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公开(公告)号:US20140127230A1
公开(公告)日:2014-05-08
申请号:US14059241
申请日:2013-10-21
申请人: Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
发明人: Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC分类号: C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及结合转化生长因子β(TGFβb)的抗体分子,特别是抗体分子及其应用。 更具体地说,本发明涉及结合并优选中和TGF-β1,TGF-β2和TGFβb3,所谓“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US20110008364A1
公开(公告)日:2011-01-13
申请号:US12724347
申请日:2010-03-15
申请人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
发明人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC分类号: A61K39/395 , C07K16/22 , C07H21/04 , A61P35/00 , A61P37/02 , C12N5/10 , C12P21/00 , C12N5/071 , C12N5/09
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及结合转化生长因子β(TGFβb)的抗体分子,特别是抗体分子及其应用。 更具体地说,本发明涉及结合并优选中和TGF-β1,TGF-β2和TGFβb3,所谓“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US08383780B2
公开(公告)日:2013-02-26
申请号:US12724347
申请日:2010-03-15
申请人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
发明人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC分类号: C07K16/22 , C07K14/495 , A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及结合转化生长因子β(TGFβb)的抗体分子,特别是抗体分子及其应用。 更具体地,本发明涉及结合并优选中和TGF-β1,TGF-β2和TGFβb的所述抗体分子,所谓的泛特异性抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US08591901B2
公开(公告)日:2013-11-26
申请号:US13615388
申请日:2012-09-13
申请人: Steven R Ledbetter , Celia P Hart , Robert G Holgate , Lutz U Jermutus , Catriona L Buchanan , Alexander R Duncan , Donna K Finch
发明人: Steven R Ledbetter , Celia P Hart , Robert G Holgate , Lutz U Jermutus , Catriona L Buchanan , Alexander R Duncan , Donna K Finch
IPC分类号: A61K39/395 , C07K16/22 , C07K14/495
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及抗体分子,特别是结合转化生长因子β(TGFβ)的抗体分子及其用途。 更具体地,本发明涉及结合并优选中和TGFbeta1,TGFbeta2和TGFbeta3,所谓的“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US20130243788A1
公开(公告)日:2013-09-19
申请号:US13615388
申请日:2012-09-13
申请人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
发明人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC分类号: C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind. Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及抗体分子,特别是结合的抗体分子。 转化生长因子β(TGFβ)及其用途。 更具体地,本发明涉及结合并优选中和TGbeta1,TGFbeta2和TGFbeta3,所谓的“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US07723486B2
公开(公告)日:2010-05-25
申请号:US11350906
申请日:2006-02-08
申请人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
发明人: Steven R. Ledbetter , Celia P. Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC分类号: C07K16/22 , C07K14/495
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及结合转化生长因子β(TGFβb)的抗体分子,特别是抗体分子及其应用。 更具体地说,本发明涉及结合并优选中和TGF-β1,TGF-β2和TGFβb3,所谓“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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