公开(公告)号：US06177440B1

公开(公告)日：2001-01-23

申请号：US09063066

申请日：1998-04-21

申请人： Nicholas James Bach ,  Susan Elizabeth Draheim ,  Robert Delane Dillard ,  Edward David Mihelich ,  Jason Scott Sawyer ,  Douglas Wade Beight ,  Michael LeRoy Phillips ,  Tulio Suarez ,  Daniel Jon Sall ,  Jolie Anne Bastian ,  Michael Lyle Denney ,  Gary Alan Hite ,  Michael Dean Kinnick ,  Robert Theodore Vasileff ,  John Michael Morin, Jr. ,  Ho-Shen Lin ,  Michael Enrico Richett ,  Richard Waltz Harper ,  John McNeill McGill, III ,  Benjamin Alan Anderson ,  Nancy Kay Harn ,  Richard James Loncharich ,  Richard Walter Schevitz

发明人： Nicholas James Bach ,  Susan Elizabeth Draheim ,  Robert Delane Dillard ,  Edward David Mihelich ,  Jason Scott Sawyer ,  Douglas Wade Beight ,  Michael LeRoy Phillips ,  Tulio Suarez ,  Daniel Jon Sall ,  Jolie Anne Bastian ,  Michael Lyle Denney ,  Gary Alan Hite ,  Michael Dean Kinnick ,  Robert Theodore Vasileff ,  John Michael Morin, Jr. ,  Ho-Shen Lin ,  Michael Enrico Richett ,  Richard Waltz Harper ,  John McNeill McGill, III ,  Benjamin Alan Anderson ,  Nancy Kay Harn ,  Richard James Loncharich ,  Richard Walter Schevitz

IPC分类号： A61K3144

CPC分类号： C07D209/88

摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.

摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。

公开(公告)号：US06713645B1

公开(公告)日：2004-03-30

申请号：US09688106

申请日：2000-10-13

申请人： Nicholas James Bach ,  Susan Elizabeth Draheim ,  Robert Delane Dillard ,  Edward David Mihelich ,  Jason Scott Sawyer ,  Douglas Wade Beight ,  Michael LeRoy Phillips ,  Tulio Suarez ,  Daniel Jon Sall ,  Jolie Anne Bastian ,  Michael Lyle Denney ,  Gary Alan Hite ,  Michael Dean Kinnick ,  Robert Theodore Vasileff ,  John Michael Morin, Jr. ,  Ho-Shen Lin ,  Michael Enrico Richett ,  Richard Waltz Harper ,  John McNeill McGill, III ,  Benjamin Alan Anderson ,  Nancy Kay Harn ,  Richard James Loncharich ,  Richard Walter Schevitz

发明人： Nicholas James Bach ,  Susan Elizabeth Draheim ,  Robert Delane Dillard ,  Edward David Mihelich ,  Jason Scott Sawyer ,  Douglas Wade Beight ,  Michael LeRoy Phillips ,  Tulio Suarez ,  Daniel Jon Sall ,  Jolie Anne Bastian ,  Michael Lyle Denney ,  Gary Alan Hite ,  Michael Dean Kinnick ,  Robert Theodore Vasileff ,  John Michael Morin, Jr. ,  Ho-Shen Lin ,  Michael Enrico Richett ,  Richard Waltz Harper ,  John McNeill McGill, III ,  Benjamin Alan Anderson ,  Nancy Kay Harn ,  Richard James Loncharich ,  Richard Walter Schevitz

IPC分类号： C07C6976

CPC分类号： C07D409/04 ,  C07D209/88 ,  C07F9/5728

摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.

摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。