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公开(公告)号：US20120103075A1
公开(公告)日：2012-05-03
申请号：US13146683
申请日：2010-02-17
IPC分类号： G01N30/20
摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.
摘要翻译： 描述了用于在液相色谱系统中稀释样品的方法和系统。 将以第一流速流动的样品与以第二流量流动的稀释剂组合预定时间以产生一定体积的稀释样品。 稀释样品根据两种流速测定稀释倍数。 将体积的一部分装载到注射阀的样品环中，随后注入流动到色谱柱的流动相中。 该方法不需要技术人员可以进行稀释或将样品转移到远程位置进行稀释。 有利地，不需要制造或处理进行稀释的停机时间，并且减少流向废物的样品量。
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公开(公告)号：US09551329B2
公开(公告)日：2017-01-24
申请号：US13146683
申请日：2010-02-17
摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.
摘要翻译： 描述了用于在液相色谱系统中稀释样品的方法和系统。 将以第一流速流动的样品与以第二流量流动的稀释剂组合预定时间以产生一定体积的稀释样品。 稀释样品根据两种流速测定稀释倍数。 将体积的一部分装载到注射阀的样品环中，随后注入流动到色谱柱的流动相中。 该方法不需要技术人员可以进行稀释或将样品转移到远程位置进行稀释。 有利地，不需要制造或处理进行稀释的停机时间，并且减少流向废物的样品量。
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公开(公告)号：US20110315633A1
公开(公告)日：2011-12-29
申请号：US13144133
申请日：2010-01-12
申请人： Sylvain Cormier , James P. Murphy
发明人： Sylvain Cormier , James P. Murphy
CPC分类号： F16K11/0655 , F16K11/083
摘要： Described is a rotary valve including a stator element and a rotor element. The stator element defines a first inlet passage, a second inlet passage, and a first outlet passage, respectively, having a first inlet port, second inlet port and first outlet port in a stator face. The rotor element has a rotor face in contact with the stator face and has a first channel and a second channel formed therein. The rotor element is rotatably movable about a rotational axis to at least a first position and a second position. In the first position, the first inlet port is fluidly coupled to the first outlet passage by the first channel and the second inlet port is fluidly coupled to the first outlet passage by the second channel. In the second position, the first inlet port is fluidly coupled to the first outlet passage by the first and second channels.
摘要翻译： 描述了包括定子元件和转子元件的旋转阀。 定子元件分别限定第一入口通道，第二入口通道和第一出口通道，其具有定子面中的第一入口端口，第二入口端口和第一出口端口。 转子元件具有与定子面接触的转子面，并具有形成在其中的第一通道和第二通道。 转子元件可旋转地围绕旋转轴线移动到至少第一位置和第二位置。 在第一位置，第一入口通过第一通道流体耦合到第一出口通道，第二入口通过第二通道流体连接到第一出口通道。 在第二位置，第一入口通过第一和第二通道流体连接到第一出口通道。
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4.发明申请公开(公告)号：US20090039024A1
公开(公告)日：2009-02-12
申请号：US11917562
申请日：2006-06-19
CPC分类号： G01N30/20 , B01D15/1821 , B01D15/1842 , G01N30/22 , G01N30/466 , G01N30/6047 , G01N30/88 , G01N2030/202 , Y10T137/86863 , Y10T436/11
摘要： Embodiments of the present invention feature a device (1) and method for performing steps of a multi-step process in parallel. The device (1) and method feature a rotor assembly (13) having vessel stations (33) and stator assembly (15) having work positions. The rotor assembly (13) rotates the vessels (17) to the work stations to perform steps of a multi-step process at the same time.
摘要翻译： 本发明的实施例具有并行执行多步骤处理步骤的装置（1）和方法。 装置（1）和方法的特征在于具有容器站（33）和具有工作位置的定子组件（15）的转子组件（13）。 转子组件（13）将容器（17）旋转到工作站，以同时执行多步骤的步骤。
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公开(公告)号：US09194504B2
公开(公告)日：2015-11-24
申请号：US13144133
申请日：2010-01-12
申请人： Sylvain Cormier , James P. Murphy
发明人： Sylvain Cormier , James P. Murphy
IPC分类号： F16K11/06 , F16K11/065 , F16K11/083
CPC分类号： F16K11/0655 , F16K11/083
摘要： Described is a rotary valve including a stator element and a rotor element. The stator element defines a first inlet passage, a second inlet passage, and a first outlet passage, respectively, having a first inlet port, second inlet port and first outlet port in a stator face. The rotor element has a rotor face in contact with the stator face and has a first channel and a second channel formed therein. The rotor element is rotatably movable about a rotational axis to at least a first position and a second position. In the first position, the first inlet port is fluidly coupled to the first outlet passage by the first channel and the second inlet port is fluidly coupled to the first outlet passage by the second channel. In the second position, the first inlet port is fluidly coupled to the first outlet passage by the first and second channels.
