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公开(公告)号：US5049374A
公开(公告)日：1991-09-17
申请号：US441984
申请日：1989-11-28
CPC分类号： A61K9/1676 , A61K51/1258 , A61K2123/00
摘要： A stabilized oral pharmaceutical bead dosage form of sodium iodide I-131 is described. The sodium iodide I-131 is dissolved in a polymer film and the polymer film is applied by conventional coating technology which affixes the sodium iodide I-131 to inert substrate beads. The film also stabilizes the sodium iodide I-131 from chemical degradation.The utility of the bead dosage form is that it provides a decreased radiation hazard over that of handling a sodium iodide I-131 liquid. At the time of manufacture a specified amount of sodium iodide I-131 is applied to the substrate beads. The sodium idoide I-131 containing beads are then stored appropriately until dispensed by the pharmacist or physician. The key advantage of this system is that dispensing flexibility is maintained because as the sodium iodide I-131 undergoes radioactive decay the pharmacist or physician can compensate for the loss by dispensing a larger quantity of the coated beads to constitute the prescribed sodium iodide I-131 dose. Then just prior to patient administration, the beads can be filled into a single hard gelatin capsule of if the patient prefers, the beads can be dispensed in water, orange juice, apple sauce or any suitable liquid or food intended for oral administration.This dosage form described herein minimizes the radiation hazard from the time of manufacture to the time of administration, provides dosing flexibility to the pharmacist and physician and offers the patient numerous options in terms of dosage form administration.
摘要翻译： 描述了碘化钠I-131的稳定的口服药物珠剂量形式。 将碘化钠I-131溶解在聚合物膜中，并通过常规涂覆技术涂覆聚合物膜，其将碘化钠I-131固定在惰性底物珠上。 该膜还使化学降解的碘化钠I-131稳定。 珠粒剂型的用途是比处理碘化钠I-131液体提供的辐射危害降低。 在制造时，将特定量的碘化钠I-131施加到基材珠上。 然后储存含有独特的含有I-131的珠子，由药剂师或医师分配。 该系统的主要优点是保持分配灵活性，因为碘化钠I-131经历放射性衰变，药剂师或医师可以通过分配更多量的涂覆珠来构成规定的碘化钠I-131来补偿损失 剂量。 然后就在患者给药之前，珠可以填充到单一硬明胶胶囊中，如果患者喜欢，则可以将珠子分配在水，橙汁，苹果酱或任何适合于口服给药的液体或食物中。 本文所述的剂型使从制造时到给药时间的辐射危害最小化，向药剂师和医师提供给药灵活性，并且在剂型给药方面向患者提供了多种选择。
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公开(公告)号：USD359554S
公开(公告)日：1995-06-20
申请号：US26882
申请日：1994-02-23
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公开(公告)号：US5437724A
公开(公告)日：1995-08-01
申请号：US137656
申请日：1993-10-15
CPC分类号： C25D15/00
摘要： The present invention relates to a tool for accurately controlling the location, volume and containment of an abrasive grit material during a plating operation wherein the grit material and a matrix metal are deposited onto a tip portion of at least one workpiece. The tool of the present invention has an inner component with slots for receiving the workpieces to be coated. The tool also has an outer components having a plurality of through slots for permitting a plating solution to flow therethrough and into a space defined by the inner and outer components. The tool further has a slot defined by portions of the inner and outer component for introducing the abrasive grit material into the space. A screen is provided over the slots in the outer component. The screen helps maintain the abrasive grit material within the space while permitting plating solution to flow into the space. The tool of the present invention further has a trough for collecting unused grit material. A method for forming a coating on a tip portion of a workpiece or workpieces using the tool of the present invention is also disclosed.
摘要翻译： 本发明涉及一种用于在电镀操作期间精确地控制磨料砂粒材料的位置，体积和容纳的工具，其中砂粒材料和基质金属沉积在至少一个工件的尖端部分上。 本发明的工具具有内部部件，其具有用于接收待涂覆的工件的槽。 该工具还具有外部部件，其具有多个通孔，用于允许电镀溶液流过其中并进入由内部和外部部件限定的空间。 该工具还具有由内部和外部部件的部分限定的槽，用于将磨料砂粒材料引入该空间。 在外部组件的槽上提供一个屏幕。 屏幕有助于将磨料砂粒材料保持在空间内，同时允许电镀液流入空间。 本发明的工具还具有用于收集未使用的砂砾材料的槽。 还公开了使用本发明的工具在工件或工件的尖端部分上形成涂层的方法。
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公开(公告)号：US5622721A
公开(公告)日：1997-04-22
申请号：US307495
申请日：1994-09-14
IPC分类号： A61K9/20 , A61K9/26 , A61K9/28 , A61K9/32 , A61K9/50 , A61K9/54 , A61K31/675 , A61K47/30 , A61K47/32 , A61K47/38 , A61P3/14 , A61P5/18 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , A61K9/16
CPC分类号： A61K31/675 , A61K9/2846 , A61K9/2866 , A61K9/5026 , A61K9/5078
摘要： The present invention is directed to a novel enteric-coated oral dosage form of a risedronate active ingredient comprised of a safe and effective amount of a pharmaceutical composition which is comprised of a risedronate active ingredient and pharmaceutically-acceptable excipients. Said dosage forms prohibit the exposure of the risedronate active ingredient to the epithelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach and thereby protects said tissues from erosion, ulceration or other like irritation. Accordingly, the said dosage forms effect the delivery to the lower gastrointestinal tract of said human or other mammal of a safe and effective amount of the risedronate active ingredient, and substantially alleviate the esophagitis or esophageal irritation which occasionally accompanies the oral administration of risedronate active ingredients.
摘要翻译： 本发明涉及由利塞膦酸盐活性成分组成的新型肠溶衣口服剂型，其包含由利塞膦酸盐活性成分和药学上可接受的赋形剂组成的安全有效量的药物组合物。 所述剂型禁止将利塞膦酸盐活性成分暴露于颊腔，咽，食管和胃的上皮和粘膜组织，从而保护所述组织免受侵蚀，溃疡或其它类似的刺激。 因此，所述剂型影响将所述人或其他哺乳动物的下胃肠道递送至安全有效量的利塞膦酸酯活性成分，并且基本上减轻偶尔伴随利塞膦酸盐活性成分口服的食管炎或食管刺激 。
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公开(公告)号：US5032406A
公开(公告)日：1991-07-16
申请号：US314672
申请日：1989-02-21
CPC分类号： A61K9/209
摘要： The present invention provides a dual-action tablet composition comprising:(a) an outer tablet comprising a first dose of active ingredient dispersed in a pH independent hydrophilic polymer matrix; and(b) an inner tablet comprising a second dose of active ingredient in a rapidly disintegrating excipient base.This dual-action tablet is especially efficacious for those active ingredients which have half lives of less than two hours and which experience decreased absorption efficiency in the lower gastrointestinal tract. Among the preferred dual-action tablet compositions is one wherein the active ingredient in both the inner and outer tablets is guaifenesin. Upon administration, the outer tablet provides a controlled release of the active ingredient while the inner tablet gives a second dose of active ingredient after the outer tablet has partially dissolved.
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