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1.发明授权Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions 失效加强金属介导的丝氨酸蛋白酶抑制剂与钴或锌离子公开(公告)号：US06255091B1
公开(公告)日：2001-07-03
申请号：US08746986
申请日：1996-11-19
申请人： James M. Clark , Kyle Elrod , Thomas E. Jenkins , Bradley A. Katz , William R. Moore , Robert M. Stroud
发明人： James M. Clark , Kyle Elrod , Thomas E. Jenkins , Bradley A. Katz , William R. Moore , Robert M. Stroud
IPC分类号： C12N999
CPC分类号： C07D401/04 , C07D235/18 , C07D235/20 , C07D401/06 , C07D403/06 , C07K14/811 , C12N9/6424 , C12Q1/37 , G01N2333/045 , G01N2333/811 , G01N2333/96433 , G01N2333/976
摘要： A method is presented for determining if the inhibition of metal mediated serine proteases can be potentiated by cobalt or zinc ions.
摘要翻译： 提出了一种用于确定金属介导的丝氨酸蛋白酶的抑制是否可以被钴或锌离子加强的方法。
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公开(公告)号：US5900371A
公开(公告)日：1999-05-04
申请号：US925844
申请日：1997-09-08
CPC分类号： C12N9/6424 , C07K14/811
摘要： Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.
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公开(公告)号：US5693515A
公开(公告)日：1997-12-02
申请号：US430742
申请日：1995-04-28
CPC分类号： C12N9/6424 , C07K14/811
摘要： Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.
摘要翻译： 提供丝氨酸蛋白酶抑制剂，其包含具有P位结合部分和二价阳离子螯合部分的化合物，其在二价阳离子存在下预先制备为二价阳离子配合物或与丝氨酸蛋白酶组合。 当与二价阳离子络合时，这些化合物被证明具有高的抑制活性，可用于与丝氨酸蛋白酶分离和抑制相关的各种过程。
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公开(公告)号：US06355460B1
公开(公告)日：2002-03-12
申请号：US09351869
申请日：1999-07-12
申请人： James M. Clark , Kyle Elrod , Thomas E. Jenkins , Bradley A. Katz , William R. Moore , Robert M. Stroud
发明人： James M. Clark , Kyle Elrod , Thomas E. Jenkins , Bradley A. Katz , William R. Moore , Robert M. Stroud
IPC分类号： C12N999
CPC分类号： C07D401/04 , C07D235/18 , C07D235/20 , C07D401/06 , C07D403/06 , C07K14/811 , C12N9/6424 , C12Q1/37 , G01N2333/045 , G01N2333/811 , G01N2333/96433 , G01N2333/976
摘要： The present invention relates to serine protease inhibitors having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s) and methods for identifying and using the inhibitors. The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and are useful in various processes associated with serine protease isolation and inhibition.
摘要翻译： 本发明涉及具有P位结合部分和二价阳离子螯合部分的丝氨酸蛋白酶抑制剂，其在二价阳离子存在下预先制备为二价阳离子配合物或与丝氨酸蛋白酶组合， 以及用于鉴定和使用抑制剂的方法。 所述化合物与二价阳离子络合时显示出高的抑制活性，并且可用于与丝氨酸蛋白酶分离和抑制相关的各种过程。
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公开(公告)号：US5925553A
公开(公告)日：1999-07-20
申请号：US925843
申请日：1997-09-08
CPC分类号： C12N9/6424 , C07K14/811
摘要： Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.
摘要翻译： 提供丝氨酸蛋白酶抑制剂，其包含具有P位结合部分和二价阳离子螯合部分的化合物，其在二价阳离子存在下预先制备为二价阳离子配合物或与丝氨酸蛋白酶组合。 当与二价阳离子络合时，这些化合物被证明具有高的抑制活性，可用于与丝氨酸蛋白酶分离和抑制相关的各种过程。
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