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    Flavoring Systems for Pharmaceutical Compositions and Methods of Making Such Compositions
    2.
    发明申请
    Flavoring Systems for Pharmaceutical Compositions and Methods of Making Such Compositions 有权
    药物组合物调味剂系统及其制备方法

    公开(公告)号：US20100280055A1

    公开(公告)日：2010-11-04

    申请号：US12687479

    申请日：2010-01-14

    申请人： Laman Alani ,  Donald P. Gauwitz ,  Dilip Kaul ,  John M. Lipari ,  Soumojeet Ghosh ,  Kennan C. Marsh ,  Richard H. Whelan ,  Vanik D. Petrossian

    发明人： Laman Alani ,  Donald P. Gauwitz ,  Dilip Kaul ,  John M. Lipari ,  Soumojeet Ghosh ,  Kennan C. Marsh ,  Richard H. Whelan ,  Vanik D. Petrossian

    IPC分类号： A61K31/513 ,  A61K31/427 ,  A61P31/18

    CPC分类号： A61K47/46 ,  A61K9/0095 ,  A61K47/02 ,  A61K47/12

    摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.

    摘要翻译： 公开了一种用于液体药物组合物的调味体系和含有这种调味体系的药物组合物。 本发明的调味系统包括至少一种甜味剂，至少两种调味成分和至少一种选自柠檬酸，柠檬酸钠，氯化钠及其混合物的调味剂。 至少两种调味成分选自香草调味成分，薄荷调味成分，薄荷醇风味成分，棉花糖调味成分及其混合物。 一种或多种甜味剂包括甘油，甘草酸单铵盐，糖精钠，乙酰磺胺酸钾，高果糖玉米糖浆和/或其混合物。 本发明的药物组合物包括本发明的调味剂体系，溶剂体系和至少一种药物活性剂，例如洛匹那韦或其衍生物，利托那韦或其衍生物，或其混合物。 还公开了制备这种液体药物组合物的方法。

    Process for making low calorie fat-containing frozen dessert products having smooth, creamy, nongritty mouthfeel
    5.
    发明授权
    Process for making low calorie fat-containing frozen dessert products having smooth, creamy, nongritty mouthfeel 失效
    具有平滑性，耐候性，不锈钢柔软性的低卡路里含脂肪冷冻冷冻产品的方法

    公开(公告)号：US5084295A

    公开(公告)日：1992-01-28

    申请号：US474189

    申请日：1990-02-02

    申请人： Richard H. Whelan ,  Marvin J. Rudolph ,  Vanik D. Petrossian

    发明人： Richard H. Whelan ,  Marvin J. Rudolph ,  Vanik D. Petrossian

    IPC分类号： A23G9/00 ,  A23G9/04 ,  A23G9/30 ,  A23G9/32 ,  A23G9/34 ,  A23G9/44 ,  A23G9/52

    CPC分类号： A23G9/32 ,  A23G9/305 ,  A23G9/327 ,  A23G9/34 ,  Y10S426/804

    摘要： Low calorie frozen desserts, in particular ice cream-like products, having a smooth, creamy, nongritty mouthfeel are disclosed. These frozen desserts contain fat comprising from about 30 to 100% of certain edible, wholly or partially nondigestible intermediate melting polyol polyesters, milk solids other than fat, sweetener, oil-in-water emulsifier, a flavoring substance, and water. The fat is substantially homogeneously dispersed in the aqueous phase as emulsified fat particles having an average particle size of about 5 microns or less. These frozen desserts are obtained by a process which initially involves the formation of a preemulsion by homogenizing a mixture which consists essentially of these intermediate melting polyol polyesters and only a portion of the other dessert ingredients. This preemulsion is then combined with the remaining dessert ingredients, homogenized, pasteurized, and at least partially frozen to provide the frozen desserts.

    摘要翻译： 公开了低热量冷冻甜点，特别是冰淇淋样产品，具有光滑，乳脂状，无味口感。 这些冷冻甜点含有脂肪，其含有约30-100％的某些可食用，全部或部分不易消化的中间熔融多元醇多酯，除脂肪，甜味剂，水包油乳化剂，调味物质和水之外的乳固体。 脂肪基本均匀地分散在水相中，作为具有约5微米或更小的平均粒度的乳化脂肪颗粒。 这些冷冻甜点是通过一种方法获得的，该方法最初涉及通过使基本上由这些中间熔融多元醇多酯组成的混合物均匀化而形成预乳液，并且仅使用其它甜点成分的一部分。 然后将该预乳液与剩余的甜食成分组合，均化，巴氏消毒，并至少部分冷冻以提供冷冻的甜点。