公开(公告)号：US20130338489A1

公开(公告)日：2013-12-19

申请号：US13992231

申请日：2011-12-07

申请人： Gordon Kim Prisk ,  Susan Roberta Hopkins ,  Richard Bruce Buxton ,  Rui Carlos Pereira De Sá ,  Rebecca Jean Theilmann ,  Matthew Vincent Cronin

发明人： Gordon Kim Prisk ,  Susan Roberta Hopkins ,  Richard Bruce Buxton ,  Rui Carlos Pereira De Sá ,  Rebecca Jean Theilmann ,  Matthew Vincent Cronin

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/08 ,  A61B5/0813 ,  G01R33/5601 ,  G01R33/56366

摘要： Methods, devices, and systems are disclosed for implementing a fully quantitative non-injectable contrast proton MRI technique to measure spatial ventilation-perfusion (VA/Q) matching and spatial distribution of ventilation and perfusion. In one aspect, a method using MRI to characterize ventilation and perfusion in a lung includes acquiring an MR image of the lung having MR data in a voxel and obtaining a breathing frequency parameter, determining a water density value, a specific ventilation value, and a perfusion value in at least one voxel of the MR image based on the MR data and using the water density value to determine an air content value, and determining a ventilation-perfusion ratio value that is the product of the specific ventilation value, the air content value, the inverse of the perfusion value, and the breathing frequency.

摘要翻译： 公开了用于实现全定量非注射对比质子MRI技术以测量空气通气灌注（VA / Q）匹配和通气和灌注的空间分布的方法，装置和系统。 在一个方面，使用MRI来表征肺中的通气和灌注的方法包括获取在体素中具有MR数据的肺的MR图像，并获得呼吸频率参数，确定水密度值，特定通气量和 基于MR数据在MR图像的至少一个体素中的灌注值，并且使用水密度值来确定空气含量值，以及确定作为特定通气量，空气含量的乘积的通气灌注比值 值，灌注值的倒数和呼吸频率。

公开(公告)号：US09750427B2

公开(公告)日：2017-09-05

申请号：US13992231

申请日：2011-12-07

申请人： Gordon Kim Prisk ,  Susan Roberta Hopkins ,  Richard Bruce Buxton ,  Rui Carlos Pereira De Sá ,  Rebecca Jean Theilmann ,  Matthew Vincent Cronin

发明人： Gordon Kim Prisk ,  Susan Roberta Hopkins ,  Richard Bruce Buxton ,  Rui Carlos Pereira De Sá ,  Rebecca Jean Theilmann ,  Matthew Vincent Cronin

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61B5/08 ,  G01R33/56 ,  G01R33/563

CPC分类号： A61B5/055 ,  A61B5/08 ,  A61B5/0813 ,  G01R33/5601 ,  G01R33/56366

摘要： Methods, devices, and systems are disclosed for implementing a fully quantitative non-injectable contrast proton MRI technique to measure spatial ventilation-perfusion (VA/Q) matching and spatial distribution of ventilation and perfusion. In one aspect, a method using MRI to characterize ventilation and perfusion in a lung includes acquiring an MR image of the lung having MR data in a voxel and obtaining a breathing frequency parameter, determining a water density value, a specific ventilation value, and a perfusion value in at least one voxel of the MR image based on the MR data and using the water density value to determine an air content value, and determining a ventilation-perfusion ratio value that is the product of the specific ventilation value, the air content value, the inverse of the perfusion value, and the breathing frequency.