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    CROSS-REACTIVE DETERMINANTS AND METHODS FOR THEIR IDENTIFICATION
    1.
    发明申请
    CROSS-REACTIVE DETERMINANTS AND METHODS FOR THEIR IDENTIFICATION 审中-公开
    交叉反应性决定因素及其鉴定方法

    公开(公告)号：US20150293118A1

    公开(公告)日：2015-10-15

    申请号：US14696904

    申请日：2015-04-27

    申请人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Keil

    发明人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Keil

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6854 ,  A61K39/102 ,  A61K2039/552 ,  G01N33/5052 ,  G01N33/6878 ,  G01N2333/285

    摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.

    摘要翻译： 提供了用于确定包含交叉反应性抗原决定簇的免疫交叉反应性分子的组合物和方法，特别是用于确定包含交叉反应性抗原决定簇的蛋白质，特别是用于基于血清学筛选使用顺序免疫挑战来测定交叉反应的蛋白质 包括确定交叉反应性副猪嗜血菌蛋白。 还提供了使用分子进行诊断的组合物，疫苗和试剂盒，以及用于预防或治疗与感染因子，特别是感染性微生物相关的疾病，病症，状况或症状的方法，特别是用于预防或治疗疾病，病症 ，病症或与副猪嗜血菌感染相关的症状。

    AIR-FREIGHTABLE CONTAINMENT CAP FOR CONTAINING A SUBSEA WELL
    2.
    发明申请
    AIR-FREIGHTABLE CONTAINMENT CAP FOR CONTAINING A SUBSEA WELL 审中-公开
    含有下列物品的空中包容舱

    公开(公告)号：US20120318522A1

    公开(公告)日：2012-12-20

    申请号：US13468872

    申请日：2012-05-10

    申请人： Robert Winfield Franklin ,  Richard Harland ,  Stuart Douglas Rettie ,  Roy Bryant Shilling, III

    发明人： Robert Winfield Franklin ,  Richard Harland ,  Stuart Douglas Rettie ,  Roy Bryant Shilling, III

    IPC分类号： E21B33/035

    CPC分类号： E21B43/0122

    摘要： A modular containment cap for containing a subsea wellbore discharging hydrocarbons comprises a lower assembly including a spool body having an upper end, a lower end opposite the upper end, and a first throughbore extending from the upper end to the lower end. In addition the containment cap comprises an upper assembly including a spool piece having an upper end, a lower end opposite the upper end, a throughbore extending from the upper end to the lower end, and a first spool piece valve disposed in the throughbore. The first spool piece valve is configured to control the flow of fluids through the throughbore of the spool piece. The upper end of the spool body is releasably connected to the lower end of the spool piece, and the first throughbore of the spool body is coaxially aligned with and in fluid communication with the throughbore of the spool piece.

    摘要翻译： 用于容纳排放烃类的海底井筒的模块化容纳盖包括下部组件，其包括具有上端，与上端相对的下端和从上端延伸到下端的第一通孔的卷轴体。 此外，容纳帽包括上部组件，其包括具有上端，与上端相对的下端，从上端延伸到下端的通孔和设置在通孔中的第一阀芯阀的阀芯。 第一卷轴阀被构造成控制通过卷轴件的通孔的流体的流动。 卷轴体的上端可释放地连接到卷轴件的下端，并且卷轴主体的第一通孔与卷轴件的通孔同轴地对准并与其流体连通。

    SUBSEA CONTAINMENT CAP ADAPTERS
    3.
    发明申请
    SUBSEA CONTAINMENT CAP ADAPTERS 审中-公开
    SUBSEA容纳帽适配器

    公开(公告)号：US20120318521A1

    公开(公告)日：2012-12-20

    申请号：US13468845

    申请日：2012-05-10

    申请人： Robert Winfield Franklin ,  Richard Harland ,  Stuart Douglas Rettie ,  Roy Bryant Shilling, III

    发明人： Robert Winfield Franklin ,  Richard Harland ,  Stuart Douglas Rettie ,  Roy Bryant Shilling, III

    IPC分类号： E21B33/076

    CPC分类号： E21B43/0122

    摘要： A method for controlling hydrocarbons flowing from a subsea structure comprises lowering an adapter from the surface to a subsea structure. The adapter has a through bore extending between an upper connector having a first connector profile and a lower connector having a second connector profile that is different than the first connector profile. In addition, the method comprises coupling the lower connector of the adapter to the subsea structure. Further, the method comprises lowering a containment cap from the surface to the adapter. Still further, the method comprises coupling the containment cap to the upper connector of the adapter.

