc Juteau

    IPC分类号： A61K048/00

    CPC分类号： C12N15/115 ,  A61K31/7088 ,  A61K38/00 ,  A61K45/06 ,  C12N15/11 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  A61K2300/00 ,  C12N2310/3521

    摘要： Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.

    摘要翻译： 描述了具有抗病毒活性的随机序列寡核苷酸及其作为抗病毒剂的用途。 在许多情况下，寡核苷酸长度大于40个核苷酸。 还描述了用于预防或治疗人或动物中的病毒感染的方法，以及用于预防人类或动物中由佐剂病毒引起的癌症的方法。 所述方法通常涉及向需要这种治疗的人或动物施用药理学上可接受的治疗有效量的至少不受序列互补作用模式作用的寡核苷酸。

    Antiviral oligonucleotides targeting HBV
    6.
    发明申请
    Antiviral oligonucleotides targeting HBV 审中-公开
    针对HBV的抗病毒寡核苷酸

    公开(公告)号：US20040162253A1

    公开(公告)日：2004-08-19

    申请号：US10661088

    申请日：2003-09-12

    申请人： Replicor, Inc.

    发明人： Andrew Vaillant ,  Jean-Marc Juteau

    IPC分类号： A61K048/00

    CPC分类号： C12N15/115 ,  A61K31/7088 ,  A61K38/00 ,  A61K45/06 ,  C12N15/11 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  A61K2300/00 ,  C12N2310/3521

    摘要： Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.

    摘要翻译： 描述了具有抗病毒活性的随机序列寡核苷酸及其作为抗病毒剂的用途。 在许多情况下，寡核苷酸长度大于40个核苷酸。 还描述了用于预防或治疗人或动物中的病毒感染的方法，以及用于预防人类或动物中由佐剂病毒引起的癌症的方法。 所述方法通常涉及向需要这种治疗的人或动物施用药理学上可接受的治疗有效量的至少不受序列互补作用模式作用的寡核苷酸。

    Oligonucleotide chelate complexes
    8.
    发明授权
    Oligonucleotide chelate complexes 有权
    寡核苷酸螯合物

    公开(公告)号：US08716259B2

    公开(公告)日：2014-05-06

    申请号：US13905318

    申请日：2013-05-30

    申请人： Replicor Inc.

    发明人： Andrew Vaillant ,  Michel Bazinet

    IPC分类号： A61K31/712 ,  A61K31/7125 ,  A61K31/7115 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： A61K31/7088 ,  A61K9/0019 ,  A61K31/713 ,  A61K47/02

    摘要： The present disclosure describes the broadly active chelation of diverse divalent 2+ metal cations by any oligonucleotide (ON), regardless of size or modification. This chelation effect is specific to cations which are divalent (or of higher valency) and results in the formation of oligonucleotide chelate complexes which do not behave like salts. It is described herein a novel composition of an ON chelate complex prepared using any ON and a divalent metal cation and methods for the suppression of anti-coagulation and or subcutaneous injection site reactions and or improved tolerability with oligonucleotides by the use of ON chelate complexes during oligonucleotide administration.

    摘要翻译： 本公开描述了任何寡核苷酸（ON）的不同二价2+金属阳离子的广泛活性螯合，而不管大小或改性。 这种螯合作用对于二价（或更高价）的阳离子是特异性的，并导致形成不像盐的寡核苷酸螯合络合物。 本文描述了使用任何ON和二价金属阳离子制备的ON螯合络合物的新组合物以及通过使用ON螯合物复合物抑制抗凝血和/或皮下注射部位反应和/或寡核苷酸的耐受性的方法 寡核苷酸给药。

    OLIGONUCLEOTIDE CHELATE COMPLEXES
    10.
    发明申请
    OLIGONUCLEOTIDE CHELATE COMPLEXES 有权
    寡核苷酸复合物

    公开(公告)号：US20130296410A1

    公开(公告)日：2013-11-07

    申请号：US13905318

    申请日：2013-05-30

    申请人： REPLICOR INC.

    发明人： Andrew VAILLANT ,  Michel BAZINET

    IPC分类号： A61K31/7088 ,  A61K31/713

    CPC分类号： A61K31/7088 ,  A61K9/0019 ,  A61K31/713 ,  A61K47/02

    摘要： The present disclosure describes the broadly active chelation of diverse divalent 2+ metal cations by any oligonucleotide (ON), regardless of size or modification. This chelation effect is specific to cations which are divalent (or of higher valency) and results in the formation of oligonucleotide chelate complexes which do not behave like salts. It is described herein a novel composition of an ON chelate complex prepared using any ON and a divalent metal cation and methods for the suppression of anti-coagulation and or subcutaneous injection site reactions and or improved tolerability with oligonucleotides by the use of ON chelate complexes during oligonucleotide administration.

    摘要翻译： 本公开描述了任何寡核苷酸（ON）的不同二价2+金属阳离子的广泛活性螯合，而不管大小或改性。 这种螯合作用对于二价（或更高价）的阳离子是特异性的，并导致形成不像盐的寡核苷酸螯合络合物。 本文描述了使用任何ON和二价金属阳离子制备的ON螯合络合物的新组合物以及通过使用ON螯合物复合物抑制抗凝血和/或皮下注射部位反应和/或寡核苷酸的耐受性的方法 寡核苷酸给药。