公开(公告)号：US20120103075A1

公开(公告)日：2012-05-03

申请号：US13146683

申请日：2010-02-17

申请人： Sylvain Cormier ,  Richard W. Andrews ,  Robert Tacconi ,  Craig H. Dobbs

发明人： Sylvain Cormier ,  Richard W. Andrews ,  Robert Tacconi ,  Craig H. Dobbs

IPC分类号： G01N30/20

CPC分类号： F04B13/02 ,  F04B23/06 ,  G01N1/38 ,  G01N1/40 ,  G01N30/20

摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.

摘要翻译： 描述了用于在液相色谱系统中稀释样品的方法和系统。 将以第一流速流动的样品与以第二流量流动的稀释剂组合预定时间以产生一定体积的稀释样品。 稀释样品根据两种流速测定稀释倍数。 将体积的一部分装载到注射阀的样品环中，随后注入流动到色谱柱的流动相中。 该方法不需要技术人员可以进行稀释或将样品转移到远程位置进行稀释。 有利地，不需要制造或处理进行稀释的停机时间，并且减少流向废物的样品量。

公开(公告)号：US09551329B2

公开(公告)日：2017-01-24

申请号：US13146683

申请日：2010-02-17

申请人： Sylvain Cormier ,  Richard W. Andrews ,  Robert Tacconi ,  Craig H. Dobbs

发明人： Sylvain Cormier ,  Richard W. Andrews ,  Robert Tacconi ,  Craig H. Dobbs

IPC分类号： F04B13/02 ,  G01N1/38 ,  G01N1/40 ,  G01N30/20

CPC分类号： F04B13/02 ,  F04B23/06 ,  G01N1/38 ,  G01N1/40 ,  G01N30/20

摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.

摘要翻译： 描述了用于在液相色谱系统中稀释样品的方法和系统。 将以第一流速流动的样品与以第二流量流动的稀释剂组合预定时间以产生一定体积的稀释样品。 稀释样品根据两种流速测定稀释倍数。 将体积的一部分装载到注射阀的样品环中，随后注入流动到色谱柱的流动相中。 该方法不需要技术人员可以进行稀释或将样品转移到远程位置进行稀释。 有利地，不需要制造或处理进行稀释的停机时间，并且减少流向废物的样品量。

公开(公告)号：US20050147508A1

公开(公告)日：2005-07-07

申请号：US10645082

申请日：2003-08-21

申请人： Joseph Luongo ,  Steven Ciavarinni ,  Robert Tacconi ,  Frank Rubino ,  Robert Dumas

发明人： Joseph Luongo ,  Steven Ciavarinni ,  Robert Tacconi ,  Frank Rubino ,  Robert Dumas

IPC分类号： F04B17/00 ,  F04B35/04 ,  F04B51/00

CPC分类号： F04B51/00 ,  F04B2205/04 ,  F04B2205/05

摘要： Embodiments of the present invention feature a method and apparatus for detecting defects, such as, leaks, component failure and adverse performance. One embodiment of the present apparatus for pumping fluid comprises a pumping chamber having an inlet and an outlet powered by a motor. The motor operates in pumping mode upon receiving a pumping signal. The apparatus further comprises at least one inlet valve in fluid communication with the inlet of the pumping chamber. And, the apparatus comprises a switchable valve in fluid communication with the outlet of the pumping chamber. The switchable valve has a closed position and an open position, and assumes the closed position upon receiving a close signal. A pressure measuring device is in fluid communication with the pumping chamber, between said inlet valve and switchable valve. The pressure measuring device determines a minimal pressure and first threshold pressure at a first time and a second threshold pressure at a second time. The control means calculates the slope of a line representing the difference of said first threshold pressure signal and said second threshold pressure signal over time and comparing the slope with a threshold decay value. And, the control means compares the minimal pressure to a minimal acceptable value. Deviations from such values represent a defect in the pump.

摘要翻译： 本发明的实施例的特征在于用于检测诸如泄漏，部件故障和不利性能之类的缺陷的方法和装置。 用于泵送流体的本装置的一个实施例包括具有由电动机供电的入口和出口的泵送室。 电机在接收到泵送信号时以泵送模式工作。 该装置还包括与泵送室的入口流体连通的至少一个入口阀。 并且，该装置包括与泵送室的出口流体连通的可切换阀。 可切换阀具有关闭位置和打开位置，并且在接收到闭合信号时处于关闭位置。 压力测量装置与所述抽吸室在所述入口阀和可切换阀之间流体连通。 压力测量装置在第一时间确定最小压力和第一阈值压力，并且在第二时间确定第二阈值压力。 控制装置计算表示所述第一阈值压力信号和所述第二阈值压力信号随时间的差的线的斜率，并将该斜率与阈值衰减值进行比较。 而且，控制装置将最小压力与最小可接受值进行比较。 与这些值的偏差代表了泵的缺陷。