    摘要翻译： 用于控制从海底结构流动的烃的方法包括将适配器从表面降低到海底结构。 适配器具有在具有第一连接器轮廓的上连接器和具有与第一连接器轮廓不同的第二连接器轮廓的下连接器之间延伸的通孔。 此外，该方法包括将适配器的下连接器连接到海底结构。 此外，该方法包括将容纳帽从表面降低到适配器。 此外，该方法包括将容纳盖连接到适配器的上连接器。

    CROSS-REACTIVE DETERMINANTS AND METHODS FOR THEIR IDENTIFICATION
    5.
    发明申请
    CROSS-REACTIVE DETERMINANTS AND METHODS FOR THEIR IDENTIFICATION 有权
    交叉反应性决定因素及其鉴定方法

    公开(公告)号：US20110014225A1

    公开(公告)日：2011-01-20

    申请号：US12934654

    申请日：2009-03-20

    申请人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Kiel

    发明人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Kiel

    IPC分类号： A61K39/02 ,  G01N33/53 ,  C07K7/06 ,  C07K7/08 ,  A61P31/04

    CPC分类号： G01N33/6854 ,  A61K39/102 ,  A61K2039/552 ,  G01N33/5052 ,  G01N33/6878 ,  G01N2333/285

    摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.

    摘要翻译： 提供了用于确定包含交叉反应性抗原决定簇的免疫交叉反应性分子的组合物和方法，特别是用于确定包含交叉反应性抗原决定簇的蛋白质，特别是用于基于血清学筛选使用顺序免疫挑战来测定交叉反应的蛋白质 包括确定交叉反应性副猪嗜血菌蛋白。 还提供了使用分子进行诊断的组合物，疫苗和试剂盒，以及用于预防或治疗与感染因子，特别是感染性微生物相关的疾病，病症，状况或症状的方法，特别是用于预防或治疗疾病，病症 ，病症或与副猪嗜血菌感染相关的症状。

    Cross-reactive determinants and methods for their identification
    6.
    发明授权
    Cross-reactive determinants and methods for their identification 有权
    交叉反应决定因素及其鉴定方法

    公开(公告)号：US09046528B2

    公开(公告)日：2015-06-02

    申请号：US12934654

    申请日：2009-03-20

    申请人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Keil

    发明人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Keil

    IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/102 ,  G01N33/68 ,  G01N33/50

    CPC分类号： G01N33/6854 ,  A61K39/102 ,  A61K2039/552 ,  G01N33/5052 ,  G01N33/6878 ,  G01N2333/285

    摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.

    摘要翻译： 提供了用于确定包含交叉反应性抗原决定簇的免疫交叉反应性分子的组合物和方法，特别是用于确定包含交叉反应性抗原决定簇的蛋白质，特别是用于基于血清学筛选使用顺序免疫挑战来测定交叉反应的蛋白质 包括确定交叉反应性副猪嗜血菌蛋白。 还提供了使用分子进行诊断的组合物，疫苗和试剂盒，以及用于预防或治疗与感染因子，特别是感染性微生物相关的疾病，病症，状况或症状的方法，特别是用于预防或治疗疾病，病症 ，病症或与副猪嗜血菌感染相关的症状。

    Manual tong safety latch
    8.
    发明授权
    Manual tong safety latch 有权

    公开(公告)号：US06571667B2

    公开(公告)日：2003-06-03

    申请号：US09731285

    申请日：2000-12-06

    申请人： Herman Paul Price ,  Richard Harland Miller ,  William Harold Macon

    发明人： Herman Paul Price ,  Richard Harland Miller ,  William Harold Macon

    IPC分类号： B25B1350

    CPC分类号： E21B19/161

    摘要： A latch device for a manual tong apparatus that incorporates a secondary catch mechanism is presented. Such a secondary catch would assist in maintaining the tong assembly in it's closed position during a reversing operation or at a time when load applied to the manual tong device in the gripping direction is very low. Additionally the secondary catch would also provide some additional protection by holding the tong assembly together in the event of a failure of certain tong components. The mechanism of the secondary catch is spring loaded and operates through two secondary up-down catch arms that are deactivated by swinging a handle in the direction that corresponds to the operator's natural motion to open the lug jaw.

    Morphogenic proteins
    9.
    发明授权
    Morphogenic proteins 失效

    公开(公告)号：US06432410B1

    公开(公告)日：2002-08-13

    申请号：US09040229

    申请日：1998-03-13

    申请人： Richard Harland ,  David Hsu

    发明人： Richard Harland ,  David Hsu

    IPC分类号： A61K3816

    CPC分类号： C07K14/475

    摘要： DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and gremlin proteins and related nucleic acids are provided. Included are natural DAN and gremlin homologs from several species and proteins comprising a DAN or gremlin domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.