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    Flavoring Systems for Pharmaceutical Compositions and Methods of Making Such Compositions
    2.
    发明申请
    Flavoring Systems for Pharmaceutical Compositions and Methods of Making Such Compositions 有权
    药物组合物调味剂系统及其制备方法

    公开(公告)号：US20100280055A1

    公开(公告)日：2010-11-04

    申请号：US12687479

    申请日：2010-01-14

    申请人： Laman Alani ,  Donald P. Gauwitz ,  Dilip Kaul ,  John M. Lipari ,  Soumojeet Ghosh ,  Kennan C. Marsh ,  Richard H. Whelan ,  Vanik D. Petrossian

    发明人： Laman Alani ,  Donald P. Gauwitz ,  Dilip Kaul ,  John M. Lipari ,  Soumojeet Ghosh ,  Kennan C. Marsh ,  Richard H. Whelan ,  Vanik D. Petrossian

    IPC分类号： A61K31/513 ,  A61K31/427 ,  A61P31/18

    CPC分类号： A61K47/46 ,  A61K9/0095 ,  A61K47/02 ,  A61K47/12

    摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.

    摘要翻译： 公开了一种用于液体药物组合物的调味体系和含有这种调味体系的药物组合物。 本发明的调味系统包括至少一种甜味剂，至少两种调味成分和至少一种选自柠檬酸，柠檬酸钠，氯化钠及其混合物的调味剂。 至少两种调味成分选自香草调味成分，薄荷调味成分，薄荷醇风味成分，棉花糖调味成分及其混合物。 一种或多种甜味剂包括甘油，甘草酸单铵盐，糖精钠，乙酰磺胺酸钾，高果糖玉米糖浆和/或其混合物。 本发明的药物组合物包括本发明的调味剂体系，溶剂体系和至少一种药物活性剂，例如洛匹那韦或其衍生物，利托那韦或其衍生物，或其混合物。 还公开了制备这种液体药物组合物的方法。

    Flavoring systems for pharmaceutical compositions and methods of making such compositions
    5.
    发明申请
    Flavoring systems for pharmaceutical compositions and methods of making such compositions 审中-公开
    用于药物组合物的调味剂系统和制备这种组合物的方法

    公开(公告)号：US20050191324A1

    公开(公告)日：2005-09-01

    申请号：US11118733

    申请日：2005-04-29

    申请人： Laman Alani ,  Donald Gauwitz ,  Dilip Kaul ,  John Lipari ,  Soumojeet Ghosh ,  Kennan Marsh ,  Richard Whelan ,  Vanik Petrossian

    发明人： Laman Alani ,  Donald Gauwitz ,  Dilip Kaul ,  John Lipari ,  Soumojeet Ghosh ,  Kennan Marsh ,  Richard Whelan ,  Vanik Petrossian

    IPC分类号： A61K9/00 ,  A61K31/7056

    CPC分类号： A61K47/46 ,  A61K9/0095 ,  A61K47/02 ,  A61K47/12

    摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.

    摘要翻译： 公开了一种用于液体药物组合物的调味体系和含有这种调味体系的药物组合物。 本发明的调味系统包括至少一种甜味剂，至少两种调味成分和至少一种选自柠檬酸，柠檬酸钠，氯化钠及其混合物的调味剂。 至少两种调味成分选自香草调味成分，薄荷调味成分，薄荷醇风味成分，棉花糖调味成分及其混合物。 一种或多种甜味剂包括甘油，甘草酸单铵盐，糖精钠，乙酰磺胺酸钾，高果糖玉米糖浆和/或其混合物。 本发明的药物组合物包括本发明的调味剂体系，溶剂体系和至少一种药物活性剂，例如洛匹那韦或其衍生物，利托那韦或其衍生物，或其混合物。 还公开了制备这种液体药物组合物的方法。

    Pharmaceutical formulations
    7.
    发明授权
    Pharmaceutical formulations 有权
    药物制剂

    公开(公告)号：US07981911B2

    公开(公告)日：2011-07-19

    申请号：US12183507

    申请日：2008-07-31

    申请人： Laman Alani ,  Soumojeet Ghosh

    发明人： Laman Alani ,  Soumojeet Ghosh

    IPC分类号： A61K31/25

    CPC分类号： A61K31/425

    摘要： Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium and/or long chain fatty acid, or mixtures thereof, a pharmaceutically acceptable alcohol, and water.

    摘要翻译： 提供改进的药物组合物，其包含一种或多种在培养基和/或长链脂肪酸或其混合物，药学上可接受的醇和水中具有改善的溶解性质的增溶的HIV蛋白酶抑制化合物。

    Taste-Masked Tablets and Granules
    9.
    发明申请
    Taste-Masked Tablets and Granules 审中-公开
    味道掩蔽的片剂和颗粒

    公开(公告)号：US20090136570A1

    公开(公告)日：2009-05-28

    申请号：US12087827

    申请日：2007-01-16

    申请人： Bhagwant Rege ,  Kimberly Kaighn ,  Soumojeet Ghosh ,  Laman Alani

    发明人： Bhagwant Rege ,  Kimberly Kaighn ,  Soumojeet Ghosh ,  Laman Alani

    IPC分类号： A61K9/20 ,  A61K31/513 ,  A61K31/519 ,  A61P31/18 ,  A61K31/506

    CPC分类号： A61K9/2054 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095 ,  A61K31/70

    摘要： Orally administered, taste-masked tablets and granules contain (a) a hydroxypyrimidinone carboxamide, a hydroxy-tetrahydropyridopyrimidinone carboxamide, or a related carboxamide compound, or a pharmaceutically acceptable salt thereof, (b) a taste-masking polymer, (c) a superdisintegrant, and optionally other excipients. The carboxamide compound is an HIV integrase inhibitor, and the tablets and granules are suitable for use in the inhibition of HIV integrase, the treatment or prophylaxis of HIV infection, and the treatment or prophylaxis or delay in the onset of AIDS.

    摘要翻译： 口服给药的掩味片和颗粒剂含有（a）羟基嘧啶酮羧酰胺，羟基四氢吡啶并嘧啶酮羧酰胺或相关的羧酰胺化合物或其药学上可接受的盐，（b）掩味聚合物，（c）超级崩解剂 ，和任选的其它赋形剂。 甲酰胺化合物是HIV整合酶抑制剂，片剂和颗粒剂适用于抑制HIV整合酶，治疗或预防HIV感染，以及治疗或预防或延迟艾滋病的发作。