摘要翻译： 描述了包括定子元件和转子元件的旋转阀。 定子元件分别限定第一入口通道，第二入口通道和第一出口通道，其具有定子面中的第一入口端口，第二入口端口和第一出口端口。 转子元件具有与定子面接触的转子面，并具有形成在其中的第一通道和第二通道。 转子元件可旋转地围绕旋转轴线移动到至少第一位置和第二位置。 在第一位置，第一入口通过第一通道流体耦合到第一出口通道，第二入口通过第二通道流体连接到第一出口通道。 在第二位置，第一入口通过第一和第二通道流体连接到第一出口通道。
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公开(公告)号：US20110020939A1
公开(公告)日：2011-01-27
申请号：US12919565
申请日：2009-02-25
申请人： Sylvain Cormier
发明人： Sylvain Cormier
CPC分类号： G01N30/20 , G01N30/16 , G01N30/38 , G01N35/10 , G01N35/1097 , G01N2001/2893 , G01N2030/042 , G01N2030/201 , G01N2030/202 , G01N2030/207 , G01N2030/385 , Y10T436/10 , Y10T436/2575
摘要： An analytical apparatus includes a sample-injection valve, a sample pump, at least two sources of standards, and a selection valve. The sample-injection valve has an output port in fluid communication with a LC column, and an input port in fluid communication with a mobile-phase supply line. The at least two sources of standards are associated with at least two pharmaceutical compounds. The selection valve fluidically and selectably connects the sample pump to the at least two sources of standards, to the sample-injection valve, and to at least two pharmaceutical-manufacturing process lines associated with the at least two pharmaceutical compounds. A method for controlling a pharmaceutical manufacturing process includes switching the selection valve to alternately and repeatedly sample the at least two sources of standards and material flowing through the at least two pharmaceutical-manufacturing process lines.
摘要翻译： 分析装置包括样品注射阀，样品泵，至少两种标准来源和选择阀。 样品注射阀具有与LC柱流体连通的输出端口和与流动相电源线流体连通的输入端口。 至少两种标准来源与至少两种药物化合物有关。 所述选择阀以流体方式可选择地将所述样品泵连接到所述至少两个标准源，所述样品注射阀以及与所述至少两种药物化合物相关联的至少两个药物制造工艺管线。 用于控制药物制造过程的方法包括切换选择阀以交替地和重复地对流经至少两个药物制造生产线的标准物质和材料进行采样。
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公开(公告)号：US20080309076A1
公开(公告)日：2008-12-18
申请号：US11816295
申请日：2006-02-24
申请人： Sylvain Cormier
发明人： Sylvain Cormier
IPC分类号： F16L17/00
CPC分类号： A61M39/12 , F16L15/001 , F16L15/006 , F16L19/063 , F16L37/02 , F16L37/122 , G01N30/6026
摘要： A device for connecting a fluid conduit to an orifice of a vessel includes a flexible fitting, a deformable fitting, and one or more compression fittings. The flexible fitting can fix a position of the fluid conduit with respect to the orifice of the vessel, and the deformable fitting can provide a fluid seal between the fluid conduit and the orifice of the vessel. A method for connecting a fluid conduit to an orifice of a vessel includes urging a deformable fitting against both a surface of the fluid conduit and the orifice, urging a flexible fitting toward a surface of the fluid conduit, and attaching the flexible fitting to the orifice.
摘要翻译： 用于将流体导管连接到容器的孔口的装置包括柔性配件，可变形配件和一个或多个压缩配件。 柔性配件可以相对于容器的孔口固定流体导管的位置，并且可变形的配件可以在流体导管和容器的孔口之间提供流体密封。 用于将流体导管连接到容器的孔口的方法包括将可变形配件推压到流体导管和孔口的表面上，将柔性配件推向流体导管的表面，以及将柔性配件附接到孔口 。
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8.发明申请公开(公告)号：US20060113794A1
公开(公告)日：2006-06-01
申请号：US11072485
申请日：2005-03-04
申请人： Kenneth Plant , Sylvain Cormier , Geoff Gerhardt
发明人： Kenneth Plant , Sylvain Cormier , Geoff Gerhardt
IPC分类号： F16L19/06
CPC分类号： G01N30/6004 , G01N30/6034
摘要： The present invention is a capillary interconnection fitting and method of clamping a capillary in the fitting that separates a forward ferrule that holds the capillary from a secondary clamping device. The fitting comprises a sealing ferrule, a compression screw and a clamping device. The ferrule is fitted in a compression screw that mates to a fluidic component. The clamping device is decoupled from the ferrule and coupled to the compression screw.
摘要翻译： 本发明是一种毛细管互连配件和夹紧毛细管的方法，该毛细管将管状毛细管的前套管与二次夹紧装置分开。 配件包括密封套圈，压缩螺钉和夹紧装置。 套圈安装在与流体组件配合的压缩螺钉中。 夹紧装置与套圈脱钩并联接到压紧螺钉。
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公开(公告)号：US11112390B2
公开(公告)日：2021-09-07
申请号：US13519798
申请日：2011-02-10
申请人： Sylvain Cormier
发明人： Sylvain Cormier
摘要： An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee.
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10.发明授权公开(公告)号：US08802035B2
公开(公告)日：2014-08-12
申请号：US11917562
申请日：2006-06-19
CPC分类号： G01N30/20 , B01D15/1821 , B01D15/1842 , G01N30/22 , G01N30/466 , G01N30/6047 , G01N30/88 , G01N2030/202 , Y10T137/86863 , Y10T436/11
摘要： Embodiments of the present invention feature a device (1) and method for performing steps of a multi-step process in parallel. The device (1) and method feature a rotor assembly (13) having vessel stations (33) and stator assembly (15) having work positions. The rotor assembly (13) rotates the vessels (17) to the work stations to perform steps of a multi-step process at the same time.
摘要翻译： 本发明的实施例具有并行执行多步骤处理步骤的装置（1）和方法。 装置（1）和方法的特征在于具有容器站（33）和具有工作位置的定子组件（15）的转子组件（13）。 转子组件（13）将容器（17）旋转到工作站，以同时执行多步骤的步骤。
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