-
公开(公告)号：US07470799B2
公开(公告)日：2008-12-30
申请号：US11408653
申请日：2006-04-21
IPC分类号： C07D307/00 , A61K31/34
CPC分类号： C07D307/81 , C12P17/04 , C12P17/14
摘要： Compounds of formula I are provided: wherein each of R1, R2, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of melatoninergic receptors. The compounds, and compositions containing the compounds, can be used to treat melatoninergic disorders.
摘要翻译： 提供了式I化合物：其中R 1，R 2，Y，m，n和Ar各自如本文中的类别和亚类所定义和描述，其为褪黑激素受体的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗褪黑激素障碍。
-
公开(公告)号：US07365095B2
公开(公告)日：2008-04-29
申请号：US11409467
申请日：2006-04-21
IPC分类号： A61K31/44 , A61K43/40 , A01N43/02 , A01N43/16 , A61N31/335
CPC分类号： C07D311/04 , C07D311/20 , C07D311/58 , C07D313/08 , C07D401/04 , C07D405/04
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 提供式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， y，m，n和Ar如上所定义，并且在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
-
3.发明授权Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans 失效杂环稠合苯并二恶烷的抗抑郁药氮杂环甲基衍生物公开(公告)号：US07135479B2
公开(公告)日：2006-11-14
申请号：US10659167
申请日：2003-09-10
申请人： Dahui Zhou , Gary Paul Stack
发明人： Dahui Zhou , Gary Paul Stack
IPC分类号： A61K31/44 , A61K31/445 , A61K31/40 , A61K31/405 , A61K31/335 , A61K31/35 , C07D261/20 , C07D411/00 , C07D405/00 , C07D409/00 , C07D205/00 , C07D333/52 , C07D319/14 , C07D307/78
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁症，儿童抑郁症和抑郁症），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为月经前综合征 ），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。
-
公开(公告)号：US07041697B2
公开(公告)日：2006-05-09
申请号：US10659193
申请日：2003-09-10
IPC分类号： A61K31/40 , C07D209/10
CPC分类号： C07D405/12
摘要： Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
-
5.发明授权Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4 失效抑制由VLA-4介导的白细胞粘附的焦谷氨酸衍生物和相关化合物公开(公告)号：US06407066B1
公开(公告)日：2002-06-18
申请号：US09489164
申请日：2000-01-21
申请人： Darren B. Dressen , Anthony Kreft , Dennis Kubrak , Charles William Mann , Michael A. Pleiss , Gary Paul Stack , Eugene D. Thorsett
发明人： Darren B. Dressen , Anthony Kreft , Dennis Kubrak , Charles William Mann , Michael A. Pleiss , Gary Paul Stack , Eugene D. Thorsett
IPC分类号： C07K506
CPC分类号： C07K5/06173 , A61K38/00 , C07K5/06139
摘要： Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
摘要翻译： 披露了结合VLA-4的焦谷氨酸衍生物和相关化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
6.发明授权公开(公告)号：US07479500B2
公开(公告)日：2009-01-20
申请号：US11142787
申请日：2005-06-01
IPC分类号： A61K31/44 , C07D413/14
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁症，儿童抑郁症和抑郁症），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为月经前综合征 ），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。
-
7.发明授权Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans 失效杂环稠合苯并二恶烷的抗抑郁药氮杂环甲基衍生物公开(公告)号：US07419986B2
公开(公告)日：2008-09-02
申请号：US11513700
申请日：2006-08-31
申请人： Dahui Zhou , Gary Paul Stack
发明人： Dahui Zhou , Gary Paul Stack
IPC分类号： A61K31/44 , A61K31/445 , A61K31/40 , A61K31/405 , A61K31/335 , A61K31/35 , C07D261/20 , C07D411/00 , C07D405/00 , C07D409/00 , C07D205/00 , C07D333/52 , C07D319/14 , C07D307/78
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁障碍，儿童抑郁症和心境恶化），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为经前期综合征） 注意力缺陷障碍（伴有或不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。
-
公开(公告)号：US07402687B2
公开(公告)日：2008-07-22
申请号：US11409479
申请日：2006-04-21
申请人： Gary Paul Stack , Jianyao Wang , William Demaio , Ronald Jordan , John Chuck Lem Erve , Rasmy Elsayed Talaat , Matthew John Hoffmann
发明人： Gary Paul Stack , Jianyao Wang , William Demaio , Ronald Jordan , John Chuck Lem Erve , Rasmy Elsayed Talaat , Matthew John Hoffmann
IPC分类号： C07D407/12
CPC分类号： C07D407/12 , C07D307/81 , C07D307/85
摘要： Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.
摘要翻译： 本文描述了式I化合物，其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。 或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 4， R 1，R 2，和n如本文所定义。 这些化合物及其组合物可用于治疗各种中枢神经系统疾病如精神分裂症。
-
9.发明授权Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans 失效杂环稠合苯并二恶烷的抗抑郁药氮杂环甲基衍生物公开(公告)号：US07335666B2
公开(公告)日：2008-02-26
申请号：US11513705
申请日：2006-08-31
申请人： Dahui Zhou , Gary Paul Stack
发明人： Dahui Zhou , Gary Paul Stack
IPC分类号： A61K31/44 , A61K31/445 , A61K31/40 , A61K31/405 , A61K31/335 , A61K31/35 , C07D261/20 , C07D411/00 , C07D405/00 , C07D409/00 , C07D205/00 , C07D333/52 , C07D319/14 , C07D307/78
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁症，儿童抑郁症和抑郁症），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为月经前综合征 ），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。
-
10.发明授权公开(公告)号：US06939877B2
公开(公告)日：2005-09-06
申请号：US10659160
申请日：2003-09-10
IPC分类号： C07D491/04 , C07D498/04 , A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁障碍，儿童抑郁症和心境恶化），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为经前期综合征） 注意力缺陷障碍（伴有或不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.035 秒)
