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    Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
    1.
    发明授权
    Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives 失效
    环庚三烯[b] [1,4]二氮杂[6,7,1-hi]吲哚和衍生物

    公开(公告)号：US06858604B2

    公开(公告)日：2005-02-22

    申请号：US10016743

    申请日：2001-11-02

    申请人： Annmarie Louise Sabb ,  Robert Lewis Vogel

    发明人： Annmarie Louise Sabb ,  Robert Lewis Vogel

    IPC分类号： A61K31/551 ,  A61K31/5517 ,  A61P3/04 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  C07D209/00 ,  C07D243/00 ,  C07D487/06 ,  A61K31/55

    CPC分类号： C07D487/06

    摘要： This invention provides compounds of the formula: wherein R1 and R2 are each, independently, H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; R3 and R4 are each, independently, H, alkyl or cycloalkyl; R5 is H or alkyl; R6 is H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

    摘要翻译： 本发明提供下式的化合物：其中R 1和R 2各自独立地为H，烷基，环烷基，-CH 2 - 环烷基，烷氧基，卤素，氟化烷基，-CN，-NH-SO 2 - 烷基，-SO 2 -NH- 烷基，烷基酰胺，氨基，烷基氨基，二烷基氨基，氟化烷氧基，酰基或苯甲酰基或噻吩甲酰基; R 3和R 4各自独立地为H，烷基或环烷基; R5是H或烷基; R6为H或; 虚线表示可选的双键; 或其药学上可接受的盐，以及利用这些化合物治疗或预防包括强迫症，抑郁症，焦虑症，广泛性焦虑症，精神分裂症，偏头痛，睡眠障碍，进食障碍，肥胖症，癫痫症， 和脊髓损伤。

    [1,4]diazepino [6,7,1-jk ]carbazoles and derivatives
    2.
    发明授权
    [1,4]diazepino [6,7,1-jk ]carbazoles and derivatives 失效
    [1,4]二氮杂[6,7,1-jk]咔唑及其衍生物

    公开(公告)号：US06503900B2

    公开(公告)日：2003-01-07

    申请号：US10017738

    申请日：2001-11-02

    申请人： Annmarie Louise Sabb ,  Gregory Scott Welmaker ,  Robert Lewis Vogel ,  Joan Eileen Sabalski

    发明人： Annmarie Louise Sabb ,  Gregory Scott Welmaker ,  Robert Lewis Vogel ,  Joan Eileen Sabalski

    IPC分类号： A61K3155

    CPC分类号： C07D487/06

    摘要： This invention provides [1,4]diazepino[6,7,1-jk]carbazole compounds of the formula: wherein: R1 and R2 are H, alkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, phenoyl or thiophenoyl; R3, R4, R5 and R6 are H, alkyl, cycloalkyl, alkoxy or cycloalkoxy; R7 is H or alkyl; R8 is H or alkyl; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing them for the treatment or prevention of disorders such as obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

    摘要翻译： 本发明提供下式的[1,4]二氮杂[6,7,1-jk]咔唑化合物：其中：R1和R2是H，烷基，烷氧基，卤素，氟化烷基，-CN，-NH-SO2-烷基 ，-SO 2 -NH-烷基，烷基酰胺，氨基，烷基氨基，二烷基氨基，氟化烷氧基，酰基，苯甲酰基或噻吩甲酰基; R3，R4，R5和R6是H，烷基，环烷基，烷氧基或环烷氧基; R7是H或烷基; R8是H或烷基; 虚线表示可选的双键; 或其药学上可接受的盐，以及利用它们用于治疗或预防诸如强迫症，抑郁症，焦虑症，精神分裂症，偏头痛，睡眠障碍，进食障碍，肥胖，癫痫和脊髓障碍的疾病的方法和药物组合物 线损伤。

    Substituted indolizines and derivatives as CNS agents
    5.
    发明授权
    Substituted indolizines and derivatives as CNS agents 失效
    取代的中氮茚衍生物和衍生物作为CNS剂

    公开(公告)号：US07608626B2

    公开(公告)日：2009-10-27

    申请号：US11260716

    申请日：2005-10-27

    申请人： Annmarie Louise Sabb ,  Robert Lewis Vogel

    发明人： Annmarie Louise Sabb ,  Robert Lewis Vogel

    IPC分类号： C07D221/02 ,  A01N43/42 ,  A61K31/44

    CPC分类号： C07D471/04

    摘要： Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

    摘要翻译： 提供式1化合物或其药学上可接受的盐：其是脑5-羟色胺受体2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

    Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
    6.
    发明授权
    Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives 失效
    环戊基[b] [1,4]二氮杂[6,7,1-hi]吲哚及其衍生物

    公开(公告)号：US06777407B2

    公开(公告)日：2004-08-17

    申请号：US10016331

    申请日：2001-11-02

    申请人： Annmarie Louise Sabb ,  Robert Lewis Vogel ,  James Albert Nelson ,  Sharon Joy Rosenzweig-Lipson ,  Gregory Scott Welmaker ,  Joan Eileen Sabalski

    发明人： Annmarie Louise Sabb ,  Robert Lewis Vogel ,  James Albert Nelson ,  Sharon Joy Rosenzweig-Lipson ,  Gregory Scott Welmaker ,  Joan Eileen Sabalski

    IPC分类号： A61K3155

    CPC分类号： C07D209/94 ,  A61K31/55 ,  C07D487/06

    摘要： This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R3 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl, alkoxy of 1-6 carbon atoms, —CH2OH, fluoroalkyl, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, aryl, or aroyl; R4 and R5 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, fluoroalkyl, —CN, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R6 and R7 are each independently hydrogen, C1-C6 alkyl or cycloalkyl; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions containing these compounds and methods for their use, including treatment of obsessive-compulsive disorder, panic disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

    摘要翻译： 本发明提供下式的化合物：其中：R 1是氢，-C（O）CH 3或1-6个碳原子的烷基; R 2和R 3各自独立地是氢，1-6个碳原子的烷基，环烷基，烷氧基 1-6个碳原子的-CH 2 OH，氟代烷基，1-6个碳原子的烷基磺酰胺，1-6个碳原子的烷基酰胺，1-6个碳原子的烷基氨基，每个烷基部分1-6个碳原子的二烷基氨基 ，1-6个碳原子的氟烷氧基，2-7个碳原子的酰基，芳基或芳酰基; R4和R5各自独立地是氢，1-6个碳原子的烷基，1-6个碳原子的烷氧基，卤素， 氟烷基，-CN，1-6个碳原子的烷基磺酰胺，1-6个碳原子的烷基酰胺，1-6个碳原子的烷基氨基，每个烷基部分1-6个碳原子的二烷基氨基，1-6个碳的氟烷氧基 原子，2-7个碳原子的酰基或芳酰基; R6和R7各自独立地为氢，C1-C6烷基或环烷基;或其药学上可接受的盐，以及药物组合物conta 包括治疗强迫症，惊恐障碍，抑郁症，焦虑症，广泛性焦虑症，精神分裂症，偏头痛，睡眠障碍，进食障碍，肥胖，癫痫和脊髓损伤的这些化合物和方法。

    Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
    7.
    发明授权
    Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives 失效
    环辛[b] [1,4]二氮杂[6,7,1-hi]吲哚和衍生物

    公开(公告)号：US06759405B2

    公开(公告)日：2004-07-06

    申请号：US10016228

    申请日：2001-11-02

    申请人： Annmarie Louise Sabb ,  Robert Lewis Vogel

    发明人： Annmarie Louise Sabb ,  Robert Lewis Vogel

    IPC分类号： A61K3155

    CPC分类号： C07D487/06

    摘要： This invention provides compounds of formula I having the structure wherein: R1 and R2 are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated, acyl, or aroyl; R3, R4 are H, alkyl, cycloalkyl or —CH2-cycloalkyl; R5 is H or alkyl; R6 is H or alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods for using these compounds to treat central nervous system disorders, including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

    摘要翻译： 本发明提供具有以下结构的式I化合物，其中R 1和R 2是H，烷基，环烷基，烷氧基，卤素，氟化烷基，-CN，-NH-SO 2 - 烷基，-SO 2 -NH-烷基，烷基酰胺，氨基， 烷基氨基，二烷基氨基，氟化，酰基或芳酰基; R3，R4是H，烷基，环烷基或-CH2-环烷基; R5是H或烷基; R6是H或烷基; 并且其中虚线表示任选的双键; 或其药学上可接受的盐，以及使用这些化合物治疗中枢神经系统疾病（包括强迫症，抑郁症，焦虑症，广泛性焦虑症，精神分裂症，偏头痛，睡眠障碍，进食障碍，肥胖症，癫痫症， 和脊髓损伤。