公开(公告)号：US06254736B1

公开(公告)日：2001-07-03

申请号：US09386562

申请日：1999-08-31

申请人： Robert Kitchel Earl ,  Brian A. Heald

发明人： Robert Kitchel Earl ,  Brian A. Heald

IPC分类号： B01J1908

CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  Y10S435/817

摘要： There is disclosed a method of selectively increasing the hydrophilicity of a web, such as a plastic glucose electrochemical test strip. The web is corona arc treated, and a film of water is selectively applied to the web where a reduction of the effect of the initial corona treatment is desired. The water is then removed by drying.

摘要翻译： 公开了一种选择性地提高纤维网亲水性的方法，例如塑料葡萄糖电化学测试条。 网被电晕处理，并且选择性地将水膜施加到幅材上，其中需要降低初始电晕处理的效果。 然后通过干燥除去水。

公开(公告)号：US06270637B1

公开(公告)日：2001-08-07

申请号：US09386210

申请日：1999-08-31

申请人： William F. Crismore ,  Nigel A. Surridge ,  Daniel R. McMinn ,  Richard J. Bodensteiner ,  Eric R. Diebold ,  R. Dale Delk ,  David W. Burke ,  Jiaxiong Jason Ho ,  Robert Kitchel Earl ,  Brian A. Heald

发明人： William F. Crismore ,  Nigel A. Surridge ,  Daniel R. McMinn ,  Richard J. Bodensteiner ,  Eric R. Diebold ,  R. Dale Delk ,  David W. Burke ,  Jiaxiong Jason Ho ,  Robert Kitchel Earl ,  Brian A. Heald

IPC分类号： G01N2726

CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  Y10S435/817

摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.

摘要翻译： 一种具有四个新特征的电化学生物传感器测试条。 测试条包括针对带样品应用端口的位置的触感的缩进。 样品应用端口通向包括测试试剂的毛细管测试室。 湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和 由测试用户进行机械操作。 毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行 测试。 测试条还可以包括位于样品应用端口处的凹口。 缺口减少了称为“剂量犹豫”的现象。

公开(公告)号：USRE41309E1

公开(公告)日：2010-05-04

申请号：US10409721

申请日：2003-04-09

申请人： William F. Crismore ,  Nigel A. Surridge ,  Daniel R. McMinn ,  Richard J. Bodensteiner ,  Eric R. Diebold ,  R. Dale Delk ,  David W. Burke ,  Jiaxiong Jason Ho ,  Robert Kitchel Earl ,  Brian A. Heald

发明人： William F. Crismore ,  Nigel A. Surridge ,  Daniel R. McMinn ,  Richard J. Bodensteiner ,  Eric R. Diebold ,  R. Dale Delk ,  David W. Burke ,  Jiaxiong Jason Ho ,  Robert Kitchel Earl ,  Brian A. Heald

IPC分类号： G01N33/48

CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  Y10S435/817

摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.

摘要翻译： 一种具有四个新特征的电化学生物传感器测试条。 测试条包括针对带样品应用端口的位置的触感的缩进。 样品应用端口通向包括测试试剂的毛细管测试室。 湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和 由测试用户进行机械操作。 毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行 测试。 测试条还可以包括位于样品应用端口处的凹口。 缺口减少了称为“剂量犹豫”的现象。

公开(公告)号：US5997817A

公开(公告)日：1999-12-07

申请号：US985840

申请日：1997-12-05

申请人： William F. Crismore ,  Nigel A. Surridge ,  Daniel R. McMinn ,  Richard J. Bodensteiner ,  Eric R. Diebold ,  R. Dale Delk ,  David W. Burke ,  Jiaxiong Jason Ho ,  Robert Kitchel Earl ,  Brian A. Heald

发明人： William F. Crismore ,  Nigel A. Surridge ,  Daniel R. McMinn ,  Richard J. Bodensteiner ,  Eric R. Diebold ,  R. Dale Delk ,  David W. Burke ,  Jiaxiong Jason Ho ,  Robert Kitchel Earl ,  Brian A. Heald

IPC分类号： G01N27/28 ,  C12M1/34 ,  C12Q1/00 ,  G01N27/00 ,  G01N27/02 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487 ,  G01N33/543 ,  G01N33/66 ,  G01N33/48

CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  Y10S435/817

摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a "fill to here" line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called "dose hesitation".

摘要翻译： 一种具有四个新特征的电化学生物传感器测试条。 测试条包括针对带样品应用端口的位置的触感的缩进。 样品应用端口通向包括测试试剂的毛细管测试室。 湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和 由测试用户进行机械操作。 毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行 测试。 测试条还可以包括位于样品应用端口处的凹口。 缺口减少了称为“剂量犹豫”的现象。